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Scientific Articles

Dry season occurrence of Anopheles mosquitoes and implications in Jabi Tehnan District, West Gojjam Zone, Ethiopia

December 4, 2018 - 14:38 -- Open Access
Author(s): 
Abebe Animut and Yohannes Negash
Reference: 
Malaria Journal 2018 17:445, 29 November 2018

Streams were prolific breeding habitats of Anopheles mosquitoes followed by ponds and swamps in the dry seasons.

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Outreach training and supportive supervision for malaria case management in Zambia: the effects of focused capacity building on indicators of diagnostic and clinical performance

December 4, 2018 - 14:34 -- Open Access
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Author(s): 
Matt Worges, Nicole Whitehurst, Emanuel Yamo, Hawela Moonga, Joshua Yukich and Luis Benavente
Reference: 
Malaria Journal 2018 17:438, 28 November 2018

The external quality assurance scheme provided periodic representations of clinical and laboratory staff performance.

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Molecular identification of Plasmodium species responsible for malaria reveals Plasmodium vivax isolates in Duffy negative individuals from southwestern Nigeria

December 4, 2018 - 14:32 -- Open Access
Author(s): 
Mary Aigbiremo Oboh, Aida Sadikh Badiane, Godwin Ntadom, Yaye Die Ndiaye, Khadim Diongue, Mamadou Alpha Diallo and Daouda Ndiaye
Reference: 
Malaria Journal 2018 17:439, 28 November 2018

The present study gave the first molecular evidence of P. vivax in Nigeria in Duffy negative individuals.

Challenges for the diagnosis and treatment of malaria in low transmission settings in San Lorenzo, Esmeraldas, Ecuador

December 4, 2018 - 14:28 -- Open Access
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Author(s): 
Mayte Mosquera-Romero, Lina Zuluaga-Idárraga and Alberto Tobón-Castaño
Reference: 
Malaria Journal 2018 17:440, 28 November 2018

The network of diagnostic services for malaria is weak in San Lorenzo, and socio-economic, political and historical factors hinder the implementation of the universal malaria elimination strategy based on diagnosis and treatment.

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NOT Open Access | Synthesis, Biological Evaluation, and Molecular Modeling Studies of Chiral Chloroquine Analogues as Antimalarial Agents

November 28, 2018 - 15:58 -- NOT Open Access
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Author(s): 
Srinivasarao Kondaparla, Utsab Debnath, Awakash Soni, Vasantha Rao Dola, Manish Sinha, Kumkum Srivastava, Sunil K. Puri and Seturam B. Katti
Reference: 
Antimicrob. Agents Chemother. December 2018 62:e02347-17

In a focused exploration, we designed, synthesized, and biologically evaluated chiral conjugated new chloroquine (CQ) analogues with substituted piperazines as antimalarial agents.

Medical Treatment: 

NOT Open Access | Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria

November 28, 2018 - 15:43 -- NOT Open Access
Author(s): 
Liezl Gibhard, Mathew Njoroge, Gregory S. Basarab, et al.
Reference: 
Antimicrob. Agents Chemother. December 2018 62:e00261-18

The in vivo antimalarial efficacies of two phosphatidylinositol 4-kinase (PI4K) inhibitors, a 3,5-diaryl-2-aminopyrazine sulfoxide and its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rγnull (NSG) murine malaria disease model of Plasmodium falciparum infection.

NOT Open Access | In Silico Investigation of the Decline in Clinical Efficacy of Artemisinin Combination Therapies Due to Increasing Artemisinin and Partner Drug Resistance

November 28, 2018 - 15:41 -- NOT Open Access
Author(s): 
Sophie G. Zaloumis, Pengxing Cao, Julie A. Simpson, et al.
Reference: 
Antimicrob. Agents Chemother. December 2018 62:e01292-18

Antimalarial treatment currently relies on an artemisinin derivative and a longer-acting partner drug.

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Neddylation contributes to CD4+ T cell-mediated protective immunity against blood-stage Plasmodium infection

November 28, 2018 - 15:26 -- Open Access
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Author(s): 
Qianqian Cheng, Jian Liu, Yujun Pei, Yaolin Zhang, Dawang Zhou, Weiqing Pan, Jiyan Zhang
Reference: 
PLoS Pathog 14(11): e1007440

Plasmodium infection, both for IFN-γ-dependent effector mechanisms and providing B cell helper signals.

NOT Open Access | Identification of potential whole blood MicroRNA biomarkers for the blood stage of adult imported falciparum malaria through integrated mRNA and miRNA expression profiling

November 28, 2018 - 15:25 -- NOT Open Access
Author(s): 
Jing-jing Li, Min-jun Huang, Zhen Li, Wei Li, Fei Wang, Lei Wang, Xiao-li Li, Xiaoyan Zheng, Yang Zou
Reference: 
Biochemical and Biophysical Research Communications Volume 506, Issue 3, 30 November 2018, Pages 471-477

Correlating aberrant miRNA levels with imported malaria during the blood stage is required to better understand the in vivo biological and molecular processes that are involved in the response to Plasmodium falciparum infection and to find new biomarkers and diagnosis tools.

Controlled release spatial repellent devices (CRDs) as novel tools against malaria transmission: a semi-field study in Macha, Zambia

November 27, 2018 - 15:34 -- Open Access
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Author(s): 
Jennifer C. Stevenson, Limonty Simubali, Noel M. Elman, et al.
Reference: 
Malaria Journal 2018 17:437, 26 November 2018

This study demonstrated that deployment of as few as four CRDs within a hut was associated with reduced indoor mosquito densities.

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