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Scientific Articles

NOT Open Access | Viability Screen of LOPAC1280 Reveals Tyrosine Kinase Inhibitor Tyrphostin A9 as a Novel Partner Drug for Artesunate Combinations To Target the Plasmodium falciparum Ring Stage

April 2, 2019 - 11:46 -- NOT Open Access
Author(s): 
Jie Xin Tong, Sarah E. L. Ang, Esther H. N. Tan and Kevin S. W. Tan
Reference: 
Antimicrob Agents Chemother 63:e02389-18

The emergence of artemisinin-resistant Plasmodium falciparum poses a major threat to current frontline artemisinin combination therapies.

NOT Open Access | Dysregulation of solute carrier transporters in malaria‐infected pregnant mice

April 2, 2019 - 11:36 -- NOT Open Access
Author(s): 
Najwa Najjar, Eliza R. McColl, Andrea Weckman, Kevin C. Kain, Micheline Piquette‐Miller
Reference: 
Parasite Immunology, Volume41, Issue4 April 2019 e12614

Malaria in pregnancy significantly alters the expression of SLC transporters in maternal and foetal tissues as well as the placenta, regardless of L‐arginine supplementation.

The prevalence and antifolate drug resistance profiles of Plasmodium falciparum in study participants randomized to discontinue or continue cotrimoxazole prophylaxis

April 2, 2019 - 11:18 -- Open Access
Author(s): 
Dennis W. Juma, Peninah Muiruri, Krista Yuhas, Grace John-Stewart, Ronald Ottichilo, John Waitumbi, Benson Singa, Christina Polyak, Edwin Kamau
Reference: 
PLoS Negl Trop Dis 13(3): e0007223

The frequencies of mutations in pfdhfr and pfdhps genes were higher in STOP-CTX arm compared to CTX arm, suggesting cotrimoxazole effectively controls and selects against SP-resistant parasites.

Changing epidemiology and challenges of malaria in China towards elimination

April 2, 2019 - 11:15 -- Open Access
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Author(s): 
Shengjie Lai, Junling Sun, Nick W. Ruktanonchai, Sheng Zhou, Jianxing Yu, Isobel Routledge, Liping Wang, Yaming Zheng, Andrew J. Tatem and Zhongjie Li
Reference: 
Malaria Journal 2019 18:107, 29 March 2019

China is on the verge of malaria elimination, but the residual transmission in border regions and the threats of importation from Africa and Southeast Asia are the key challenges to achieve and maintain malaria elimination.

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Molecular epidemiology of residual Plasmodium vivax transmission in a paediatric cohort in Solomon Islands

March 28, 2019 - 16:34 -- Open Access
Author(s): 
Yi Wan Quah, Andreea Waltmann, Ivo Mueller, et al.
Reference: 
Malaria Journal 2019 18:106, 28 March 2019

Residual malaria transmission in Ngella exhibits strong heterogeneity and is characterized by a high proportion of submicroscopic and asymptomatic P. vivax infections, alongside sporadic P. falciparum infections.

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Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study

March 28, 2019 - 16:32 -- Open Access
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Author(s): 
Michael Nambozi, Halidou Tinto, Umberto D’Alessandro, et al.
Reference: 
Malaria Journal 2019 18:105, 28 March 2019

Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby.

Accuracy of malaria diagnosis by clinical laboratories in Belgium

March 28, 2019 - 16:30 -- Open Access
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Author(s): 
Laura Loomans, Anali Conesa Botella, Agnes D’hondt, Jacob Verschueren, Dorien Van den Bossche, Marjan Van Esbroeck and Jan Jacobs
Reference: 
Malaria Journal 2019 18:104, 28 March 2019

Diagnostic laboratories in a malaria non-endemic setting provided excellent diagnosis of malaria and P. falciparum, reasonably good diagnosis of non-falciparum infections and acceptable calculation of P. falciparum parasite density.

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Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east Senegal: A cluster-randomised trial

March 28, 2019 - 16:07 -- Open Access
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Author(s): 
Jean Louis A. Ndiaye, Youssoupha Ndiaye, Paul Milligan, et al.
Reference: 
PLoS Med 16(3): e1002762

 

In this study SMC for children under 10 years of age given over 5 months was feasible, well tolerated, and effective in preventing malaria episodes, and reduced the prevalence of parasitaemia and anaemia. SMC with CCM achieved high coverage and ensured children with malaria were promptly treated with artemether-lumefantrine.

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NOT Open Access | The drivers and consequences of unstable Plasmodium dynamics: a long-term study of three malaria parasite species infecting a tropical lizard

March 28, 2019 - 16:04 -- NOT Open Access
Author(s): 
Luisa Otero, Jos J. Schall, Virnaliz Cruz, Kristen Aaltonen, Miguel A. Acevedo
Reference: 
Parasitology, Volume 146 / Issue 4, April 2019, pp 453 - 461

Understanding the consequences of environmental fluctuations for parasite dynamics requires a long-term view stretching over many transmission cycles.

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt"

March 28, 2019 - 15:58 -- Open Access
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Author(s): 
Mateus H. Gouveia, Andrew W. Bergen, Sam M. Mbulaiteye, et al.
Reference: 
PLoS Genet 15(3): e1008027

Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria.

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