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Scientific Articles

The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis

October 15, 2019 - 15:36 -- Open Access
Author(s): 
Robert J. Commons, Julie A. Simpson, Ric N. Price, et al.
Reference: 
PLoS Med 16(10): e1002928

Artemisinin-based combination therapy (ACT) is recommended for uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We undertook a systematic review and individual patient data meta-analysis to compare the efficacies of dihydroartemisinin-piperaquine (DP) and artemether-lumefantrine (AL) with or without primaquine (PQ) on the risk of recurrent P. vivax.

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Relationship Between Pregnancy-Associated Malaria and Adverse Pregnancy Outcomes: a Systematic Review and Meta-Analysis

October 15, 2019 - 15:27 -- Open Access
Author(s): 
Julie M Thompson, Stephanie M Eick, Cody Dailey, Ariella P Dale, Mansi Mehta, Anjali Nair, Jose F. Cordero and Michael Welton
Reference: 
Journal of Tropical Pediatrics, fmz068

Pregnancy-associated malaria (PAM) has been associated with adverse pregnancy outcomes like preterm birth (PTB) and low birthweight (LBW), which are among the leading causes of infant mortality globally. Rates of PTB and LBW are high in countries with a high burden of malaria. PAM may be a contributing factor to PTB and LBW, but is not well understood.

Not Open Access | Unusual dynamics of the divergent malaria parasite PfAct1 actin filament

October 15, 2019 - 15:24 -- NOT Open Access
Author(s): 
Hailong Lu, Patricia M. Fagnant, and Kathleen M. Trybus
Reference: 
PNAS October 8, 2019 116 (41) 20418-20427

Gliding motility and host cell invasion by the apicomplexan parasite Plasmodium falciparum (Pf), the causative agent of malaria, is powered by a macromolecular complex called the glideosome that lies between the parasite plasma membrane and the inner membrane complex.

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Enhanced uptake, high selective and microtubule disrupting activity of carbohydrate fused pyrano-pyranones derived from natural coumarins attributes to its anti-malarial potential

October 15, 2019 - 15:23 -- Open Access
Author(s): 
Sonal Gupta, Juveria Khan, Priti Kumari, Chintam Narayana, R. Ayana, Malabika Chakrabarti, Ram Sagar and Shailja Singh
Reference: 
Malaria Journal 2019 18:346, 11 October 2019

Malaria is one of the deadliest infectious diseases caused by protozoan parasite of Plasmodium spp. Increasing resistance to anti-malarials has become global threat in control of the disease and demands for novel anti-malarial interventions. Naturally-occurring coumarins, which belong to a class of benzo-α-pyrones, found in higher plants and some essential oils, exhibit therapeutic potential against various diseases. However, their limited uptake and non-specificity has restricted their wide spread use as potential drug candidates.

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Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study

October 14, 2019 - 15:22 -- Open Access
Author(s): 
Robyn E. Elphinstone, Andrea M. Weckman, Kevin C. Kain, et al.
Reference: 
PLoS Med 16(10): e1002914

Malaria in pregnancy is associated with adverse birth outcomes. However, the underlying mechanisms remain poorly understood. Tight regulation of angiogenic, metabolic, and inflammatory pathways are essential for healthy pregnancies. We hypothesized that malaria disrupts these pathways leading to preterm birth (PTB).

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EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

October 14, 2019 - 15:19 -- Open Access
Author(s): 
Paolo Mesén-Ramírez, Bärbel Bergmann, Thuy Tuyen Tran, Matthias Garten, Jan Stäcker, Isabel Naranjo-Prado, Katharina Höhn, Joshua Zimmerberg, Tobias Spielmann
Reference: 
PLoS Biol 17(9): e3000473

Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar membrane (PVM).

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Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study

October 14, 2019 - 15:17 -- Open Access
Author(s): 
Tarekegn Solomon, Eskindir Loha, Wakgari Deressa, Taye Gari, Bernt Lindtjørn
Reference: 
PLoS ONE 14(9): e0222986

Understanding the spatiotemporal clustering of malaria transmission would help target interventions in settings of low malaria transmission. The aim of this study was to assess whether malaria infections were clustered in areas with long-lasting insecticidal nets (LLINs) alone, indoor residual spraying (IRS) alone, or a combination of LLINs and IRS interventions, and to determine the risk factors for the observed malaria clustering in southern-central Ethiopia.

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NOT Open Access | Potential role of arteether on N-methyl-D-aspartate (NMDA) receptor expression in experimental cerebral malaria mice and extension of their survival

October 8, 2019 - 15:38 -- NOT Open Access
Author(s): 
Sunil Kumar Singh, Hemlata Dwivedi, Sarika Gunjan, Bhavana Singh Chauhan, Swaroop Kumar Pandey, Renu Tripathi
Reference: 
Parasitology, Volume 146, Issue 12, October 2019, pp. 1571-1577

Cerebral malaria (CM) is the severe neurological complication causing acute non-traumatic encephalopathy in tropical countries.

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Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

October 8, 2019 - 15:36 -- Open Access
Author(s): 
Frank Lennartz, Cameron Smith, Alister G. Craig, and Matthew K. Higgins
Reference: 
PNAS October 1, 2019 116 (40) 20124-20134

A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals.

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