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Scientific Articles

NOT Open Access | Immunological, haematological, and clinical attributes of rural and urban malaria: a case-control study in Ghana

September 8, 2021 - 16:04 -- NOT Open Access
Author(s): 
Acheampong DO, Adu P, Ampomah P, Duedu KO, Aninagyei E
Reference: 
J Parasit Dis. 2021 Sep;45(3):806-816


To compare clinical presentations, haematological and immunological parameters in urban and rural malaria patients. Clinically suspected malaria patients, resident in either rural or urban communities, were selected from seven health facilities in the Greater Accra region of Ghana. For each suspected malaria patient, parasites were detected microscopically and quantified subsequently. In each study site, an equal number of cases and age-matched controls were selected. In both cases and controls, clinical presentations, nutritional status, haematological, and immunological parameters were profiled.

NOT Open Access | High-throughput virtual screening approach involving pharmacophore mapping, ADME filtering, molecular docking and MM-GBSA to identify new dual target inhibitors of PfDHODH and PfCytbc1 complex to combat drug resistant malaria

September 8, 2021 - 16:01 -- NOT Open Access
Author(s): 
Rawat R, Verma SM
Reference: 
J Biomol Struct Dyn. 2021 Sep;39(14):5148-5159

Emerging cases of drug resistance against Artemisinin combination therapies which are the current and the last line of defense against malaria makes the situation very alarming. Due to the liability of single-target drugs to be more prone to drug resistance, the trend of development of dual or multi-target inhibitors is emerging. Recently, a malaria box molecule, MMV007571 which is a well known new permeability pathways inhibitor was investigated to be also multi-targeting Plasmodium falciparum dihydroorotate dehydrogenase and cytochrome bc1 complex.

NOT Open Access | Evolutionary trilogy of malaria, angiotensin II and hypertension: deeper insights and the way forward

September 8, 2021 - 15:59 -- NOT Open Access
Author(s): 
De A, Tiwari A, Pande V, Sinha A
Reference: 
J Hum Hypertens. 2021 Sep 3


Despite clinical and pathological distinctions between malaria and hypertension, accumulated epidemiological and evolutionary evidence indicate the need of deeper understanding how severe malaria contributes to elevated hypertension risk. Malaria is said to exert strong selection pressure on the host genome, thus selecting certain genetic polymorphisms.

NOT Open Access | Diagnosing the drug resistance signature in Plasmodium falciparum: a review from contemporary methods to novel approaches

September 8, 2021 - 15:58 -- NOT Open Access
Author(s): 
Murmu LK, Sahu AA, Barik TK
Reference: 
J Parasit Dis. 2021 Sep;45(3):869-876


The genome sequence project of the human malaria parasite Plasmodium falciparum reveal variations in the parasite DNA sequence. Most of these variations are single nucleotide polymorphism (SNP). A high frequency of single nucleotide polymorphism (SNP) in the Plasmodium falciparum population is usually a benchmark for anti-malarial resistance which allows parasites to be elusive to the chemotherapeutic agents, vaccine and vector control strategies, resulting in the leading cause of morbidity and mortality globally.

Decreased parasite burden and altered host response in children with sickle cell anemia and severe anemia with malaria

September 8, 2021 - 15:56 -- Open Access
Author(s): 
Henrici RC, Sautter CL, Bond C, Opoka RO, Namazzi R, Datta D, Ware RE, Conroy AL, John CC
Reference: 
Blood Adv. 2021 Sep 1:bloodadvances.2021004704

Plasmodium falciparum malaria causes morbidity and mortality in African children with sickle cell anemia (SCA), but comparisons of host responses to P. falciparum between children with SCA (HbSS) and HbAA are limited. We assessed parasite biomass and plasma markers of inflammation and endothelial activation in children with HbAA (n=208) or HbSS (n=22) who presented with severe anemia and P. falciparum parasitemia to Mulago Hospital in Kampala, Uganda. Genotyping was performed at study completion.

