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Scientific Articles

Mapping and enumerating houses and households to support malaria control interventions on Bioko Island

August 27, 2019 - 21:57 -- Open Access
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Author(s): 
Guillermo A. García, Dianna E. B. Hergott, Carlos A. Guerra, et al.
Reference: 
Malaria Journal 2019 18:283, 22 August 2019

Housing mapping and household enumeration are essential for the planning, implementation, targeting, and monitoring of malaria control interventions. In many malaria endemic countries, control efforts are hindered by incomplete or non-existent housing cartography and household enumeration. This paper describes the development of a comprehensive mapping and enumeration system to support the Bioko Island Malaria Control Project (BIMCP).

Using a miniaturized double-net trap (DN-Mini) to assess relationships between indoor–outdoor biting preferences and physiological ages of two malaria vectors, Anopheles arabiensis and Anopheles funestus

August 27, 2019 - 21:56 -- Open Access
Author(s): 
Alex J. Limwagu, Emmanuel W. Kaindoa, Fredros O. Okumu, et al.
Reference: 
Malaria Journal 2019 18:282, 22 August 2019

Effective malaria surveillance requires detailed assessments of mosquitoes biting indoors, where interventions such as insecticide-treated nets work best, and outdoors, where other interventions may be required. Such assessments often involve volunteers exposing their legs to attract mosquitoes [i.e., human landing catches (HLC)], a procedure with significant safety and ethical concerns. Here, an exposure-free, miniaturized, double-net trap (DN-Mini) is used to assess relationships between indoor–outdoor biting preferences of malaria vectors, Anopheles arabiensis and Anopheles funestus, and their physiological ages (approximated by parity and insemination states).

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Mass drug administration can be a valuable addition to the malaria elimination toolbox

August 27, 2019 - 21:50 -- Open Access
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Author(s): 
Thomas P. Eisele
Reference: 
Malaria Journal 2019 18:281, 22 August 2019

The Global Technical Strategy 2016–2030 of the World Health Organization (WHO) has the ambitious goal of malaria being eliminated from at least 35 countries by 2030.

Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)

August 27, 2019 - 21:47 -- Open Access
Author(s): 
Jaishree Raman, Frank M. Kagoro, Aaron Mabuza, Gillian Malatje, Anthony Reid, John Frean and Karen I. Barnes
Reference: 
Malaria Journal 2019 18:280, 22 August 2019

The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy monitoring is essential for ensuring effective treatment policies. In low transmission settings where therapeutic efficacy studies are often not feasible, routine surveillance for molecular markers associated with anti-malarial resistance provides an alternative for the early detection of emerging resistance. Such a longitudinal survey of changes in the prevalence of selected molecular markers of resistance was conducted in the malaria-endemic regions of Mpumalanga Province, South Africa, where malaria elimination at a district-level is being pursued.

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Mass drug administration should be implemented as a tool to accelerate elimination: against

August 27, 2019 - 21:44 -- Open Access
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Author(s): 
Kamini Mendis
Reference: 
Malaria Journal 2019 18:279, 22 August 2019

In most malaria situations, mass drug administration (MDA) will result in a rapid reduction in the incidence and prevalence of malaria in the target population.

Determinants of long-lasting insecticidal net ownership and utilization in malaria transmission regions: evidence from Zimbabwe Demographic and Health Surveys

August 27, 2019 - 21:42 -- Open Access
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Author(s): 
Oscar Tapera
Reference: 
Malaria Journal 2019 18:278, 20 August 2019

Long-lasting insecticidal nets (LLINs) were first introduced in 2010 as a vector control intervention, to complement indoor residual spraying, to reduce malaria transmission in Zimbabwe. The objective of this study was to investigate factors that were associated with LLIN ownership and utilization among households in malaria transmission regions of Zimbabwe.

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Efficacy and safety of dihydroartemisinin–piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial

August 27, 2019 - 21:39 -- Open Access
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Author(s): 
Esperança Sevene, Clifford G. Banda, Victor Mwapasa, et al.
Reference: 
Malaria Journal 2019 18:277, 20 August 2019

HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efficacy and safety has not been evaluated in HIV-infected individuals on ART, among whom drug–drug interactions are expected. Day-42 adequate clinical and parasitological response (ACPR) and incidence of adverse events were assessed in HIV-infected individuals on non-nucleoside reverse transcriptase inhibitor-based ART (efavirenz and nevirapine) with uncomplicated P. falciparum malaria treated with dihydroartemisinin–piperaquine.

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Prevalence of Plasmodium parasites in non-human primates and mosquitoes in areas with different degrees of fragmentation in Colombia

August 19, 2019 - 18:04 -- Open Access
Author(s): 
Silvia Rondón, Cielo León, Andrés Link and Camila González
Reference: 
Malaria Journal 2019 18:276, 19 August 2019

Parasites from the genus Plasmodium, the aetiological agent of malaria in humans, can also infect non-human primates (NHP), increasing the potential risk of zoonotic transmission with its associated global public health concerns. In Colombia, there are no recent studies on Plasmodium spp. infecting free-ranging NHP. Thus, this study aimed to determine the diversity of Plasmodium species circulating in fragmented forests in central Colombia, both in Anopheles mosquitoes and in the four sympatric NHP in the region (Ateles hybridus, Cebus versicolor, Alouatta seniculus and Aotus griseimembra), in order to evaluate the risk of infection to humans associated with the presence of sylvatic hosts and vectors infected with Plasmodium spp.

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Molecular detection of drug resistant malaria in Southern Thailand

August 19, 2019 - 17:40 -- Open Access
Author(s): 
Chaturong Noisang, Christiane Prosser, Wieland Meyer, Waenurama Chemoh, John Ellis, Nongyao Sawangjaroen and Rogan Lee
Reference: 
Malaria Journal 2019 18:275, 15 August 2019

Drug resistance within the major malaria parasites Plasmodium vivax and Plasmodium falciparum threatens malaria control and elimination in Southeast Asia. Plasmodium vivax first-line treatment drug is chloroquine together with primaquine, and the first-line treatment for P. falciparum malaria is artemisinin in combination with a partner drug. Plasmodium vivax and P. falciparum parasites resistant to their respective first-line therapies are now found within Southeast Asia. The resistance perimeters may include high transmission regions of Southern Thailand which are underrepresented in surveillance efforts.

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Bed net care practices and associated factors in western Kenya

August 19, 2019 - 17:33 -- Open Access
Author(s): 
Ellen M. Santos, Jenna E. Coalson, Elizabeth T. Jacobs, Yann C. Klimentidis, Stephen Munga, Maurice Agawo, Elizabeth Anderson, Nancy Stroupe and Kacey C. Ernst
Reference: 
Malaria Journal 2019 18:274, 14 August 2019

Insecticide-treated nets (ITNs) and long-lasting insecticidal nets (LLINs) are effective for malaria prevention and are designed to provide nearly 5 years of mosquito protection. However, many ITNs and LLINs become damaged and ineffective for mosquito bite prevention within 1 to 2 years in field conditions. Non-adherence to recommended bed net care and repair practices may partially explain this shortened net longevity.

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