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Scientific Articles

Open Access | Plasmodium falciparum: hrp3 promoter region is associated with stage-specificity and episomal recombination

December 8, 2009 - 12:47 -- Ingeborg van Schayk
Author(s): 
López-Estraño C, Semblat JP, Gopalakrishnan AM, Turner L, Mazier D, Haldar K.
Reference: 
Exp Parasitol. 2007 Jul;116(3):327-33

Our results describe a ring-stage specific regulatory region possibly involved in episomal promoter recombination, suggesting that common sequences might mediate both processes.

Open Access | An enhancer-like region regulates hrp3 promoter stage-specific gene expression in the human malaria parasite Plasmodium falciparum

December 8, 2009 - 12:39 -- Ingeborg van Schayk
Author(s): 
López-Estraño C, Gopalakrishnan AM, Semblat JP, Fergus MR, Mazier D, Haldar K.
Reference: 
Biochim Biophys Acta. 2007 Jul-Aug;1769(7-8):506-13

The data presented in this study demonstrates that stage specific promoter activity of the hrp3 gene in P. falciparum blood stage parasites is supported, at least in-part, by a small promoter region that can function in the absence of a larger chromosomal context.

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Open Access | A simple method for defining malaria seasonality

December 8, 2009 - 12:38 -- Ingeborg van Schayk
Author(s): 
Arantxa Roca-Feltrer, Joanna RM Armstrong Schellenberg, Lucy Smith, Ilona Carneiro
Reference: 
Malaria Journal 2009, 8:276 (3 December 2009)

This is an interesting paper addressing the under-researched and important topic of seasonality in clinical malaria. It contains a lot of valuable data on the topic.

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Plasmodium falciparum: Preinitiation complex occupancy of active and inactive promoters during erythrocytic stage

December 8, 2009 - 12:30 -- Ingeborg van Schayk
Author(s): 
Anusha M. Gopalakrishnan, Lilian A. Nyindodo, M. Ross Fergus and Carlos López-Estraño
Reference: 
Experimental Parasitology Volume 121, Issue 1, January 2009, Pages 46-54

We used Chromatin immunoprecipitation (ChIP) to study interaction of PfTBP and PfTFIIE with stage specific Plasmodium promoters. Our results indicate that PfTBP and PfTFIIE are bound to their cognate sequence in active and inactive erythrocytic-expressed promoters.

Open Access | Quality of malaria case management at outpatient health facilities in Angola

December 8, 2009 - 12:30 -- Ingeborg van Schayk
Author(s): 
Alexander K Rowe, Gabriel F Ponce de Leon, Jules Mihigo, Ana Carolina FS Santelli, Nathan P Miller, Pedro Van-Dunem
Reference: 
Malaria Journal 2009, 8:275 (2 December 2009)

As problems identified in this survey are not unique to Angola, better strategies for improving Health Workers performance are urgently needed.

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Open Access | Comparison of surveillance methods applied to a situation of low malaria prevalence at rural sites in The Gambia and Guinea Bissau

December 8, 2009 - 12:22 -- Ingeborg van Schayk
Author(s): 
Judith Satoguina, Brigitte Walther, Christopher Drakeley, Davis Nwakanma, Eniyou C Oriero, Simon Correa, Patrick Corran, David J Conway, Michael Walther
Reference: 
Malaria Journal 2009, 8:274 (2 December 2009)

This study aims to provide parasite prevalence data from three sites in the Gambia and Guinea Bissau, respectively, and compares the usefulness of PCR, rapid diagnostic tests (RDT), serology and slide-microscopy for surveillance.

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Open Access | Impaired everyday memory associated with encephalopathy of severe malaria: the role of seizures and hippocampal damage

December 8, 2009 - 12:07 -- Ingeborg van Schayk
Author(s): 
Michael Kihara, Julie A Carter, Penny A Holding, Faraneh Vargha-Khadem, Rod C Scott, Richard Idro, Greg W Fegan, Michelle de Haan, Brian GR Neville, Charles RJC Newton
Reference: 
Malaria Journal 2009, 8:273 (1 December 2009)

It was hypothesized that severe malaria causes impaired everyday memory, which may be associated with hippocampal damage.

Open Access | Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children

December 8, 2009 - 11:55 -- Ingeborg van Schayk
Author(s): 
Shereen Katrak, Anne Gasasira, Emmanuel Arinaitwe, Abel Kakuru, Humphrey Wanzira, Victor Bigira, Taylor G Sandison, Jaco Homsy, Jordan W Tappero, Moses R Kamya, Grant Dorsey
Reference: 
Malaria Journal 2009, 8:272 (30 November 2009)

Both AL and DP were safe and well tolerated for the treatment of uncomplicated malaria in young HIV-infected and uninfected children.

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Open access | Assessment of the prozone effect in malaria rapid diagnostic tests

December 8, 2009 - 11:49 -- Ingeborg van Schayk
Tags: 
Author(s): 
Philippe Gillet, Marcella Mori, Marjan Van Esbroeck, Jef Van den Ende, Jan Jacobs
Reference: 
Malaria Journal 2009, 8:271 (30 November 2009)

This study confirms the prozone effect as a cause of false-negative HRP-2 RDTs in samples with hyperparasitaemia.

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