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Scientific Articles

NOT Open Access | Changes in malaria epidemiology in France and worldwide, 2000-2015

March 9, 2020 - 13:39 -- NOT Open Access
Thellier M, Simard F, Musset L, Cot M, Velut G, Kendjo E, Pradines B
Médecine et Maladies Infectieuses, Volume 50, Issue 2, March 2020, Pages

In 2015, 212 million new cases of malaria were reported, causing 429,000 deaths. The World Health Organization (WHO) estimated a 41% decrease in the number of new cases worldwide between 2000 and 2015. The number of deaths from malaria fell by 62% worldwide and by 71% in Africa. In mainland France, malaria is mainly imported by travelers or migrants from endemic areas, in particular sub-Saharan Africa (95%).

Growth Rate of Plasmodium falciparum: Analysis of Parasite Growth Data From Malaria Volunteer Infection Studies

March 9, 2020 - 13:37 -- Open Access
Wockner LF, Hoffmann I, Webb L, Mordmüller B, Murphy SC, Kublin JG, O'Rourke P, McCarthy JS, Marquart L
The Journal of Infectious Diseases, Volume 221, Issue 6, 15 March 2020, Pages 963–972

Growth rate of malaria parasites in the blood of infected subjects is an important measure of efficacy of drugs and vaccines.

An Experimental Human Blood-Stage Model for Studying Plasmodium malariae Infection

March 9, 2020 - 13:35 -- Open Access
Woodford J, Collins KA, Odedra A, Wang C, Jang IK, Domingo GJ, Watts R, Marquart L, Berriman M, Otto TD, McCarthy JS
The Journal of Infectious Diseases, Volume 221, Issue 6, 15 March 2020, Pages 948–955

Plasmodium malariae is considered a minor malaria parasite, although its global disease burden is underappreciated. The aim of this study was to develop an induced blood-stage malaria (IBSM) model of P. malariae to study parasite biology, diagnostic assays, and treatment.

NOT Open Access | Ivermectin for causal malaria prophylaxis: a randomised controlled human infection trial

March 9, 2020 - 13:32 -- Kabogo Ndegwa
Metzger WG, Theurer A, Pfleiderer A, Molnar Z, Maihöfer-Braatting D, Bissinger AL, Sulyok Z, Köhler C, Egger-Adam D, Lalremruata A, Esen M, Lee Sim K, Hoffman S, Rabinovich R, Chaccour C, Alonso P, Mordmüller BG, Kremsner PG
Tropical Medicine and International Health Volume 25, Issue 3, March 2020, Pages 380-386

Ivermectin is safe and widely used for treating helminth infections. It also kills arthropods feeding on treated subjects, including malaria vectors. Thus, ivermectin mass drug administration as an additional tool for malaria control is being evaluated by WHO. As in vitro data, animal experiments and epidemiological observations suggest that ivermectin has a direct effect on the liver stages of the malaria parasite, this study was designed to assess the prophylactic effect of ivermectin on Plasmodium falciparum controlled human malaria infection.

NOT Open Access | Identification of essential exported Plasmodium falciparum protein kinases in malaria-infected red blood cells

March 6, 2020 - 09:06 -- NOT Open Access
Siddiqui G, Proellochs NI, Cooke BM
Br J Haematol Volume 188, Issue 5, March 2020

FIKK kinases in the human malaria parasite Plasmodium falciparum are attractive targets for new anti‐malaria drugs, as they have no orthologues in humans and have been linked to disease severity. Six FIKKs are known to be exported into red blood cells (RBCs) where they mediate dramatic structural and functional changes to RBCs that are central to pathogenesis. Eleven members of this family, which are predicted to be exported into infected RBCs (iRBCs), remain uncharacterised.

NOT Open Access | Management and prevention of imported malaria in children. Update of the French guidelines

March 6, 2020 - 09:01 -- NOT Open Access
Leblanc C, Vasse C, Minodier P, Mornand P, Naudin J, Quinet B, Siriez JY, Sorge F, de Suremain N, Thellier M, Kendjo E, Faye A, Imbert P
Médecine et Maladies Infectieuses, Volume 50, Issue 2, March 2020, Pages 127-140

Since the 2007 French guidelines on imported Falciparum malaria, the epidemiology, treatment, and prevention of malaria have changed considerably requiring guidelines for all Plasmodium species to be updated. Over the past decade, the incidence of imported malaria has decreased in all age groups, reflecting the decrease in the incidence of malaria in endemic areas. The rates of severe pediatric cases have increased as in adults, but fatalities are rare.

NOT Open Access | Is there a role for bedside ultrasound in malaria? A survey of the literature

March 6, 2020 - 08:37 -- NOT Open Access
Malerba P, Kaminstein D, Brunetti E, Manciulli T
J Ultrasound. 2020 Mar;23(1):13-21

Point-of-care ultrasound (POCUS) has proven utility in the evaluation and treatment of many tropical diseases. Its role in malaria has been studied, but its value for the clinician at the bedside is unclear. Our review aimed at summarizing the existing studies to assess the usefulness, if any, of POCUS in treating malaria.

NOT Open Access | Management and treatment of uncomplicated imported malaria in adults. Update of the French malaria clinical guidelines

March 3, 2020 - 15:15 -- NOT Open Access
Epelboin L, Rapp C, Faucher JF, Méchaï F, Bottieau E, Matheron S, Malvy D, Caumes E
Med Mal Infect. 2020 Mar;50(2):194-212


  • The diagnosis of malaria should always be considered in travelers returning from an endemic area and presenting with fever or a history of fever, either isolated or combined with other general, digestive, and/or respiratory symptoms, even if appropriate chemoprophylaxis was used.
  • Outpatient management of uncomplicated Plasmodium falciparum malaria may be implemented if precise clinical and biological criteria are met and if medical follow-up is possible.

NOT Open Access | An approach to natural insect repellent formulations: from basic research to technological development

March 3, 2020 - 15:14 -- NOT Open Access
da Silva MRM, Ricci-Júnior E
Acta Trop. 2020 Feb 28:105419

The incidence of dengue, Zika, chikungunya, yellow fever and malaria cases has increased significantly in the world. To avoid mosquito bites, one of the best strategies is the use of repellents. The interest in using plants as mosquito repellents has increased significantly. In this review, has been performed a bibliographic survey of the plants with repellent activity, evaluate the trends of natural repellent formulations in the scientific literature, those described in patents and commercially available products.

Plasmodium vivax transcriptional profiling of low input cryopreserved isolates through the intraerythrocytic development cycle

March 3, 2020 - 15:13 -- Open Access
Rangel GW, Clark MA, Kanjee U, Goldberg JM, MacInnis B, José Menezes M, Ferreira MU, Duraisingh MT
PLoS Negl Trop Dis 14(3): e0008104

Approximately one-third of the global population is at risk of Plasmodium vivax infection, and an estimated 7.51 million cases were reported in 2017. Although, P. vivax research is currently limited by the lack of a robust continuous in vitro culture system for this parasite, recent work optimizing short-term ex vivo culture of P. vivax from cryopreserved isolates has facilitated quantitative assays on synchronous parasites.


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