NOT Open Access | Preliminary studies on drug delivery of polymeric primaquine microparticles using the liver high uptake effect based on size of particles to improve malaria treatment

September 8, 2021 - 15:54 -- NOT Open Access
Author(s): 
da Silva de Barros AO, Portilho FL, Santos-Oliveira R, et al.
Reference: 
Mater Sci Eng C Mater Biol Appl. 2021 Sep;128:112275

Malaria is the most common parasitic disease around the world, especially in tropical and sub-tropical regions. This parasitic disease can have a rapid and severe evolution. It is transmitted by female anopheline mosquitoes. There is no reliable vaccine or diagnostic test against malaria; instead, Artesunate is used for the treatment of severe malaria and Artemisinin is used for uncomplicated falciparum malaria.

NOT Open Access | Heat-enhancing aggregation of gold nanoparticles combined with loop-mediated isothermal amplification (HAG-LAMP) for Plasmodium falciparum detection

September 8, 2021 - 15:52 -- NOT Open Access
Author(s): 
Suwannin P, Polpanich D, Leelayoova S, Mungthin M, Tangboriboonrat P, Elaissari A, Jangpatarapongsa K, Ruang-Areerate T, Tangchaikeeree T
Reference: 
J Pharm Biomed Anal. 2021 Sep 5;203:114178

Malaria infection represents a major public health and economic issue that leads to morbidity and mortality globally. A highly effective and uncomplicated detection tool is required for malaria control in geographical hotspots of transmission. We developed a simple and more sensitive novel approach for the detection of the 18S rRNA gene of Plasmodium falciparum based on loop-mediated isothermal amplification (LAMP) and visualization using colorimetric, streptavidin-functionalized gold nanoparticles (SA-GNPs).

Monthly biological larviciding associated with a tenfold decrease in larval density in fish farming ponds and reduced community-wide malaria incidence in northwestern Brazil

September 8, 2021 - 15:51 -- Open Access
Author(s): 
Fontoura PS, Silva MF, da Costa AS, Ribeiro FS, Ferreira MS, Ladeia-Andrade S, Tonini J, Rodrigues PT, Castro MC, Ferreira MU
Reference: 
Parasit Vectors. 2021 Sep 3;14(1):445

Larvicides are typically applied to fixed and findable mosquito breeding sites, such as fish farming ponds used in commercial aquaculture, to kill immature forms and thereby reduce the size of adult malaria vector populations. However, there is little evidence suggesting that larviciding may suppress community-wide malaria transmission outside Africa. Here, we tested whether the biological larvicide VectoMax FG applied at monthly intervals to fish farming ponds can reduce malaria incidence in Amazonian Brazil.

Two-Color Duplex Platform for Point-of-Care Differential Detection of Malaria and Typhoid Fever

September 8, 2021 - 15:50 -- Open Access
Author(s): 
Cao XE, Kim J, Mehta S, Erickson D
Reference: 
Anal Chem. 2021 Sep 1

Malaria and typhoid fever are two febrile illnesses prevalent in the tropics that often present overlapping symptoms. In this work, we demonstrate an optical reader-based diagnostics platform for rapid codetection and quantification of two antigen targets: lipopolysaccharide (LPS) for typhoid fever and plasmodium lactate dehydrogenase (pLDH) for malaria infections.

NOT Open Access | In vitro antiplasmodial activity, targeted LC-MS metabolite profiling, and identification of major natural products in the bioactive extracts of Palicourea and Psychotria species from the Amazonia and Atlantic Forest biomes, Brazil

September 7, 2021 - 15:32 -- NOT Open Access
Author(s): 
Gontijo DC, do Nascimento MFA, Rody HVS, Magalhães RA, Margalho LF, Brandão GC, de Oliveira AB
Reference: 
Metabolomics. 2021 Sep 4;17(9):81


To assess the antiplasmodial activity of 24 extracts from Palicourea and Psychotria genera, along with the targeted LC–MS metabolite profiling, as well as identification of the main metabolites in the bioactive extracts.

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