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Scientific Articles

Evaluation of automated malaria diagnosis using the Sysmex XN-30 analyser in a clinical setting

January 22, 2019 - 15:12 -- Open Access
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Author(s): 
Evashin Pillay, Shanaz Khodaiji, Belinda C. Bezuidenhout, Monwabisi Litshie and Thérèsa L. Coetzer
Reference: 
Malaria Journal 2019 18:15, 22 January 2019

The novel technology of the Sysmex XN-30 provides a robust, rapid, automated and accurate platform for diagnosing malaria in a clinical setting.

Evaluation of Plasmodium vivax malaria recurrence in Brazil

January 22, 2019 - 15:09 -- Open Access
Author(s): 
André Daher, Júlio C. A. L. Silva, Antony Stevens, Paola Marchesini, C. J. Fontes, F. O. Ter Kuile and David G. Lalloo
Reference: 
Malaria Journal 2019 18:18, 22 January 2019

Short course primaquine was as effective as 14-day regimens and associated with a halving of the risk and delay in time to recurrence of P. vivax infections in comparison to chloroquine alone.

Medical Treatment: 

Comparative analysis of IgG and IgG subclasses against Plasmodium falciparum MSP-119 in children from five contrasting bioecological zones of Cameroon

January 22, 2019 - 15:07 -- Open Access
Author(s): 
Tebit Emmanuel Kwenti, Tufon Anthony Kukwah, Theresa Nkuo-Akenji, et al.
Reference: 
Malaria Journal 2019 18:16, 22 January 2019

This study showed that antibody responses against MSP-119 vary considerably in children from the different bioecological strata in Cameroon and could be linked to the differential exposure to malaria in the different strata.

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Risk of transfusion-transmitted malaria: evaluation of commercial ELISA kits for the detection of anti-Plasmodium antibodies in candidate blood donors

January 22, 2019 - 15:06 -- Open Access
Author(s): 
Valentina D. Mangano, Francesca Perandin, Fabrizio Bruschi, et al.
Reference: 
Malaria Journal 2019 18:17, 22 January 2019

These preliminary results indicate how the lack of a gold standard for malaria serology must be taken into account in the application and future revision of current legislation.

Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria

January 22, 2019 - 14:59 -- Open Access
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Author(s): 
Lynn Grignard, Catherine Mair, Chris Drakeley, et al.
Reference: 
Malaria Journal 2019 18:14, 21 January 2019

The bead based assay compares well to alternative measures of genotyping and phenotyping for G6PD.

An online mapping database of molecular markers of drug resistance in Plasmodium falciparum: the ACT Partner Drug Molecular Surveyor

January 22, 2019 - 14:56 -- Open Access
Author(s): 
Sabina Dahlström Otienoburu, Ignacio Suay, Steven Garcia, Nigel V. Thomas, Suttipat Srisutham, Anders Björkman and Georgina S. Humphreys
Reference: 
Malaria Journal 2019 18:12, 18 January 2019

The WWARN ACT Partner Drugs Molecular Surveyor summarizes data on resistance markers in the pfmdr1 and pfcrt genes.

Immunoglobulin G subclass and antibody avidity responses in Malian children immunized with Plasmodium falciparum apical membrane antigen 1 vaccine candidate FMP2.1/AS02A

January 22, 2019 - 14:54 -- Open Access
Author(s): 
Andrea A. Berry, Eric R. Gottlieb, Kirsten E. Lyke, et al.
Reference: 
Malaria Journal 2019 18:13, 18 January 2019

AMA1 vaccination did not elicit a change in antibody avidity; however, AMA1 vaccinees had a robust IgG subclass response that persisted over the malaria transmission season.

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The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children

January 22, 2019 - 14:51 -- Open Access
Author(s): 
Priyanka Barua, James G. Beeson, Kenneth Maleta, Per Ashorn and Stephen J. Rogerson
Reference: 
Malaria Journal 2019 18:11, 18 January 2019

Antibodies to merozoite and IE surface antigens increased following infection in early childhood, but neither age at first infection nor number of malaria episodes substantially affected antibody acquisition.

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Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central Vietnam

January 22, 2019 - 14:49 -- Open Access
Author(s): 
Nguyen Chinh Phong, Marina Chavchich, Huynh Hong Quang, Nguyen Ngoc San, Geoffrey W. Birrell, Ilin Chuang, Nicholas J. Martin, Nguyen Duc Manh and Michael D. Edstein
Reference: 
Malaria Journal 2019 18:10, 17 January 2019

Clinical findings, molecular analysis and in vitro testing revealed that the falciparum parasites at Phuoc Chien Commune were artemisinin susceptible.

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Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d’Ivoire

January 15, 2019 - 15:32 -- Open Access
Author(s): 
Eveline Hürlimann, Clarisse A. Houngbedji, Richard B. Yapi, Prisca B. N’Dri, Kigbafori D. Silué, Mamadou Ouattara, Jürg Utzinger, Eliézer K. N’Goran, Giovanna Raso
Reference: 
PLoS Negl Trop Dis 13(1): e0007086

No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5–18 years nor in adults from the community-based studies.

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