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Scientific Articles

NOT Open Access | Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine

March 24, 2021 - 15:06 -- NOT Open Access
Coonahan ES, Yang KA, Pecic S, De Vos M, Wellems TE, Fay MP, Andersen JF, Tarning J, Long CA
Sci Transl Med. 2021 Mar 17;13(585):eabe1535

Tracking antimalarial drug use and efficacy is essential for monitoring the current spread of antimalarial drug resistance. However, available methods for determining tablet quality and patient drug use are often inaccessible, requiring well-equipped laboratories capable of performing liquid chromatography-mass spectrometry (LC-MS). Here, we report the development of aptamer-based fluorescent sensors for the rapid, specific detection of the antimalarial compounds piperaquine and mefloquine-two slow-clearing partner drugs in current first-line artemisinin-based combination therapies (ACTs).

Mosquito‐repellent controlled‐release formulations for fighting infectious diseases

March 24, 2021 - 14:52 -- Open Access
António B. Mapossa, Walter W. Focke, Robert K. Tewo, René Androsch and Taneshka Kruger
Malaria Journal 2021 20:165, 24 March 2021

Malaria is a principal cause of illness and death in countries where the disease is endemic. Personal protection against mosquitoes using repellents could be a useful method that can reduce and/or prevent transmission of mosquito-borne diseases. The available repellent products, such as creams, roll-ons, and sprays for personal protection against mosquitoes, lack adequate long-term efficacy. In most cases, they need to be re-applied or replaced frequently. The encapsulation and release of the repellents from several matrices has risen as an alternative process for the development of invention of repellent based systems.

Rolling out the radical cure for vivax malaria in Asia: a qualitative study among policy makers and stakeholders

March 24, 2021 - 14:50 -- Open Access
Bipin Adhikari, Ghulam Rhahim Awab and Lorenz von Seidlein
Malaria Journal 2021 20:164, 23 March 2021

Wide-spread implementation of treatment regimens for the radical cure of vivax malaria is hindered by a range of factors. This has resulted in an increase in the relative proportion of vivax malaria and is an important obstacle in the achievement of global malaria elimination by 2030. The main objective of this study was to explore the current policies guiding the treatment plans on vivax malaria, and the factors affecting the implementation of radical cure in South/South East Asian and Asian Pacific countries.

A retail audit of mosquito control products in Busia County, western Kenya

March 24, 2021 - 14:46 -- Open Access
Prisca A. Oria, Vincent Moshi, Julius I. Odero, Sheila Ekodir, April Monroe, Steven A. Harvey, Eric Ochomo and Danielle Piccinini Black
Malaria Journal 2021 20:163, 23 March 2021

Approximately 70% of Kenya’s population is at risk for malaria. The core vector control methods in Kenya are insecticide-treated mosquito nets (ITNs) and indoor residual spraying, with supplementary larval source management. In 2015, 21% of ITNs were accessed through the private retail sector. Despite the private sector role in supplying mosquito control products (MCPs), there is little evidence on the availability, sales trends, and consumer preferences for MCPs other than ITNs. This study, a component of a larger research programme focused on evaluating a spatial repellent intervention class for mosquito-borne disease control, addressed this evidence gap on the role of the private sector in supplying MCPs.

Community acceptance of reactive focal mass drug administration and reactive focal vector control using indoor residual spraying, a mixed‐methods study in Zambezi region, Namibia

March 24, 2021 - 14:44 -- Open Access
Kathryn W. Roberts, Cara Smith Gueye, Michelle S. Hsiang, et al.
Malaria Journal 2021 20:162, 22 March 2021

In Namibia, as in many malaria elimination settings, reactive case detection (RACD), or malaria testing and treatment around index cases, is a standard intervention. Reactive focal mass drug administration (rfMDA), or treatment without testing, and reactive focal vector control (RAVC) in the form of indoor residual spraying, are alternative or adjunctive interventions, but there are limited data regarding their community acceptability.

Anti‐malarial drug effects on parasite dynamics in vivax malaria

March 24, 2021 - 14:41 -- Open Access
Nicholas J. White
Malaria Journal 2021 20:161, 21 March 2021

Relapses of Plasmodium vivax malaria are prevented by 8-aminoquinolines. If hypnozoites survive, then the subsequent blood stage infections in early relapses (< 2 months) are suppressed by the slowly eliminated anti-malarial drugs used to treat the blood stage infection (chloroquine, artemisinin combination treatments), but they are not usually eliminated.

The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China

March 24, 2021 - 14:40 -- Open Access
Herong Huang, Ying Dong, Yanchun Xu, Yan Deng, Canglin Zhang, Shuping Liu, Mengni Chen and Yan Liu
Malaria Journal 2021 20:160, 20 March 2021

Accumulating evidence suggest that compromised CYP2D6 enzyme activity caused by gene mutation could contribute to primaquine failure for the radical cure of vivax malaria. The current study aims to preliminarily reveal the association between the recurrence of vivax malaria in Yunnan Province and CYP2D6 gene mutation by analysing polymorphisms in the entire coding region of human CYP2D6 gene.

Malaria in Eswatini, 2012–2019: a case study of the elimination effort

March 24, 2021 - 14:34 -- Open Access
Theresia Estomih Nkya, Ulrike Fillinger, Makhoselive Dlamini, Onyango P. Sangoro, Rose Marubu, Zulisile Zulu, Emmanuel Chanda, Clifford Maina Mutero and Quinton Dlamini
Malaria Journal 2021 20:159, 20 March 2021

Eswatini was the first country in sub-Saharan Africa to pass a National Malaria Elimination Policy in 2011, and later set a target for elimination by the year 2020. This case study aimed to review the malaria surveillance data of Eswatini collected over 8 years between 2012 and 2019 to evaluate the country’s efforts that targeted malaria elimination by 2020. Coverage of indoor residual spraying (IRS) for vector control and data on malaria cases were provided by the National Malaria Programme (NMP) of Eswatini. The data included all cases treated for malaria in all health facilities.

Research supporting malaria control and elimination in China over four decades: a bibliometric analysis of academic articles published in chinese from 1980 to 2019

March 24, 2021 - 14:31 -- Open Access
Yan-Qiu Du, Guo-Ding Zhu, Jun Cao and Jia-Yan Huang
Malaria Journal 2021 20:158, 20 March 2021

China has accumulated considerable experience in malaria control and elimination over the past decades. Many research papers have been published in Chinese journals. This study intends to describe the development and experience of malaria control and elimination in China by quantitatively analysing relevant research using a bibliometric analysis.


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