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Scientific Articles

NOT Open Access | Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein

April 23, 2019 - 13:17 -- NOT Open Access
Lenore L. Carias, Sebastien Dechavanne, Christopher L. King, et al.
The Journal of Immunology Vol. 202, Issue 9 1 May 2019

Plasmodium vivax invasion of reticulocytes relies on distinct receptor-ligand interactions between the parasite and host erythrocytes.

Does anthropometric status at 6 months predict the over-dispersion of malaria infections in children aged 6–18 months? A prospective cohort study

April 23, 2019 - 13:16 -- Open Access
Jaden Bendabenda, Noel Patson, Lotta Hallamaa, Ulla Ashorn, Kathryn G. Dewey, Per Ashorn and Kenneth Maleta
Malaria Journal 2019 18:143, 22 April 2019

In children aged 6–18 months living in malaria-endemic settings, LAZ, WAZ, and WLZ do not predict malaria incidence.

Medical Treatment: 

Cytochrome P450 2D6 profiles and their relationship with outcomes of primaquine anti-relapse therapy in Australian Defence Force personnel deployed to Papua New Guinea and East Timor

April 22, 2019 - 12:30 -- Open Access
Nanhua Chen, Simone Dowd, Michelle L. Gatton, Alyson Auliff, Michael D. Edstein and Qin Cheng
Malaria Journal 2019 18:140, 18 April 2019

CYP2D6 phenotype or activity score based on the allele classification was not a major contributor to P. vivax relapse in this ADF cohort.

Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in African children

April 22, 2019 - 12:28 -- Open Access
Monia Guidi, Thomas Mercier, Manel Aouri, Laurent A. Decosterd, Chantal Csajka, Bernhards Ogutu, Gwénaëlle Carn and Jean-René Kiechel
Malaria Journal 2019 18:139, 18 April 2019

The population pharmacokinetic models developed for both AS/DHA and MQ showed a large variability in drug exposure in the investigated African paediatric population.


Hospital-derived antibody profiles of malaria patients in Southwest India

April 22, 2019 - 12:24 -- Open Access
Apoorva Venkatesh, Aarti Jain, Pradipsinh K. Rathod, et al.
Malaria Journal 2019 18:138, 17 April 2019

Seroreactivity at a major hospital in Southwest India reveals antibody responses to P. falciparum and P. vivax in a low malaria transmission region with much migration.

Training through malaria research: building capacity in good clinical and laboratory practice in Liberia

April 22, 2019 - 12:23 -- Open Access
Alfredo Mayor, Guillermo Martínez-Pérez, Núria Casamitjana, et al.
Malaria Journal 2019 18:136, 17 April 2019

This training-through-research programme successfully involved SJCH staff and community members in a practical research exercise on malaria during pregnancy.


Sequence-based identification of Anopheles species in eastern Ethiopia

April 22, 2019 - 12:21 -- Open Access
Tamar E. Carter, Solomon Yared, Shantoy Hansel, Karen Lopez and Daniel Janies
Malaria Journal 2019 18:135, 16 April 2019

The lack of clarity from COI sequence analysis highlights potential challenges of species identification within species complexes.

Medical Condition: 

Potential herd protection against Plasmodium falciparum infections conferred by mass antimalarial drug administrations

April 17, 2019 - 21:06 -- Ingeborg van Schayk
Daniel M Parker, Sai Thein Than Tun, Lisa J White, Ladda Kajeechiwa, May Myo Thwin, Jordi Landier, Victor Chaumeau, Vincent Corbel, Arjen M Dondorp, Lorenz von Seidlein, Nicholas J White, Richard J Maude, François Nosten
eLife 2019;8:e41023

The global malaria burden has decreased over the last decade and many nations are attempting elimination. Asymptomatic malaria infections are not normally diagnosed or treated, posing a major hurdle for elimination efforts. One solution to this problem is mass drug administration (MDA), with success depending on adequate population participation. Here, we present a detailed spatial and temporal analysis of malaria episodes and asymptomatic infections in four villages undergoing MDA in Myanmar.

NOT Open Access | Down‐selecting circumsporozoite protein‐based malaria vaccine: A comparison of malaria sporozoite challenge model

April 16, 2019 - 08:12 -- NOT Open Access
Fitri Amelia, Mitsuhiro Iyori, Talha Bin Emran, Daisuke S. Yamamoto, Kento Genshi, Hiromu Otsuka, Yutaro Onoue, Yenni Yusuf, Ashekul Islam, Shigeto Yoshida
Parasite Immunology Volume41, Issue5 May 2019 e12624

Plasmodium falciparum circumsporozoite protein (PfCSP) is the main target antigen in development of pre‐erythrocytic malaria vaccines.


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