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Scientific Articles

Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia

November 30, 2019 - 04:44 -- Open Access
Author(s): 
Ahmed MA, Saif A, Quan FS
Reference: 
PLoS One. 2019 Nov 21;14(11):e0224743.

Human infections due to the monkey malaria parasite Plasmodium knowlesi are increasingly being reported from Malaysia. The parasite causes high parasitaemia, severe and fatal malaria in humans thus there is a need for urgent measures for its control.

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Functional genomics of simian malaria parasites and host–parasite interactions

November 28, 2019 - 20:27 -- Open Access
Author(s): 
Mary R Galinski
Reference: 
Briefings in Functional Genomics, Volume 18, Issue 5, September 2019, Pages 270–280

Two simian malaria parasite species, Plasmodium knowlesi and Plasmodium cynomolgi, cause zoonotic infections in Southeast Asia, and they have therefore gained recognition among scientists and public health officials. Notwithstanding, these species and others including Plasmodium coatneyi have served for decades as sources of knowledge on the biology, genetics and evolution of Plasmodium, and the diverse ramifications and outcomes of malaria in their monkey hosts.

Clinical malaria and the potential risk of anaemia among preschool-aged children: a population-based study of the 2015-2016 Malawi micronutrient survey

November 28, 2019 - 06:41 -- Open Access
Author(s): 
Ntenda PAM, Chilumpha S, Mwenyenkulu ET, Kazambwe JF, El-Meidany W.
Reference: 
Infectious Diseases of Poverty volume 8, Article number: 95 (2019)

Anaemia and malaria are common and life-threatening diseases among preschool-aged children in many tropical and subtropical areas, and Malawi is no exception. Accordingly, this study aimed to examine the association of referral clinical malaria with anemia (hemoglobin [Hb] < 110 g/L) in preschool-aged children in Malawi.

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The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs

November 28, 2019 - 06:36 -- Open Access
Author(s): 
El Moussawi L, Nakhleh J, Kamareddine L, Osta MA.
Reference: 
PLoS Pathog 15(11): e1008194

Serine protease cascades regulate important insect immune responses namely melanization and Toll pathway activation. An important component of these cascades are clip-domain serine protease homologs (cSPHs), which are non-catalytic, but essential for activating the enzyme prophenoloxidase (PPO) in the melanization response during septic infections. The activation of cSPHs requires their proteolytic cleavage, yet factors that control their activation and the complexity of their interactions within these cascades remain unclear. Here, we report the identification of CLIPA28 as a novel immune-related cSPH in the malaria vector Anopheles gambiae.

Aspartate aminotransferase-to-platelet ratio index (APRI): A potential marker for diagnosis in patients at risk of severe malaria caused by Plasmodium vivax

November 28, 2019 - 06:35 -- Open Access
Author(s): 
Guedes KS, Sanchez BAM, Gomes LT, Fontes CJF.
Reference: 
PLoS One. 2019 Nov 25;14(11):e0224877

Acute infection with Plasmodium vivax, classically associated with benign disease, has been presenting as serious and even fatal disease in recent years. Severe disease is mainly due to biochemical and hematological alterations during the acute phase of infection. In the present cross-sectional study, the aspartate aminotransferase-to-platelet ratio index (APRI) was evaluated as a method for identifying patients at risk of severe vivax malaria.

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NOT Open Access | Antimalarial herbal remedies of Bukavu and Uvira areas in DR Congo: An ethnobotanical survey

November 28, 2019 - 06:32 -- NOT Open Access
Author(s): 
Mboni Henry Manya, Flore Keymeulen, Jérémie Ngezahayoc, Amuri Salvius Bakaria, Mutombo Emery Kalonda, Byanga Joh Kahumba, Pierre Duez, Caroline Stévigny, Simbi Jean-Baptiste Lumbu
Reference: 
Journal of Ethnopharmacology, 22 November 2019, 112422

The main objective of the present study was to collect and gather information on herbal remedies traditionally used for the treatment of malaria in Bukavu and Uvira, two towns of the South Kivu province in DRC.

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Anopheles cinereus implicated as a vector of malaria transmission in the highlands of north-west Ethiopia

November 28, 2019 - 06:29 -- Open Access
Author(s): 
Lemma W, Alemu K, Birhanie M, Worku L, Niedbalski J, McDowell MA, Lobo NF.
Reference: 
Parasites & Vectors volume 12, Article number: 557 (2019)

Transmission of malaria in the highlands of Ethiopia is poorly understood and usually attributed to importation by mobile populations or local transmission by Anopheles arabiensis. To characterize and identify Anopheles species present in a highland area of northern Ethiopia, adult and larval collections were performed in Gondar town and the neighboring Senbet Debir village (Dembia district, > 2000 meters above sea level, masl), in addition to Bahir Dar town (capital of Amhara region) and Kumer Aftit village (Metema district, < 2000 masl).

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Evaluation of the operational capacity of first-line health facilities in the management of malaria in Ivory Coast

November 27, 2019 - 16:29 -- Open Access
Author(s): 
Meless D, Hounsa A, Sangaré A, Pongathié A, Kouakou J, Samba M, Kouadio L.
Reference: 
Pan Afr Med J. 2019 Sep 6;34:16.

Do health facilities (HF) have basic resources needed to manage malaria? The purpose of our study was to analyze the operational capacity (OC) of first-line health facilities in Ivory Coast in the management of malaria.

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NOT Open Access | Regulated rutin co-administration reverses mitochondrial-mediated apoptosis in Plasmodium berghei-infected mice

November 27, 2019 - 16:21 -- NOT Open Access
Author(s): 
Oludele OJ, Adisa BA, Olufunso OO.
Reference: 
Biochem Biophys Res Commun. 2019 Nov 22. pii: S0006-291X(19)32187-4.

Malarial infection causes apoptosis in hepatocytes. However, it is not known if co-administration of antimalarial drug with rutin will reverse the apoptotic effects of malarial infection. Plasmodium berghei-infected mice were assigned into groups as follows: groups I to III were treated with the vehicle (Parasitised Untreated, PU), 10 mg/kg body weight of Artesunate-Mefloquine (AM) and Dihydroartemisinin-Piperaquine (DP) respectively.

Ultrasensitive and label-free biosensor for the detection of Plasmodium falciparum histidine-rich protein II in saliva

November 27, 2019 - 16:18 -- Open Access
Author(s): 
Soraya GV, Abeyrathne CD, Buffet C, Huynh DH, Uddin SM, Chan J, Skafidas E, Kwan P, Rogerson SJ
Reference: 
Sci Rep. 2019 Nov 25;9(1):17495

Malaria elimination is a global public health priority. To fulfil the demands of elimination diagnostics, we have developed an interdigitated electrode sensor platform targeting the Plasmodium falciparum Histidine Rich Protein 2 (PfHRP2) protein in saliva samples. A protocol for frequency-specific PfHRP2 detection in phosphate buffered saline was developed, yielding a sensitivity of 2.5 pg/mL based on change in impedance magnitude of the sensor.

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