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Scientific Articles

NOT Open Access | Impact of malaria in pregnancy on risk of malaria in young children: systematic review and meta-analyses

March 30, 2020 - 10:19 -- NOT Open Access
Author(s): 
Park S, Nixon CE, Miller O, Choi NK, Kurtis JD, Friedman JF, Michelow IC
Reference: 
J Infect Dis. 2020 Mar 27. pii: jiaa139

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.

Not Open Access | The last British malaria outbreak

March 30, 2020 - 10:17 -- NOT Open Access
Author(s): 
Walker MD
Reference: 
British Journal of General Practice 2020; 70 (693): 182-183

We inevitably associate malaria with tropical climates where the vector Anopheles mosquitoes are abundant. In 2017, there were an estimated 219 million cases worldwide, predominately in sub-Saharan Africa and India, resulting in 435 000 deaths.

In Vitro Activities of MMV Malaria Box Compounds against the Apicomplexan Parasite Neospora caninum, the Causative Agent of Neosporosis in Animals

March 30, 2020 - 10:15 -- Open Access
Author(s): 
Müller J, Winzer PA, Samby K, Hemphill A
Reference: 
Molecules. 2020 Mar 24;25(6). pii: E1460

Neospora caninum is a major cause of abortion in cattle and represents a veterinary health problem of great economic significance. In order to identify novel chemotherapeutic agents for the treatment of neosporosis, the Medicines for Malaria Venture (MMV) Malaria Box, a unique collection of anti-malarial compounds, were screened against N. caninum tachyzoites, and the most efficient compounds were characterized in more detail.

Impact of the first-line treatment shift from dihydroartemisinin/piperaquine to artesunate/mefloquine on Plasmodium vivax drug susceptibility in Cambodia

March 30, 2020 - 10:11 -- Open Access
Author(s): 
Roesch C, Mairet-Khedim M, Kim S, Lek D, Popovici J, Witkowski B
Reference: 
J Antimicrob Chemother. 2020 Mar 24. pii: dkaa092

Cambodia is the epicentre of the emergence of Plasmodium falciparum drug resistance. Much less is known regarding the drug susceptibility of the co-endemic Plasmodium vivax. Only in vitro drug assays can determine the parasite’s intrinsic susceptibility, but these are challenging to implement for P. vivax and rarely performed.

NOT Open Access | The Malaria-High Blood Pressure Hypothesis: Revisited

March 30, 2020 - 10:09 -- NOT Open Access
Author(s): 
Nwokocha CR, Bafor EE, Ajayi OI, Ebeigbe AB
Reference: 
Am J Hypertens. 2020 Mar 24. pii: hpaa051

Malaria etiologies with pathophysiological similarities to hypertension currently constitute a major subject of research. The malaria-high blood pressure hypothesis is strongly supported by observations of the increasing incidence of hypertension in malaria-endemic, low and middle-income countries (LMICs) with poor socio-economic conditions, particularly in sub-Saharan African countries.

NOT Open Access | Influence of selected polymorphisms in disposition genes on lumefantrine pharmacokinetics when coadministered with efavirenz

March 30, 2020 - 10:07 -- NOT Open Access
Author(s): 
Adegbola AJ, Abuitama R, Adeagbo BA, Bolarinwa RA, Olagunju AE, Siccardi M, Owen A, Bolaji OO
Reference: 
Pharmacogenet Genomics. 2020 Mar 23

Coadministration of artemether–lumefantrine and efavirenz has been shown to result in significant interactions. The influence of functional genetic polymorphisms in selected CYPs on the magnitude of this interaction was investigated in pregnant and nonpregnant adults.

Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection

March 30, 2020 - 10:04 -- Open Access
Author(s): 
Rogers KJ, Shtanko O, Vijay R, Mallinger LN, Joyner CJ, Galinski MR, Butler NS, Maury W
Reference: 
Cell Rep. 2020 Mar 24;30(12):4041-4051.e4

During the 2013–2016 Ebola virus (EBOV) epidemic, a significant number of patients admitted to Ebola treatment units were co-infected with Plasmodium falciparum, a predominant agent of malaria. However, there is no consensus on how malaria impacts EBOV infection. The effect of acute Plasmodium infection on EBOV challenge was investigated using mouse-adapted EBOV and a biosafety level 2 (BSL-2) model virus.

Resistance status of Anopheles gambiae (s.l.) to four commonly used insecticides for malaria vector control in South-East Nigeria

March 30, 2020 - 10:02 -- Open Access
Author(s): 
Chukwuekezie O, Nwosu E, Gnanguenon V, et al.
Reference: 
Parasit Vectors. 2020 Mar 24;13(1):152.

Progress made in the control of malaria vectors globally is largely due to the use of insecticides. However, success in the fight against malaria has slowed down or even stalled due to a host of factors including insecticide resistance. The greatest burden of the disease is felt in Africa, particularly Nigeria. Unfortunately, adequate information on insecticide resistance is lacking in many parts of the country, particularly the South-East Zone. Hence, this study aims to bridge the information gap in the Zone.

An assessment of adult mosquito collection techniques for studying species abundance and diversity in Maferinyah, Guinea

March 30, 2020 - 10:00 -- Open Access
Author(s): 
Cansado-Utrilla C, Jeffries CL, Kristan M, Brugman VA, Heard P, Camara G, Sylla M, Beavogui AH, Messenger LA, Irish SR, Walker T
Reference: 
Parasit Vectors. 2020 Mar 24;13(1):150

Several mosquito collection methods are routinely used in vector control programmes. However, they target different behaviours causing bias in estimation of species diversity and abundance. Given the paucity of mosquito trap data in West Africa, we compared the performance of five trap-lure combinations and Human Landing Catches (HLCs) in Guinea.

Blood group and size dependent stability of P. falciparum infected red blood cell aggregates in capillaries

March 25, 2020 - 14:57 -- Open Access
Author(s): 
Jötten AM, Moll K, Wahlgren M, Wixforth A, Westerhausen C
Reference: 
Biomicrofluidics, Volume 14, Issue 2

For Plasmodium falciparum related malaria (B50), one of the outstanding host factors for the development of severe disease is the ABO blood group of malaria patients, where blood group O reduces the probability of severe disease as compared to individuals of groups A, B, or AB.

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