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Scientific Articles

Open Access | Case report: Plasmodium malariae in Bangladesh

December 3, 2009 - 11:47 -- Patrick Sampao
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Author(s): 
W. Rahman, K. Chotivanich, K. Silamut, N. Tanomsing, A. Hossain, M.A. Faiz, A.M. Dondorp, R.J. Maude
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 1, January 2010, Pages 78-80, doi:10.1016/j.trstmh.2009.06.014

We describe a 32-year-old Bangladeshi male presenting with severe malaria caused by a mono-infection with Plasmodium malariae. 

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An imported case of P. falciparum malaria presenting as black water fever with acute renal failure

December 3, 2009 - 09:51 -- Patrick Sampao
Author(s): 
Fahmi Yousef Khan, Dalia Al-Haddada
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Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 378-380, doi:10.1016/j.tmaid.2009.11.002

This is a report of a case of blackwater fever in a 28-year-old Nigerian man who was admitted to hospital with fever, jaundice and passing dark urine. Abdominal examination revealed splenomegaly and an examination of the peripheral smear of the patient showed the ring form of the trophozoites of Plasmodium falciparum (P. falciparum). Serum creatinine was 200 μmol/L. Treatment with quinine and doxycycline was started and intravenous fluids were administered with close monitoring of the urine output and serum electrolytes.

Evaluation of simian adenoviral vector AdCh63 expressing MSP-1 as a candidate blood-stage malaria vaccine

December 3, 2009 - 09:34 -- Patrick Sampao
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Author(s): 
Anna Goodman, Sarah Gilbert, Stefano Colloca, Matthew Dicks, Adrian Hill, Simon Draper
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Journal of Infection, Volume 59, Issue 6, December 2009, Pages S427-S428, doi:10.1016/j.jinf.2009.10.008

No abstract available.

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Spurious Amplification of a Plasmodium vivax Small-Subunit RNA Gene by Use of Primers Currently Used To Detect P. knowlesi

December 3, 2009 - 09:28 -- Patrick Sampao
Author(s): 
Mallika Imwong, Naowarat Tanomsing, Sasithon Pukrittayakamee, Nicholas P. J. Day, Nicholas J. White, and Georges Snounou
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Journal of Clinical Microbiology, December 2009, p. 4173-4175, Vol. 47, No. 12, doi:10.1128/JCM.00811-09

A nested primer set that targets one of the P. knowlesi small-subunit rRNA genes was validated for specificity and for sensitivity of detection of <10 parasite genomes.

Nitric oxide is an essential component of the hemocyte-mediated mosquito immune response against bacteria

December 3, 2009 - 09:22 -- Patrick Sampao
Author(s): 
Julián F. Hillyer, Tania Y. Estévez-Lao
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Developmental & Comparative Immunology, Volume 34, Issue 2, February 2010, Pages 141-149, doi:10.1016/j.dci.2009.08.014

Here, we characterized the temporal and spatial expression of the Anopheles gambiae nitric oxide synthase gene and explored the role nitric oxide plays in the antibacterial response in the mosquito hemocoel.

Lessons learned: Difficulties in organizing first indoor spray programme against malaria in Angola under the President’s Malaria Initiative

December 2, 2009 - 09:39 -- Ingeborg van Schayk
Author(s): 
Martinho Somandjinga a, Manuel Lluberas b & William R Jobin c
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Bulletin of the World Health Organization 2009;87:871-874. doi: 10.2471/BLT.08.052514

The first PMI programme to control malaria in Africa failed to have an impact in southern Angola because of hurried and inadequate preparation, based primarily on administrative reports of malaria prevalence.

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Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern Tanzania

November 30, 2009 - 15:03 -- Ingeborg van Schayk
Author(s): 
Bruno P Mmbando, John P Lusingu, Lasse S Vestergaard, Martha M Lemnge, Thor G Theander and Thomas H Scheike
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BMC Medical Research Methodology 2009, 9:75 doi:10.1186/1471-2288-9-75

This paper describes step function and dose response model with threshold parameter as a tool for estimation of parasite threshold for onset of malaria fever in highlands (low transmission) and lowlands (high transmission intensity) strata.

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Analysis of the phylogenetic relationship of Anopheles species, subgenus Cellia (Diptera: Culicidae) and using it to define the relationship of morphologically similar species

November 29, 2009 - 07:00 -- Patrick Sampao
Author(s): 
Amitav Mohanty, Sunita Swain, Santanu K. Kar, Rupenangshu K. Hazra.
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Infection, Genetics and Evolution, Volume 9, Issue 6, December 2009, Pages 1204-1224, doi:10.1016/j.meegid.2009.06.021

Studies on the relationship of various vectors and non-vectors of malaria from the evolutionary point of view are important. Use of molecular methods to define phylogeny helps to understand the interrelationship among the members of the anophelines and elucidate the ambiguity that has arisen from improper classification. It could also help to design molecular markers for species differentiation, particularly in those which pose difficulty when classified, based on morphological features.

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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial

November 27, 2009 - 14:30 -- Ingeborg van Schayk
Author(s): 
Roly Gosling , Samwel Gesase, Jacklin Mosha, Ilona Carneiro, Ramadhan Hashim, Martha Lemnge, Frank Mosha , Brian Greenwood, Daniel Chandramohan
Reference: 
The Lancet, Volume 374, Issue 9700, Pages 1521 - 1532, 31 October 2009, doi:10.1016/S0140-6736(09)60997-1

Administration of sulfadoxine-pyrimethamine at times of vaccination—intermittent preventive treatment in infants (IPTi)—is a promising strategy to prevent malaria. However, rising resistance to this combination is a concern. We investigated a shortacting and longacting antimalarial drug as alternative regimens for IPTi.

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