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Scientific Articles

Clustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures

January 24, 2020 - 14:47 -- Open Access
Author(s): 
Jeffrey G. Shaffer, Mahamoudou B. Touré, Nafomon Sogoba, Seydou O. Doumbia, Jules F. Gomis, Mouhamadou Ndiaye, Daouda Ndiaye, Ayouba Diarra, Ismaela Abubakar, Abdullahi Ahmad, Muna Affara, Davis Nwakanma, Mary Lukowski, James C. Welty, Frances J. Mather, Joseph Keating & Donald J. Krogstad
Reference: 
Malaria Journal 2020 19:33, 21 January 2020

Because clustering of Plasmodium falciparum infection had been noted previously, the clustering of infection was examined at four field sites in West Africa: Dangassa and Dioro in Mali, Gambissara in The Gambia and Madina Fall in Senegal.

Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

January 24, 2020 - 14:45 -- Open Access
Author(s): 
Cutts JC, Agius PA, Zaw Lin, Powell R, Moore K, Draper B, Simpson JA, Fowkes FJI
Reference: 
BMC Med 18, 14 (2020)

In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women develop protective immunity to pregnancy-associated malaria and this has been hypothesized to be due to the acquisition of antibodies to the parasite variant surface antigen VAR2CSA. In this systematic review we provide the first synthesis of the association between antibodies to pregnancy-specific P. falciparum antigens and pregnancy and birth outcomes.

NOT Open Access | Efficient Transmission of Mixed Plasmodium falciparum/vivax Infections From Humans to Mosquitoes

January 24, 2020 - 14:42 -- NOT Open Access
Author(s): 
Balasubramanian S, Rahman RS, Lon C, Parobek C, Ubalee R, Hathaway N, Kuntawunginn W, My M, Vy D, Saxe J, Lanteri C, Lin FC, Spring M, Meshnick SR, Juliano JJ, Saunders DL, Lin JT
Reference: 
The Journal of Infectious Diseases, Volume 221, Issue 3, 1 February 2020, Pages 428–437

In Southeast Asia, people are often coinfected with different species of malaria (Plasmodium falciparum [Pf] and Plasmodium vivax [Pv]) as well as with multiple clones of the same species. Whether particular species or clones within mixed infections are more readily transmitted to mosquitoes remains unknown.

Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa

January 24, 2020 - 14:40 -- Open Access
Author(s): 
Otieno L, Guerra Mendoza Y, Oneko M, et al.
Reference: 
Vaccine Volume 38, Issue 4, 22 January 2020, Pages 897-906

We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African countries.

Platelet α-granules contribute to organ-specific pathologies in a mouse model of severe malaria

January 22, 2020 - 17:15 -- Open Access
Author(s): 
Darling TK, Schenk MP, Zhou CC, Maloba FM, Mimche PN, Gibbins JM, Jobe SM, Lamb TJ
Reference: 
Blood Advances, Volume 4, Issue 1 January 14 2020

Cerebral malaria and malaria-associated acute lung injury/acute respiratory distress syndrome areamong the most severe complications ofPlasmodiuminfection. While these disease manifestations aremultifactorial, platelets have been described to play a role in the development of both syndromes inhumans1,2and mice.3,4Although the impact of platelets on malaria has been well studied, questionsremain with regard to their contribution to parasite control and immunopathogenesis.

NOT Open Access | Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates

January 20, 2020 - 16:45 -- NOT Open Access
Author(s): 
Sharma B, Kaur S, Legac J, Rosenthal PJ, Kumar V
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 30, Issue 2, 15 January 2020, 126810

A series of 1H-1,2,3-triazole/acylhydrazide-tethered tetrahydro-β-carboline-4-aminoquinoline conjugates was synthesized with an aim to study their anti-plasmodial structure-activity relationship.

NOT Open Access | Type I IFN signalling is required for cationic adjuvant formulation (CAF)01-induced cellular immunity and mucosal priming

January 20, 2020 - 16:42 -- NOT Open Access
Author(s): 
McEntee CP, Moran HBT, Muñoz-Wolf N, Liddicoat AM, Carroll EC, Erbo-Wern J, Coulter IS, Andersen P, Follmann F, Lavelle EC.
Reference: 
Vaccine, Volume 38, Issue 3, 16 January 2020, Pages 635-643

Despite being in the midst of a global pandemic of infections caused by the pathogen Chlamydia trachomatis, a vaccine capable of inducing protective immunity remains elusive. Given the C. trachomatis mucosal port of entry, a formulation compatible with mucosal administration and capable of eliciting potent genital tract immunity is highly desirable. While subunit vaccines are considered safer and better tolerated, these are typically poorly immunogenic and require co-formulation with immune-potentiating adjuvants.

Assessment of climate change impact on the malaria vector Anopheles hyrcanus, West Nile disease, and incidence of melanoma in the Vojvodina Province (Serbia) using data from a regional climate model

January 20, 2020 - 16:38 -- Open Access
Author(s): 
Mihailović DT, Petrić D, Ignjatović-Ćupina A, et al.
Reference: 
PLoS ONE 15(1): e0227679

Motivated by the One Health paradigm, we found the expected changes in temperature and UV radiation (UVR) to be a common trigger for enhancing the risk that viruses, vectors, and diseases pose to human and animal health. We compared data from the mosquito field collections and medical studies with regional climate model projections to examine the impact of climate change on the spreading of one malaria vector, the circulation of West Nile virus (WNV), and the incidence of melanoma.

NOT Open Access | Is the Epidemiology of Plasmodium knowlesi Changing, and What Does This Mean for Malaria Control in Southeast Asia?

January 20, 2020 - 16:31 -- NOT Open Access
Author(s): 
Karunajeewa H, Berman J
Reference: 
Clinical Infectious Diseases, Volume 70, Issue 3, 1 February 2020, Pages 368–369

It has long been clear that the “monkey-malaria” species, Plasmodium knowlesi, is capable of infecting humans. Its name comes from Robert Knowles, the British parasitologist who first demonstrated experimental monkey–human transmission and pioneered its use as “malaria therapy” for syphilis and leprosy from as early as 1932 [1].

NOT Open Access | Desperately Seeking Therapies for Cerebral Malaria

January 20, 2020 - 16:28 -- NOT Open Access
Author(s): 
Riggle BA, Miller LH, Pierce SK
Reference: 
J Immunol January 15, 2020, 204 (2) 327-334

Malaria is a deadly infectious disease caused by parasites of the Plasmodium spp. that takes an estimated 435,000 lives each year, primarily among young African children. For most children, malaria is a febrile illness that resolves with time, but in ∼1% of cases, for reasons we do not understand, malaria becomes severe and life threatening. Cerebral malaria (CM) is the most common form of severe malaria, accounting for the vast majority of childhood deaths from malaria despite highly effective antiparasite chemotherapy.

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