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Scientific Articles

An integrated dataset of malaria notifications in the Legal Amazon

June 6, 2020 - 15:04 -- Open Access
Baroni L, Pedroso M, Barcellos C, Salles R, Salles S, Paixão B, Chrispino A, Guedes G, Ogasawara E
BMC Res Notes. 2020 Jun 3; 13(1):274

Malaria is an infectious disease that annually presents around 200,000 cases in Brazil. The availability of data on malaria is crucial for enabling and supporting studies that can promote actions to prevent it. Therefore, the goal of this paper is to contribute to such studies by offering an integrated dataset containing data on reported and suspected cases of malaria in the Brazilian Legal Amazon comprising the period from the years 2009 to 2019.

How to Estimate Optimal Malaria Readiness Indicators at Health-District Level: Findings from the Burkina Faso Service Availability and Readiness Assessment (SARA) Data

June 6, 2020 - 14:56 -- Open Access
Rouamba T, Samadoulougou S, Compaoré CS, Tinto H, Gaudart J, Kirakoya-Samadoulougou F
Int J Environ Res Public Health. 2020 Jun 1;17(11):E3923

One of the major contributors of malaria-related deaths in Sub-Saharan African countries is the limited accessibility to quality care. In these countries, malaria control activities are implemented at the health-district level (operational entity of the national health system), while malaria readiness indicators are regionally representative. This study provides an approach for estimating health district-level malaria readiness indicators from survey data designed to provide regionally representative estimates.

Evaluation of boric acid as toxic sugar bait against resistant Aedes aegypti mosquitoes

June 6, 2020 - 14:52 -- Open Access
Pearson MA, Blore K, Efstathion C, Aryaprema VS, Muller GC, Xue RD, Qualls WA
J Vector Ecol. 2020 Jun;45(1):100-103

Current methods of broad area application of contact insecticides used in mosquito control are becoming less effective, primarily due to resistance within mosquito populations. New methods that can deliver ingestible insecticides are being investigated as a means to mitigate resistance.

Mosquito community composition and abundance at contrasting sites in northern South Africa, 2014-2017

June 6, 2020 - 14:50 -- Open Access
Johnson T, Braack L, Guarido M, Venter M, Gouveia Almeida AP
J Vector Ecol. 2020 Jun; 45(1):104-117

Most data on species associations and vector potential of mosquitoes in relation to arboviral infections in South Africa date back from the 1940s to late 1990s. Contextual information crucial for disease risk management and control, such as the sampling effort, diversity, abundance, and distribution of mosquitoes in large parts of South Africa still remains limited. Adult mosquitoes were collected routinely from two horse farms in Gauteng Province; two wildlife reserves in Limpopo Province, at Orpen Gate in Kruger National Park (KNP) and Mnisi Area in Mpumalanga Province between 2014–2017, using carbon dioxide‐baited light and tent traps.

NOT Open Access | von Willebrand factor increases in experimental cerebral malaria but is not essential for late-stage pathogenesis in mice

June 3, 2020 - 16:01 -- NOT Open Access
Kraisin S, Martinod K, Desender L, Pareyn I, Verhenne S, Deckmyn H, Vanhoorelbeke K, Van den Steen PE, De Meyer SF
J Thromb Haemost. 2020 Jun 2

Cerebral malaria (CM) is the most severe complication in malaria. Endothelial activation, cytokine release and vascular obstruction are essential hallmarks of CM. Clinical studies have suggested a link between von Willebrand factor (VWF) and malaria pathology.

Malaria parasites regulate intra-erythrocytic development duration via serpentine receptor 10 to coordinate with host rhythms

June 3, 2020 - 15:54 -- Open Access
Subudhi AK, O'Donnell AJ, Pain A, et al.
Nat Commun. 2020 Jun 2; 11(1):2763

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 h suggesting a circadian basis, but the mechanism controlling this periodicity is unknown.

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

June 3, 2020 - 15:52 -- Open Access
Toda H, Diaz-Varela M, Del Portillo HA, et al.
Nat Commun. 2020 Jun 2; 11(1):2761

Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular vesicles (EVs) are therefore major components of circulating plasma holding insights into pathological processes. Here, we demonstrate that plasma-derived EVs from Plasmodium vivax patients (PvEVs) are preferentially uptaken by human spleen fibroblasts (hSFs) as compared to the uptake of EVs from healthy individuals.

Rrp6 Regulates Heterochromatic Gene Silencing via ncRNA RUF6 Decay in Malaria Parasites

June 3, 2020 - 15:47 -- Open Access
Fan Y, Shen S, Zhang Q, et al.
mBio. 2020 Jun 2; 11(3):e01110-20

The heterochromatin environment plays a central role in silencing genes associated with the malaria parasite’s development, survival in the host, and transmission to the mosquito vector. However, the underlying mechanism regulating the dynamic chromatin structure is not understood yet. Here, we have uncovered that Plasmodium falciparum Rrp6, an orthologue of eukaryotic RNA exosome-associated RNase, controls the silencing of heterochromatic genes.

NOT Open Access | Distribution of CD36 deficiency in different Chinese ethnic groups

June 3, 2020 - 15:45 -- NOT Open Access
Liu J, Shao Y, Ding H, Deng J, Xu X, Wang J, Xia W, Santoso S, Ye X, Fu Y
Hum Immunol. 2020 May 30:S0198-8859(20)30316-5

CD36 is a multifunctional receptor in cells that plays a role in important cellular processes including immune regulation. Evidence indicates that mutations in the CD36 gene are associated with malaria. Moreover, studies on the frequency of CD36 deficiency have been conducted in specific provinces of China. However, the frequency of CD36 deficiency may differ among various ethnic populations. In this study, we analyzed the frequency of CD36 deficiency among seven different provinces and minorities in China.

Community factors affecting participation in larval source management for malaria control in Chikwawa District, Southern Malawi

June 3, 2020 - 15:42 -- Open Access
Steven Gowelo, Robert S. McCann, Constantianus J. M. Koenraadt, Willem Takken, Henk van den Berg and Lucinda Manda-Taylor
Malaria Journal 2020 19:195, 2 June 2020

To further reduce malaria, larval source management (LSM) is proposed as a complementary strategy to the existing strategies. LSM has potential to control insecticide resistant, outdoor biting and outdoor resting vectors. Concerns about costs and operational feasibility of implementation of LSM at large scale are among the reasons the strategy is not utilized in many African countries. Involving communities in LSM could increase intervention coverage, reduce costs of implementation and improve sustainability of operations. Community acceptance and participation in community-led LSM depends on a number of factors. These factors were explored under the Majete Malaria Project in Chikwawa district, southern Malawi.


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