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Scientific Articles

Challenging diagnosis of congenital malaria in non-endemic areas

December 27, 2018 - 15:25 -- Open Access
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Author(s): 
Lorenza Romani, Stefania Pane, Lorenza Putignani, et al.
Reference: 
Malaria Journal 2018 17:470, 14 December 2018

The maternal RDT sample was negative, while the infant RDT was positive; in both cases microscopy of blood smears and PCR showed infection with P. falciparum.

Has doxycycline, in combination with anti-malarial drugs, a role to play in intermittent preventive treatment of Plasmodium falciparum malaria infection in pregnant women in Africa?

December 27, 2018 - 15:22 -- Open Access
Author(s): 
Tiphaine Gaillard, Manon Boxberger, Marylin Madamet and Bruno Pradines
Reference: 
Malaria Journal 2018 17:469, 14 December 2018

According to the World Health Organization (WHO), Plasmodium falciparum malaria during pregnancy is responsible for deleterious consequences for the mother and her child.

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Identification of a PH domain-containing protein which is localized to crystalloid bodies of Plasmodium ookinetes

December 27, 2018 - 15:19 -- Open Access
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Author(s): 
Rachaneeporn Jenwithisuk, Niwat Kangwanrangsan, Tomoko Ishino, et al.
Reference: 
Malaria Journal 2018 17:466, 13 December 2018

CryPH, containing a signal peptide and PH domain, is predominantly expressed in zygotes and ookinetes and is localized to crystalloid bodies in P. yoelii.

Mitochondrial gene sequence variants in children with severe malaria anaemia with or without lactic acidosis: a case control study

December 27, 2018 - 15:15 -- Open Access
Author(s): 
Casey Fowler, Christine Cserti-Gazdewich, Aggrey Dhabangi, Charles Musoke, Himanshu Sharma, Sami S. Amr and Walter Dzik
Reference: 
Malaria Journal 2018 17:467, 13 December 2018

Lactic acidosis in SMA does not appear to be consistently associated with the high prevalence of any mitochondrial gene variant.

Not Open Access | MRI demonstrates glutamine antagonist-mediated reversal of cerebral malaria pathology in mice

December 20, 2018 - 03:27 -- NOT Open Access
Author(s): 
Brittany A. Riggle, Sanhita Sinharay, Dima A. Hammoud, et al.
Reference: 
PNAS December 18, 2018 115 (51) E12024-E12033

The deadliest complication of Plasmodium falciparum infection is cerebral malaria (CM), with a case fatality rate of 15 to 25% in African children despite effective antimalarial chemotherapy.

Medical Treatment: 

The Plasmodium falciparum cytoplasmic translation apparatus: a promising therapeutic target not yet exploited by clinically approved anti-malarials

December 18, 2018 - 16:21 -- Open Access
Author(s): 
Christine Moore Sheridan, Valentina E. Garcia, Vida Ahyong and Joseph L. DeRisi
Reference: 
Malaria Journal 2018 17:465, 12 December 2018

This work exploits a direct and reproducible assay for measuring P. falciparum translation, demonstrating its value in the continued study of protein synthesis in malaria and its inhibition as a drug target.

Not Open Access | Epidemiological aspects of severe child anemia due to malaria in the socio-economic crisis zone at the Bangassou Regional University Hospital in Central Africa: In French

December 13, 2018 - 08:54 -- NOT Open Access
Author(s): 
E. Kalthan, A. Moboy, G. Tekpa, C.M. Pamatika, D.E.R. Nakoune, B. Kofi
Reference: 
Publié dans Médecine d'Afrique Noire 6511 - Novembre 2018 - pages 531-538

One of the major complications of malaria due to Plasmodium falciparum is hemolytic anemia. The generalized military-political crisis of 2013 in the country has led to the dysfunction of the health system, thus promoting the resurgence of cases of diseases including malaria in Bagassou. The objective of this study was to describe the epidemiological aspects of anemia during the malaria of the Child in Bangassou.

NOT Open Access | Cutting Edge: FHR-1 Binding Impairs Factor H–Mediated Complement Evasion by the Malaria Parasite Plasmodium falciparum

December 12, 2018 - 16:29 -- NOT Open Access
Author(s): 
Timo Reiss, Thiago F. de A. Rosa, Katharina Blaesius, Rebecca P. Bobbert, Peter F. Zipfel, Christine Skerka and Gabriele Pradel
Reference: 
The Journal of Immunology Vol. 201, Issue 12, 15 Dec 2018

Human complement is the first line of defense against invading pathogens, including the malaria parasite Plasmodium falciparum.

NOT Open Access | Global Health Journal Club: The Use of Rapid Diagnostic Test (RDT) in the Diagnosis of Congenital Malaria

December 12, 2018 - 16:28 -- NOT Open Access
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Author(s): 
Theodonata Tuyisenge, Michael B Henry, Peter T Cartledge
Reference: 
Journal of Tropical Pediatrics, fmy066

You are working in a neonatal unit in Rwanda, East Africa.

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NOT Open Access | Leukoerythroblastosis in a Young Child with Severe Malaria and Superimposed Gram Negative Infection

December 12, 2018 - 16:25 -- NOT Open Access
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Author(s): 
Rosauro Varo, Antonio Sitoe, Anelsio Cossa, Jaume Ordi, Maria Rozman, Quique Bassat
Reference: 
Journal of Tropical Pediatrics, Volume 64, Issue 6, 1 December 2018, Pages 553–556

Leukoerythroblastosis may be related to different infectious diseases and may also appear in the context of severe malaria.

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