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Scientific Articles

NOT Open Access | Regional variation and demographic factors associated with knowledge of malaria risk and prevention strategies among pregnant women in Nigeria

April 6, 2020 - 08:41 -- NOT Open Access
Iyanda AE, Osayomi T, Boakye KA, Lu Y
Women & Health, Volume 60, 2020 - Issue 4

Pregnant women and children are the most vulnerable populations for malaria infection. Yet, knowledge of risk, and preventive measures are poor among this population. Using the 2015 Nigeria Malaria Indicator Survey, we applied logit link function to estimate the associations of wealth status, educational attainment, and region of residence with malaria risk knowledge and prevention strategies (using a treated mosquito net and malaria drugs) among 739 Nigerian pregnant women aged 15–49 years.

NOT Open Access | Skeleton binding protein 1 (SBP1) of Plasmodium falciparum accumulates in electron-dense material before passing through the parasitophorous vacuole membrane

April 6, 2020 - 08:39 -- NOT Open Access
Iriko H, Ishino T, Tachibana M, Omoda A, Torii M, Tsuboi T
Parasitology International, Volume 75, April 2020, 102003

Plasmodium falciparum proteins involved in vascular endothelial cell adherence are transported to the surface of infected erythrocytes. These proteins are exported through parasite-derived membrane structures within the erythrocyte cytoplasm called Maurer's clefts. Skeleton binding protein 1 (SBP1) is localized in the Maurer's clefts and plays an important role in transporting molecules to the surface of infected erythrocytes.

NOT Open Access | The transportome of the malaria parasite

April 6, 2020 - 08:37 -- NOT Open Access
Martin RE
Biol Rev Camb Philos Soc. 2020 Apr;95(2):305-332

Membrane transport proteins, also known as transporters, control the movement of ions, nutrients, metabolites, and waste products across the membranes of a cell and are central to its biology. Proteins of this type also serve as drug targets and are key players in the phenomenon of drug resistance.

NOT Open Access | Effects of inorganic fertilizer on larval development, adult longevity and insecticide susceptibility in the malaria vector Anopheles arabiensis (Diptera: Culicidae)

April 6, 2020 - 08:35 -- NOT Open Access
Samuel M, Brooke BD, Oliver SV
Pest Manag Sci. 2020 Apr;76(4):1560-1568

Exposure to inorganic fertilizer is common for the major malaria vector Anopheles arabiensis, which is closely associated with agricultural activities. The aim of this study was to understand if insecticide susceptible and resistant individuals respond to fertilizer exposure in the same manner. Two laboratory strains, SENN, an insecticide susceptible strain, and SENN‐DDT, an insecticide resistant strain selected strain selected from SENN, were used in this study. Both strains were exposed to one of three concentrations of a combination nitrogen‐phosphorus‐potassium (NPK) inorganic fertilizer, as well as nitrogenous (urea), phosphorus (superphosphate) and kaelic (potassium chloride, KCl) elemental fertilizer. The time to pupation was monitored, adult longevity was assessed and the insecticide tolerance of adults was determined. The effect of elemental fertilizers on ovipositioning site choice was also assessed.

Ivermectin as a novel complementary malaria control tool to reduce incidence and prevalence: a modelling study

April 6, 2020 - 08:30 -- Open Access
Slater HC, Foy BD, Smit MR, et al.
Lancet Infect Dis. 2020 Apr;20(4):498-508

Ivermectin is a potential new vector control tool to reduce malaria transmission. Mosquitoes feeding on a bloodmeal containing ivermectin have a reduced lifespan, meaning they are less likely to live long enough to complete sporogony and become infectious. We aimed to estimate the effect of ivermectin on malaria transmission in various scenarios of use.

NOT Open Access | HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima

April 6, 2020 - 08:20 -- NOT Open Access
Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L
Nat Prod Res. 2020 Apr;34(7):1037-1040

Seven tetracyclic spiro-alkaloids, i.e. glucoerysodine (1), erysodine (2), epi-erythratidine (3), erysovine (4), erythratidine (5), erysotrine (6) and erythraline (7) were isolated from the seeds of Erythrina latissima by means of conventional separation methods and HPLC-DAD-SPE-NMR. Their structures were elucidated by spectroscopic means.

Amount of Brain Edema Correlates With Neurologic Recovery in Pediatric Cerebral Malaria

April 6, 2020 - 08:18 -- Open Access
Kampondeni S, Seydel KB, Zhang B, Small DS, Birbeck GL, Hammond CA, Chilingulo C, Taylor TE, Potchen MJ
Pediatr Infect Dis J. 2020 Apr;39(4):277-282

Cerebral malaria (CM) remains a leading cause of mortality and morbidity in children in sub-Saharan Africa. Recent studies using brain magnetic resonance imaging have revealed increased brain volume as a major predictor of death. Similar morphometric predictors of morbidity at discharge are lacking. The aim of this study was to investigate the utility of serial cranial cisternal cerebrospinal fluid (CSF) volume measurements in predicting morbidity at discharge in pediatric CM survivors.

Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon

April 6, 2020 - 08:16 -- Open Access
Siles C, Elson WH, Vilcarromero S, Morrison AC, Hontz RD, Alava F, Valdivia H, Felices V, Guevara C, Jenkins S, Abente EJ, Ampuero JS
Emerg Infect Dis. 2020 Apr;26(4):731-737

During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities.

The role of windows of selection and windows of dominance in the evolution of insecticide resistance in human disease vectors

April 6, 2020 - 08:15 -- Open Access
South A, Lees R, Garrod G, Carson J, Malone D, Hastings I
Evol Appl. 2019 Dec 10;13(4):738-751

Persistent insecticides sprayed onto house walls, and incorporated into insecticide‐treated bednets, provide long‐acting, cost‐effective control of vector‐borne diseases such as malaria and leishmaniasis. The high concentrations that occur immediately postdeployment may kill both resistant and susceptible insects.

Evaluation of Malaria Cases Detected in Antalya Province between 2012 and 2017

April 6, 2020 - 08:13 -- Open Access
Ser Ö
Turkiye Parazitol Derg. 2020 Mar 20;44(1):1-6

Malaria is an important infectious disease that is transmitted by female mosquitoes of the genus Anopheles infected with parasites of the genus Plasmodium. In this research, it was aimed to contribute to the ongoing studies on malaria control in Antalya.


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