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Scientific Articles

NOT Open Access | Plasmodium falciparum DDX55 is a nucleocytoplasmic protein and a 3'-5' direction-specific DNA helicase

March 9, 2020 - 14:41 -- NOT Open Access
Author(s): 
Yasmin R, Kaur I, Tuteja R
Reference: 
Protoplasma. 2020 Mar 3

Malaria is one of the major causes of mortality as well as morbidity in many tropical and subtropical countries around the world. Although artemisinin combination therapies (ACTs) are contributing to substantial decline in the worldwide malaria burden, it is becoming vulnerable by the emergence of artemisinin resistance in Plasmodium falciparum leading to clinical failure of ACTs in Southeast Asia.

Estimating Malaria Incidence through Modeling Is a Good Academic Exercise, but How Practical It Is in High-Burden Settings

March 9, 2020 - 14:39 -- Open Access
Author(s): 
Ye Y, Andrada A
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

There is global interest in frequent reliable estimates of themalaria burden, especially at the country and subnationallevels, to determine progress in malaria control efforts. Tra-ditionally, these estimates were obtained mostly from nationalhousehold surveys such as demographic and health surveysand malaria indicator surveys.

NOT Open Access | Asymptomatic Submicroscopic Plasmodium Infection Is Highly Prevalent and Is Associated with Anemia in Children Younger than 5 Years in South Kivu/Democratic Republic of Congo

March 9, 2020 - 14:37 -- NOT Open Access
Author(s): 
Lufungulo Bahati Y, Delanghe J, Bisimwa Balaluka G, Sadiki Kishabongo A, Philippe J
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

One of the most important problems in controlling malaria is the limited access to effective and accurate diagnosis of malaria parasitemia. In the Democratic Republic of Congo (DRC), malaria is one of the leading causes of morbidity and mortality. The purpose of this study was to assess the prevalence of anemia and the relationship with asymptomatic submicroscopic Plasmodium infection.

NOT Open Access | MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India

March 9, 2020 - 14:35 -- NOT Open Access
Author(s): 
van Loon W, Gai PP, Kulkarni SS, Rasalkar R, Siegert K, Wedam J, Boloor A, Baliga S, Kumar A, Jain A, Mahabala C, Shenoy D, Devi R, Gai P, Mockenhaupt FP
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%).

NOT Open Access | Capture and Detection of Plasmodium vivax Lactate Dehydrogenase in a Bead-Based Multiplex Immunoassay

March 9, 2020 - 14:30 -- NOT Open Access
Author(s): 
Rogier E, Nace D, Ljolje D, Lucchi NW, Udhayakumar V, Aidoo M
Reference: 
Am J Trop Med Hyg. 2020 Mar 2

Laboratory detection of malaria antigens has proved valuable for research and epidemiological purposes. We recently developed a bead-based multiplex antigen assay for pan-Plasmodium and Plasmodium falciparum targets. Here, we report integration of a Plasmodium vivax–specific target to this multiplex panel: P. vivax lactate dehydrogenase (PvLDH).

The activation of BAFF/APRIL system in spleen and lymph nodes of Plasmodium falciparum infected patients

March 9, 2020 - 14:28 -- Open Access
Author(s): 
Dechkhajorn W, Benjathummarak S, Glaharn S, Chaisri U, Viriyavejakul P, Maneerat Y
Reference: 
Sci Rep. 2020 Mar 2;10(1):3865

Previous studies have reported activation of the B cell-activating factor (BAFF)/a proliferation-inducing ligand (APRIL) system in T independent immunity against malaria infection. Plasmodium falciparum (P. falciparum) infected animal model is not feasible. Therefore, little is known about the occurrence of BAFF/APRIL system and changes in falciparum lymphoid tissues. This study aimed to investigate the expression of BAFF/APRIL system components in lymphoid tissues from P. falciparum infected patients.

Cas9-Mediated Gene-Editing in the Malaria Mosquito Anopheles stephensi by ReMOT Control

March 9, 2020 - 14:26 -- Open Access
Author(s): 
Macias VM, McKeand S, Chaverra-Rodriguez D, Hughes GL, Fazekas A, Pujhari S, Jasinskiene N, James AA, Rasgon JL
Reference: 
G3 (Bethesda). 2020 Mar 2. pii: g3.401133.2020

Innovative tools are essential for advancing malaria control and depend on an understanding of molecular mechanisms governing transmission of malaria parasites by Anopheles mosquitoes. CRISPR/Cas9-based gene disruption is a powerful method to uncover underlying biology of vector-pathogen interactions and can itself form the basis of mosquito control strategies. However, embryo injection methods used to genetically manipulate mosquitoes (especially Anopheles) are difficult and inefficient, particularly for non-specialist laboratories.

NOT Open Access | Early endothelial activation precedes glycocalyx degradation and microvascular dysfunction in experimentally induced Plasmodium falciparum and Plasmodium vivax infection

March 9, 2020 - 14:24 -- NOT Open Access
Author(s): 
Woodford J, Yeo TW, Piera KA, Butler K, Weinberg JB, McCarthy JS, Anstey NM, Barber BE
Reference: 
Infect Immun. 2020 Mar 2. pii: IAI.00895-19

Endothelial activation and microvascular dysfunction are key pathogenic processes in severe malaria. We evaluated the early role of these processes in experimentally induced P. falciparum and P. vivax infection.

NOT Open Access | Novel insights into Plasmodium vivax therapeutic failure: CYP2D6 activity and time of exposure to malaria modulate the risk of recurrence

March 9, 2020 - 14:21 -- NOT Open Access
Author(s): 
Silvino ACR, Kano FS, Costa MA, Fontes CJF, Soares IS, Brito CFA, Carvalho LH, Sousa TN
Reference: 
Antimicrob Agents Chemother. 2020 Mar 2. pii: AAC.02056-19

Plasmodium vivax relapse is one of the major causes of sustained global malaria transmission. Primaquine (PQ) is the only commercial drug available to prevent relapses, and its efficacy is dependent on metabolic activation by cytochrome P450 2D6 (CYP2D6). Impaired CYP2D6 function, caused by allelic polymorphisms, leads to the therapeutic failure of PQ as a radical cure for P. vivax malaria.

Comprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates

March 9, 2020 - 14:20 -- Open Access
Author(s): 
Venkatesh A, Aggarwal S, Kumar S, Rajyaguru S, Kumar V, Bankar S, Shastri J, Patankar S, Srivastava S
Reference: 
BMC Infect Dis. 2020 Mar 2;20(1):188

In recent times, Plasmodium vivax (P. vivax) has become a serious threat to public health due to its ability to cause severe infection with fatal outcomes. Its unique biology makes it resilient to control measures that are otherwise effective against P. falciparum. A deeper understanding of P. vivax biology and pathogenesis is, therefore, essential for developing the right control strategies. 

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