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Scientific Articles

Role of Plasmodium falciparum Digestive Vacuole Plasmepsins in the Specificity and Antimalarial Mode of Action of Cysteine and Aspartic Protease Inhibitors

December 7, 2009 - 11:51 -- Ingeborg van Schayk
Author(s): 
Pedro A. Moura, John B. Dame, and David A. Fidock
Reference: 
Antimicrob. Agents Chemother. 2009;53 4968-4978

Hemoglobin (Hb) degradation is essential for the growth of the intraerythrocytic stages of malarial parasites.

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Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies

December 7, 2009 - 11:26 -- Ingeborg van Schayk
Author(s): 
Maria Lazarou, Jose A. Guevara Patino, Richard M. Jennings, Richard S. McIntosh, Jianguo Shi, Steven Howell, Eilish Cullen, Tarran Jones, Jaime R. Adame-Gallegos, Jonathan A. Chappel, Jana S. McBride, Michael J. Blackman, Anthony A. Holder, and Richard J. Pleass
Reference: 
Infect. Immun. 2009;77 5659-5667

Antigen-specific antibodies (Abs) to the 19-kDa carboxy-terminal region of Plasmodium falciparum merozoite surface protein 1 (MSP119) play an important role in protective immunity to malaria.

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Vaccine Potentials of an Intrinsically Unstructured Fragment Derived from the Blood Stage-Associated Plasmodium falciparum Protein PFF0165c

December 7, 2009 - 11:20 -- Ingeborg van Schayk
Author(s): 
S. Olugbile, C. Kulangara, G. Bang, S. Bertholet, E. Suzarte, V. Villard, G. Frank, R. Audran, A. Razaname, I. Nebie, O. Awobusuyi, F. Spertini, A. V. Kajava, I. Felger, P. Druilhe, and G. Corradin
Reference: 
Infect. Immun. 2009;77 5701-5709

We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides, in vitro biological functional assays, and association of an antigen-specific antibody response with protection against clinical malaria.

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Malaria Ookinete Surface Protein-Based Vaccination via the Intranasal Route Completely Blocks Parasite Transmission in both Passive and Active Vaccination Regimens in a Rodent Model of Malaria Infection

December 7, 2009 - 11:12 -- Ingeborg van Schayk
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Author(s): 
Takeshi Arakawa, Mayumi Tachibana, Takeshi Miyata, Tetsuya Harakuni, Hideyasu Kohama, Yasunobu Matsumoto, Naotoshi Tsuji, Hajime Hisaeda, Anthony Stowers, Motomi Torii, and Takafumi Tsuboi
Reference: 
Infect. Immun. 2009;77 5496-5500

To our knowledge, this is the first time that mucosal vaccination has been demonstrated to be efficacious for directly preventing parasite transmission from vaccinated animals to mosquitoes, and the results may provide important insight into rational design of nonparenteral vaccines for use against human malaria.

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Open Access | Commentary: Knowlesi malaria in Vietnam

December 5, 2009 - 16:58 -- Ingeborg van Schayk
Tags: 
Author(s): 
Janet Cox-Singh
Reference: 
Malaria Journal 2009, 8:269 (26 November 2009)

However, there are many settings where knowlesi transmission to humans would be expected but is not found. A recent report on the Ra-glai population of southern central Vietnam is taken as an example to help explain why this may be so.

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Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

December 5, 2009 - 16:25 -- Kabogo Ndegwa
Author(s): 
Alvaro Mongui, Diana I. Angel, Gina Gallego, Claudia Reyes, Paola Martinez, Felipe Guhl, Manuel A. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 415-421, doi:10.1016/j.vaccine.2009.10.034

This study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34.

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Correspondence: Diagnostic importance of headache as a key symptom in suspecting malaria in adult returning travelers

December 5, 2009 - 16:21 -- Patrick Sampao
Author(s): 
Francisco M. Pherez, Burke A. Cunha
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 383-384. doi:10.1016/j.tmaid.2009.09.004

No abstract available.

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Evaluation of the safety and immunogenicity of Plasmodium falciparum apical membrane antigen 1, merozoite surface protein 1 or RTS, S vaccines with adjuvant system AS02A administered alone or concurrently in rhesus monkeys

December 5, 2009 - 16:19 -- Kabogo Ndegwa
Author(s): 
S. Pichyangkul, P. Tongtawe, U. Kum-Arb, K. Yongvanitchit, M. Gettayacamin, M.R. Hollingdale, A. Limsalakpetch, V.A. Stewart, D.E. Lanar, S. Dutta, E. Angov, L.A Ware, E.S. Bergmann-Leitner, B. House, G. Voss, M.C. Dubois, J.D. Cohen, M.M. Fukuda, D.G. Heppner, R.S. Miller.
Reference: 
Vaccine, Volume 28, Issue 2, 11 December 2009, Pages 452-462, doi:10.1016/j.vaccine.2009.10.022

In an effort to broaden the immune response induced by the RTS,S/AS02A,vaccine, we have evaluated the immunogenicity of the RTS,S antigen when combined with MSP142 and with AMA1, antigens derived from the asexual blood stage.

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Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: Retrospective observational data

December 4, 2009 - 16:07 -- Patrick Sampao
Author(s): 
Jane N. Zuckerman, Anthony J. Batty, Michael E. Jones.
Reference: 
Travel Medicine and Infectious Disease, Volume 7, Issue 6, November 2009, Pages 329-336, doi:10.1016/j.tmaid.2009.10.002.

Further work is required to ascertain whether ease of use and compliance may be important factors in the outcomes associated with malariachemoprophylaxis.

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