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Scientific Articles

Evaluation of Plasmodium falciparum MSP10 and its development as a serological tool for the Peruvian Amazon region

September 30, 2019 - 13:28 -- Open Access
Author(s): 
Jorge Bendezu, Elizabeth Villasis, Katherine Torres, et al.
Reference: 
Malaria Journal 2019 18:327, 23 September 2019

Different antigens are needed to characterize Plasmodium falciparum infection in terms of seroreactivity and targets for invasion inhibition, in order to guide and identify the proper use of such proteins as tools for the development of serological markers and/or as vaccine candidates.

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Not Open Access | Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China

September 30, 2019 - 13:26 -- NOT Open Access
Author(s): 
Ruimin Zhou, Chengyun Yang, Suhua Li, Yuling Zhao, Ying Liu, Dan Qian, Hao Wang, Deling Lu, Hongwei Zhang and Fang Huang
Reference: 
Antimicrob. Agents Chemother. September 2019 63:e00552-19

Angola was the main origin country for the imported malaria in Henan Province, China.

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The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion

September 24, 2019 - 15:15 -- Open Access
Author(s): 
Emma S. Sherling, Abigail J. Perrin, Ellen Knuepfer, Matthew R. G. Russell, Lucy M. Collinson, Louis H. Miller, Michael J. Blackman
Reference: 
PLoS Pathog 15(9): e1008049

The malaria parasite Plasmodium falciparum invades, replicates within and destroys red blood cells in an asexual blood stage life cycle that is responsible for clinical disease and crucial for parasite propagation.

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Frequent expansion of Plasmodium vivax Duffy Binding Protein in Ethiopia and its epidemiological significance

September 24, 2019 - 15:08 -- Open Access
Author(s): 
Eugenia Lo, Jessica B. Hostetler, Guiyun Yan, et al.
Reference: 
PLoS Negl Trop Dis 13(9): e0007222

Plasmodium vivax invasion of human erythrocytes depends on the Duffy Binding Protein (PvDBP) which interacts with the Duffy antigen.

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Predicting gene expression in the human malaria parasite Plasmodium falciparum using histone modification, nucleosome positioning, and 3D localization features

September 24, 2019 - 15:06 -- Open Access
Author(s): 
David F. Read, Kate Cook, Yang Y. Lu, Karine G. Le Roch, William Stafford Noble
Reference: 
PLoS Comput Biol 15(9): e1007329

Empirical evidence suggests that the malaria parasite Plasmodium falciparum employs a broad range of mechanisms to regulate gene transcription throughout the organism’s complex life cycle.

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Differential expression of var subgroups and PfSir2a genes in afebrile Plasmodium falciparum malaria: a matched case–control study

September 24, 2019 - 15:04 -- Open Access
Author(s): 
Himanshu Gupta, Beatriz Galatas, Alfredo Mayor, et al.
Reference: 
Malaria Journal 2019 18:326, 23 September 2019

Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multiplication and gametocyte maturation with afebrile malaria was assessed.

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Pharmacokinetics/pharmacodynamics of chloroquine and artemisinin-based combination therapy with primaquine

September 24, 2019 - 14:59 -- Open Access
Author(s): 
André Daher, Ghait Aljayyoussi, David G. Lalloo, et al.
Reference: 
Malaria Journal 2019 18:325, 23 September 2019

Activation of hypnozoites of vivax malaria causes multiple clinical relapses, which contribute to the Plasmodium vivax burden and continuing transmission. Artemisinin-based combination therapy (ACT) is effective against blood-stage P. vivax but requires co-administration with primaquine to achieve radical cure. The therapeutic efficacy of primaquine depends on the generation of a therapeutically active metabolite via cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 metabolism has been associated with primaquine treatment failure. This study investigated the association between impaired CYP2D6 genotypes, drug-exposure to the long-acting ACT component (schizonticidal drugs) and tolerance and efficacy.

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Targeted Next Generation Sequencing for malaria research in Africa: current status and outlook

September 24, 2019 - 14:56 -- Open Access
Author(s): 
Anita Ghansah, Edwin Kamau, Abdoulaye Djimde, et al.
Reference: 
Malaria Journal 2019 18:324, 23 September 2019

Targeted Next Generation Sequencing (TNGS) is an efficient and economical Next Generation Sequencing (NGS) platform and the preferred choice when specific genomic regions are of interest.

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“Remarkable solutions to impossible problems”: lessons for malaria from the eradication of smallpox

September 24, 2019 - 14:52 -- Open Access
Author(s): 
Justin M. Cohen
Reference: 
Malaria Journal 2019 18:323, 23 September 2019

Malaria elimination and eventual eradication will require internationally coordinated approaches; sustained engagement from politicians, communities, and funders; efficient organizational structures; innovation and new tools; and well-managed programmes. As governments and the global malaria community seek to achieve these goals, their efforts should be informed by the substantial past experiences of other disease elimination and eradication programmes, including that of the only successful eradication programme of a human pathogen to date: smallpox.

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Getting ready for integrated vector management for improved disease prevention in Zimbabwe: a focus on key policy issues to consider

September 24, 2019 - 14:50 -- Open Access
Author(s): 
Shadreck Sande, Moses Zimba, David Nyasvisvo, Munyaradzi Mukuzunga, Emmanuel H. Kooma, Joseph Mberikunashe and Busisani Dube
Reference: 
Malaria Journal 2019 18:322, 23 September 2019

This paper outlines Zimbabwe’s potential readiness in harnessing integrated vector management (IVM) strategy for enhanced control of vector-borne diseases. The objective is to provide guidance for the country in the implementation of the national IVM strategy in order to make improvements required in thematic areas of need. The paper also assesses the existing opportunities and gaps to promote and adopt the approach as a national policy.

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