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Scientific Articles

In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II

March 13, 2019 - 14:44 -- Open Access
Author(s): 
Kristin E. Poti, Amanda E. Balaban, Priya Pal, Tamaki Kobayashi, Daniel E. Goldberg, Photini Sinnis and David J. Sullivan
Reference: 
Malaria Journal 2019 18:78, 13 March 2019

The data suggest that persistence of PfHRP2 is due to slower clearance of protein from the RBC fraction of the whole blood.

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Exploring the heterogeneity of human exposure to malaria vectors in an urban setting, Bouaké, Côte d’Ivoire, using an immuno-epidemiological biomarker

March 13, 2019 - 14:41 -- Open Access
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Author(s): 
Dipomin F. Traoré, André B. Sagna, Franck Remoue, et al.
Reference: 
Malaria Journal 2019 18:68, 11 March 2019

This study highlights the high risk of malaria exposure in African urban settings and the high heterogeneity of child exposure to the Anopheles vector between neighbourhoods in the same city.

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Defining the ecological and evolutionary drivers of Plasmodium knowlesi transmission within a multi-scale framework

March 13, 2019 - 14:40 -- Open Access
Author(s): 
Gael Davidson, Tock H. Chua, Angus Cook, Peter Speldewinde and Philip Weinstein
Reference: 
Malaria Journal 2019 18:66, 8 March 2019

Plasmodium knowlesi is a zoonotic malaria parasite normally residing in long-tailed and pig-tailed macaques (Macaca fascicularis and Macaca nemestrina, respectively) found throughout Southeast Asia.

Bioassay-guided isolation and identification of gametocytocidal compounds from Artemisia afra (Asteraceae)

March 13, 2019 - 14:38 -- Open Access
Author(s): 
Phanankosi Moyo, Phaladi Kunyane, Mamoalosi A. Selepe, Jacobus N. Eloff, Jandeli Niemand, Abraham I. Louw, Vinesh J. Maharaj and Lyn-Marie Birkholtz
Reference: 
Malaria Journal 2019 18:65, 8 March 2019

This study provides the first instance of isolated compounds from A. afra against P. falciparum gametocytes as a starting point for further investigations on more plant species in search of transmission-blocking compounds.

Human population movement and behavioural patterns in malaria hotspots on the Thai–Myanmar border: implications for malaria elimination

March 12, 2019 - 15:37 -- Open Access
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Author(s): 
Sayambhu Saita, Wirichada Pan-ngum, Suparat Phuanukoonnon, Patchara Sriwichai, Tassanee Silawan, Lisa J. White and Daniel M. Parker
Reference: 
Malaria Journal 2019 18:64, 8 March 2019

An understanding of HPM and concurrent malaria dynamics is important for consideration of targeted public health interventions.

Determinants of bed net use conditional on access in population surveys in Ghana

March 12, 2019 - 15:35 -- Open Access
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Author(s): 
Emily Ricotta, Samuel Oppong, Joshua O. Yukich and Olivier J. T. Briët
Reference: 
Malaria Journal 2019 18:63, 8 March 2019

Net use conditional on access is affected by household characteristics and is also spatially-dependent in Ghana.

UDP-glycosyltransferase genes and their association and mutations associated with pyrethroid resistance in Anopheles sinensis (Diptera: Culicidae)

March 12, 2019 - 15:33 -- Open Access
Author(s): 
Yong Zhou, Wen-Bo Fu, Feng-Ling Si, Zhen-Tian Yan, Yu-Juan Zhang, Qi-Yi He and Bin Chen
Reference: 
Malaria Journal 2019 18:62, 7 March 2019

This study provides the diversity, phylogenetics and evolution of UGT genes, and potential UGT members and mutations involved in pyrethroid resistance in An. sinensis, and lays an important basis for the better understanding and further research on UGT function in defense against insecticide stress.

Investigating the upsurge of malaria prevalence in Zambia between 2010 and 2015: a decomposition of determinants

March 12, 2019 - 15:32 -- Open Access
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Author(s): 
Mukumbuta Nawa, Peter Hangoma, Andrew P. Morse and Charles Michelo
Reference: 
Malaria Journal 2019 18:61, 7 March 2019

The increases in interventions, such as ITNs and IRS, were shown to have contributed to malaria reduction in 2015; however, changes in demographics such as increases in the proportion of more at risk groups among under-five children and rural residents may have overridden the impact of these interventions and resulted in an overall increase.

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K13-propeller gene polymorphisms in Plasmodium falciparum parasite population in malaria affected countries: a systematic review of prevalence and risk factors

March 12, 2019 - 15:31 -- Open Access
Author(s): 
Moses Ocan, Dickens Akena, Sam Nsobya, Moses R. Kamya, Richard Senono, Alison Annet Kinengyere and Ekwaro Obuku
Reference: 
Malaria Journal 2019 18:60, 7 March 2019

This review identified emergence of potential ART-resistance mediating k13 mutations in the African region.

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Evaluation of MAGNet, a long-lasting insecticidal mosquito net against Anopheles fluviatilis in experimental huts in India

March 12, 2019 - 15:26 -- Open Access
Author(s): 
Gunasekaran Kasinathan, Sudhansu Sekhar Sahu, Vijayakumar Tharmalingam, Subramanian Swaminathan, Manju Rahi and Jambulingam Purushothaman
Reference: 
Malaria Journal 2019 18:59, 6 March 2019

MAGNet LN showed extended wash resistance retaining its bio-efficacy up to 25 washes and met the WHOPES requirement of passing Phase II evaluation.

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