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Scientific Articles

Interaction of malaria with a common form of severe thalassemia in an Asian population

November 11, 2009 - 09:29 -- Ingeborg van Schayk
Author(s): 
A. O'Donnell, A. Premawardhena, M. Arambepola, R. Samaranayake, S. J. Allen, T. E. A. Peto, C. A. Fisher, J. Cook, P. H. Corran, Nancy F. Olivieri, and D. J. Weatherall
Reference: 
PNAS November 3, 2009 vol. 106 no. 44 18716-18721

Because the role of the environment in the course of severe thalassemia has been neglected completely and because malaria due to both Plasmodium falciparum and Plasmodium vivax has been prevalent in Sri Lanka, we carried out a pilot study of patients with HbE β thalassemia that showed high frequencies of antibodies to both parasite species and that 28.6% of the children had DNA-based evidence of current infection with P. vivax.

 

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A Unique 45-Amino-Acid Region in the Toprim Domain of Plasmodium falciparum Gyrase B Is Essential for Its Activity

November 11, 2009 - 09:03 -- Ingeborg van Schayk
Author(s): 
Ashraf Dar, Dhaneswar Prusty, Neelima Mondal, and Suman K. Dhar
Reference: 
Eukaryotic Cell 2009;8 1759-1769

This study is an attempt to understand whether the B subunit of DNA gyrase binds to DNA directly, which may be central to the stimulation of its ATPase activity essential for gyrase function. 

 

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Absence of Asymptomatic Malaria Infections in Previously High Endemic Areas of Sri Lanka

November 10, 2009 - 21:27 -- Ingeborg van Schayk
Author(s): 
S. Deepika Fernando, Rabindra R. Abeyasinghe, Gawrie N. L. Galappaththy, AND Lalani C. Rajapaksa
Reference: 
Am J Trop Med Hyg 2009;81 763-767

As the goal of malaria elimination from Sri Lanka is currently being pursued, this study was planned to determine the prevalence of asymptomatic malaria infections.

 

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Case report: Histopathology of Fatal Respiratory Distress Caused by Plasmodium vivax Malaria

November 10, 2009 - 21:20 -- Ingeborg van Schayk
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Author(s): 
Neena Valecha, Rock G. W. Pinto, Gareth D. H. Turner, Ashwani Kumar, Savio Rodrigues, Nagesh G. Dubhashi, Edmond Rodrigues, Sidhartha S. Banaulikar, Ruchi Singh, Aditya P. Dash, AND J. Kevin Baird
Reference: 
Am J Trop Med Hyg 2009;81 758-762

An otherwise healthy 20-year-old woman in Goa, India, received antibiotics after a diagnosis of upper respiratory tract infection. In this patient, vivax malaria caused a rapidly fatal respiratory distress.

 

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Short report: Malaria Diagnosis by a Polymerase Chain Reaction–Based Assay Using a Pooling Strategy

November 10, 2009 - 21:04 -- Ingeborg van Schayk
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Author(s): 
Ajay R. Bharti, Scott L. Letendre, Kailash P. Patra, Joseph M. Vinetz, AND Davey M. Smith
Reference: 
Am J Trop Med Hyg 2009;81 754-757

Pooling clinical specimens reduces the number of assays needed when screening for infectious diseases. Polymerase chain reaction (PCR)-based assays are the most sensitive tests to diagnose malaria, but its high cost limits its use.

 

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Sex Affects the Steady-State Pharmacokinetics of Primaquine but Not Doxycycline in Healthy Subjects

November 10, 2009 - 20:57 -- Ingeborg van Schayk
Author(s): 
Vu Quoc Binh, Nguyen Trong Chinh, Nguyen Xuan Thanh, Bui Tri Cuong, Nguyen Ngoc Quang, Bui Dai, Thomas Travers, AND Michael D. Edstein
Reference: 
Am J Trop Med Hyg 2009;81 747-753

The primaquine pharmacokinetic data suggest that women have increased exposure to primaquine, which may put them at increased risk for toxicity when administered the same maintenance dose as men. The similar pharmacokinetics of doxycycline between the two sexes justifies the same maintenance dose.

 

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Case report: Successful Sporozoite Challenge Model in Human Volunteers with Plasmodium vivax Strain Derived from Human Donors

November 10, 2009 - 20:48 -- Ingeborg van Schayk
Author(s): 
Sócrates Herrera, Olga Fernández, María R. Manzano, Bermans Murrain, Juana Vergara, Pedro Blanco, Ricardo Palacios, Juan D. Vélez, Judith E. Epstein, Mario Chen-Mok, Zarifah H. Reed, AND Myriam Arévalo-Herrera
Reference: 
Am J Trop Med Hyg 2009;81 740-746

In conclusion, malaria-naive volunteers can be safely and reproducibly infected with bites of 2–10 An. albimanus mosquitoes carrying P. vivax sporozoites. This challenge method is suitable for vaccine and anti-malarial drug testing.

 

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Multiple functions of human T cells generated by experimental malaria challenge

November 10, 2009 - 20:40 -- Ingeborg van Schayk
Author(s): 
Stephen M. Todryk, Michael Walther, Philip Bejon, Claire Hutchings, Fiona M. Thompson, Britta C. Urban, David W. Porter, Adrian V. S. Hill
Reference: 
European Journal of Immunology, Volume 39 Issue 11, Pages 3042 – 3051

In this study, cellular immune responses were investigated in individuals receiving Plasmodium falciparum sporozoite challenge by the natural (mosquito bite) route as part of a malaria vaccine efficacy trial. 

 

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Comparative Transcriptional and Genomic Analysis of Plasmodium falciparum Field Isolates

November 10, 2009 - 20:32 -- Ingeborg van Schayk
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Author(s): 
Mackinnon MJ, Li J, Mok S, Kortok MM, Marsh K, et al.
Reference: 
PLoS Pathog 5(10): e1000644

Mechanisms for differential regulation of gene expression may underlie much of the phenotypic variation and adaptability of malaria parasites. Here we describe transcriptional variation among culture-adapted field isolates of Plasmodium falciparum, the species responsible for most malarial disease.

 

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