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Scientific Articles

The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases

Tags:

artemisia annua L, artemisinin-type drug, autoimmune disease, malaria

Author(s):

Efferth T, Oesch F

Reference:

Med Res Rev. 2021 Jul 21

The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α), β3-integrin, or RANKL, toll-like receptors and growth factor receptors.

Impact of asymptomatic Plasmodium falciparum infection on the risk of subsequent symptomatic malaria in a longitudinal cohort in Kenya

Tags:

plasmodium falciparum, symptomatic, malaria, Kenya

Author(s):

Sumner KM, Mangeni JN, Obala AA, Freedman E, Abel L, Meshnick SR, Edwards JK, Pence BW, Prudhomme-O'Meara W, Taylor SM

Reference:

Elife. 2021 Jul 23;10:e68812

Asymptomatic Plasmodium falciparum infections are common in sub-Saharan Africa, but their effect on subsequent symptomaticity is incompletely understood.

NOT Open Access | Efficacy of Chininum Sulphuricum 30C against Malaria: An in vitro and in vivo Study

Tags:

antiplasmodial activit, malaria, multi-drug-resistant, p.falciparum

Author(s):

Suri M, Katnoria S, Walter NS, Manchanda RK, Khurana A, Nayak D, Bagai U, Kaur S

Reference:

Complement Med Res. 2021 Jul 27:1-10

New effective, economical and safe antimalarial drugs are urgently needed due to the development of multi-drug-resistant strains of the parasite. Homeopathy uses ultra-diluted doses of various substances to stimulate autoregulatory and self-healing processes to cure various ailments. The aim of the study was to evaluate the in vitro and in vivo antimalarial efficacy of a homeopathic drug, Chininum sulphuricum 30C.

NOT Open Access | High genetic complexity but low relatedness in Plasmodium falciparum infections from Western Savannah Highlands and coastal equatorial Lowlands of Cameroon

Tags:

plasmodium falciparum, prevalence, malaria, Cameroon

Author(s):

Atuh NI, Anong DN, Jerome FC, Oriero E, Mohammed NI, D'Alessandro U, Amambua-Ngwa A

Reference:

Pathog Glob Health. 2021 Jul 26:1-10

To determine the diversity and connectivity of infections in Northwestern and Southwestern Cameroon, 232 Plasmodium falciparum infections, collected in 2018 from the Ndop Health District (NHD) in the western savannah highlands in the Northwest and the Limbe Health District (LHD) in the coastal lowland forests in the Southwest of Cameroon were genotyped for nine neutral microsatellite markers.

NOT Open Access | Microwave-assisted synthesis of hybrid PABA-1,3,5-triazine derivatives as an antimalarial agent

Tags:

plasmodium falciparum, PABA, antimalarial agent, chloroquine

Author(s):

Kashyap A, Choudhury AAK, Saha A, Adhikari N, Ghosh SK, Shakya A, Patgiri SJ, Bhattacharyya DR, Singh UP, Bhat HR

Reference:

J Biochem Mol Toxicol. 2021 Jul 27:e22860

The present manuscript deals with the development of novel p-aminobenzoic acid (PABA) associated 1,3,5-triazine derivatives as antimalarial agents. The molecules were developed via microwave-assisted synthesis and structures of compounds were ascertained via numerous analytical and spectroscopic techniques. The synthesized compounds were also subjected to ADMET analysis.

NOT Open Access | Chloroquine inhibits pro-inflammatory effects of heme on macrophages and invivo

Tags:

malaria, plasmodium sp., chloroquine, pro-inflammatory effect

Author(s):

Silva RCMC, Tan L, Rodrigues DA, Prestes EB, Gomes CP, Gama AM, Oliveira PL, Paiva CN, Manoury B, Bozza MT

Reference:

Free Radic Biol Med. 2021 Jul 22;173:104-116

Chloroquine has been used successfully to treat Malaria, including by chloroquine-resistant Plasmodium sp., indicating that it has effects on disease itself. Since heme has inflammatory effects and contributes to the pathogenesis of hemolytic diseases, we hypothesize that the anti-inflammatory effect of chloroquine is partially due to its inhibitory effect on heme-induced macrophage activation and on inflammatory tissue damage.

NOT Open Access | The pharmacokinetic properties of artemether and lumefantrine in Malaysian patients with Plasmodium knowlesi malaria

Tags:

artemether, lumefantrine, Malaysia, Plasmodium knowlesi, malaria

Author(s):

Sugiarto SR, Singh B, Page-Sharp M, Davis WA, Salman S, Hii KC, Davis TME

Reference:

Br J Clin Pharmacol. 2021 Jul 23

To assess the pharmacokinetic properties of artemether, lumefantrine and their active metabolites in Plasmodium knowlesi malaria.

The effects of malaria in pregnancy on neurocognitive development in children at one and six years of age in Benin: a prospective mother-child cohort

Tags:

malaria, children, Benin, MiP, sub-Saharan Africa

Author(s):

Garrison A, Boivin MJ, Fiévet N, Zoumenou R, Alao JM, Massougbodji A, Cot M, Bodeau-Livinec F

Reference:

Clin Infect Dis. 2021 Jul 23:ciab569

Malaria in pregnancy (MiP) contributes significantly to infant mortality rates in Sub-Saharan Africa and has consequences on survivors, such as pre-term birth and low birth weight. However, its impact on long-term neurocognitive development in children remains unknown.

Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

Tags:

malaria, Plasmodium vivax, SLC3A2, red blood cells

Author(s):

Malleret B, El Sahili A, Rénia L, et al.

Reference:

Nat Microbiol 6, 991–999 (2021)

More than one-third of the world's population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2-4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6-10.