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Scientific Articles

Antiplasmodial activity of Cocos nucifera leaves in Plasmodium berghei-infected mice

June 8, 2020 - 15:05 -- Open Access
Author(s): 
Tayler NM, De Jesús R, Spadafora R, Coronado LM, Spadafora C
Reference: 
J Parasit Dis. 2020 Jun; 44(2):305-313

Plasmodium falciparum (P. falciparum) malaria presents serious public health problems worldwide. The parasite´s resistance to antimalarial drugs has proven to be a significant hurdle in the search for effective treatments against the disease. For this reason, the study of natural products to find new antimalarials remains a crucial step in the fight against malaria. In this study, we aimed to study the in vivo performance of the decoction of C. nucifera leaves in P. berghei-infected mice. We analyzed the effectiveness of different routes of administration and the acute toxicity of the extract.

Mass intake of hydroxychloroquine or chloroquine in the present context of the Covid-19 outbreak: Possible consequences in endemic malaria settings

June 8, 2020 - 15:04 -- Open Access
Author(s): 
Mvumbi DM
Reference: 
Medical Hypotheses, Volume 143, October 2020, 109912

In December 2019, a new viral outbreak appeared in central China, in Wuhan province. This coronavirus disease (COVID-19) spread within few months over all continents, causing numerous deaths and seriously disrupting both social and economic life.

Post-malarial anaemia in Mozambican children treated with quinine or artesunate: a retrospective observational study

June 8, 2020 - 15:02 -- Open Access
Author(s): 
Varo R, Quintó L, Bassat Q, et al.
Reference: 
Int J Infect Dis. 2020 Jun 1:S1201-9712(20)30396-9

This retrospective analysis performed in Manhiça, Southern Mozambique aimed to describe the occurrence of post-malarial anaemia (measured as a decrease of haematocrit ≥10%) and the need for blood transfusions in children with severe malaria treated with intravenous quinine or parenteral artesunate.

NOT Open Access | Oral-maxillofacial adverse events related to antimalarials

June 8, 2020 - 15:00 -- NOT Open Access
Author(s): 
Shuai Y, Wang J, Jiang H, Yu Y, Jin L
Reference: 
Oral Dis. 2020 Jun 4

Malaria is a worldwide parasitic disease, which affects millions of lives every year. Various medications are recommended by WHO for prevention and treatment of malaria. However, adverse events caused by antimalarials were frequently reported, some of which were severe and fatal.

NOT Open Access | Host-pathogen interaction in the tissue environment during Plasmodium blood-stage infection

June 8, 2020 - 14:57 -- NOT Open Access
Author(s): 
Yui K, Inoue SI
Reference: 
Parasite Immunol. 2020 Jun 4:e12763

Human malarial infection occurs after an infectious Anopheles mosquito bites. Following the initial liver‐stage infection, parasites transform into merozoites, infecting red blood cells (RBCs). Repeated RBC infection then occurs during the blood‐stage infection, while patients experience various malarial symptoms. Protective immune responses are elicited by this systemic infection, but excessive responses are sometimes harmful for hosts.

Householders' perception about sustaining the useful life of long-lasting insecticide-treated nets in Ghana

June 8, 2020 - 14:55 -- Open Access
Author(s): 
Opoku R, Amoah PA, Nyamekye KA
Reference: 
Int Health. 2020 Jun 4:ihaa019

This article explores the multifaceted perceptions among householders about the care, efficacy and disposal of long-lasting insecticide-treated nets (LLINs), especially those regarding the end of the useful life of LLINs, and their implications for malaria control.

An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons

June 8, 2020 - 14:50 -- Open Access
Author(s): 
Weedall GD, Riveron JM, Hearn J, Irving H, Kamdem C, Fouet C, White BJ, Wondji CS
Reference: 
PLoS Genet 16(6): e1008822

Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improve control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa-wide revealed evidences of a major division between southern Africa and elsewhere, associated with different population histories.

NOT Open Access | Drug Repositioning: Antimalarial Activities of GABA Analogs in Mice Infected with Plasmodium berghei

June 8, 2020 - 14:49 -- NOT Open Access
Author(s): 
Ayankunle A, Wakeel O, Kolawole O, Oyekale A, Ojurongbe O, Adeyeba O
Reference: 
Cent Nerv Syst Agents Med Chem. 2020 Jun 4

Drug repositioning is becoming popular due to the development of resistance to almost all the recommended antimalarials. Pregabalin and gabapentin are chemical analogs of gamma-aminobutyric acid (GABA) approved for the treatment of epilepsy and neuropathic pain.

Targeted repression of Plasmodium apicortin by host microRNA impairs malaria parasite growth and invasion

June 6, 2020 - 15:05 -- Open Access
Author(s): 
Chakrabarti M, Garg S, Rajagopal A, Pati S, Singh S
Reference: 
Dis Model Mech. 2020 Jun 3;13(6):dmm042820

Mature human erythrocytes contain a rich pool of microRNAs (miRNAs), which result from differentiation of the erythrocytes during the course of haematopoiesis. Recent studies have described the effect of erythrocytic miRNAs on the invasion and growth of the malaria parasite Plasmodium falciparum during the asexual blood stage of its life cycle. In this work, we have identified two erythrocytic miRNAs, miR-150-3p and miR-197-5p, that show favourable in silico hybridization with Plasmodium apicortin, a protein with putative microtubule-stabilizing properties.

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