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Scientific Articles

Brief report: HIV Protease Inhibitors, Indinavir or Nelfinavir, Augment Antimalarial Action of Artemisinin in vitro

January 14, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Lokesh C. Mishra, Amit Bhattacharya, Manish Sharma, AND Virendra K. Bhasin
Reference: 
Am J Trop Med Hyg 2010;82 148-150

Most malaria endemic regions are co-infested with HIV infection. 

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Brief report: Utility of a Point-of-Care Malaria Rapid Diagnostic Test for Excluding Malaria as the Cause of Fever among HIV-Positive Adults in Rural Rakai, Uganda

January 14, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Gertrude Nakigozi, Ronald M. Galiwango, Joseph Ouma, Joseph P. Shott, Victor Ssempijja, Ronald H. Gray, Maria J. Wawer, David Serwadda, Thomas C. Quinn, AND Steven J. Reynolds
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Am J Trop Med Hyg 2010;82 145-147

We compared results of a malaria rapid diagnostic test (Binax Now® Malaria, Binax-M, Inverness Medical Innovations, Inc., Waltham, MA) performed at rural mobile clinics in Uganda by clinicians evaluating febrile adult HIV patients to thick smear evaluated at a central laboratory by trained microscopists.

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A Randomized Trial of Artesunate Mefloquine versus Artemether Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Senegalese Children

January 14, 2010 - 10:55 -- Ingeborg van Schayk
Author(s): 
Babacar Faye, Jean Louis Ndiaye, Roger Tine, Khadim Sylla, Ali Gueye, Aminata Colle Lô, AND Oumar Gaye
Reference: 
Am J Trop Med Hyg 2010;82 140-144

An open randomized clinical trial study was carried out to compare efficacy and tolerability of artesunate mefloquine 25 mg/kg body weight (Artequin paediatric) versus artemether lumefantrine (Coartem) in the treatment of uncomplicated Plasmodium falciparum malaria in children.

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Brief report: Elevated Levels of Vascular Endothelial Growth Factor (VEGF) and Soluble Vascular Endothelial Growth Factor Receptor (VEGFR)-2 in Human Malaria

January 14, 2010 - 10:48 -- Ingeborg van Schayk
Author(s): 
Takahisa Furuta, Mikio Kimura, AND Naohiro Watanabe
Reference: 
Am J Trop Med Hyg 2010;82 136-139

This is the first report to suggest that the interaction of VEGF and sVEGFR-2 is involved in the host immune response to malarial infection and that malarial parasites induce VEGF secretion from human mast cells.

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The Effect of Malaria and Intestinal Helminth Coinfection on Birth Outcomes in Kumasi, Ghana

January 14, 2010 - 10:31 -- Ingeborg van Schayk
Author(s): 
Nelly J. Yatich, Pauline E. Jolly, Ellen Funkhouser, Tsiri Agbenyega, Julian C. Rayner, John E. Ehiri, Archer Turpin, Jonathan K. Stiles, William O. Ellis, Yi Jiang, AND Jonathan H. Williams
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Am J Trop Med Hyg 2010;82 28-34

This study was conducted to investigate the effect of Plasmodium falciparum and intestinal helminth coinfection on maternal anemia and birth outcomes. 

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Open Access | Costs of insensitive acetylcholinesterase insecticide resistance for the malaria vector Anopheles gambiae homozygous for the G119S mutation

January 13, 2010 - 13:31 -- Ingeborg van Schayk
Author(s): 
Luc Djogbenou, Valerie Noel, Philip Agnew
Reference: 
Malaria Journal 2010, 9:12 (13 January 2010)

The paper provides valuable information on fitness costs to the homozygote susceptible and resistant strains. The authors show that the largest impact is on pupal mortality, while the costs of earlier pupation and smaller adult size are less clear.

Open Access | Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies

January 13, 2010 - 13:28 -- Ingeborg van Schayk
Author(s): 
Ali Salanti, Mafalda Resende, Sisse B Ditlev, Vera V Pinto, Madeleine Dahlback, Gorm Andersen, Tom Manczak, Thor G Theander, Morten A Nielsen
Reference: 
Malaria Journal 2010, 9:11 (11 January 2010)

The paper provides additional data on the characterization of CSA-binding PfEMP1 domains, implicated in placental malaria, including practical concerns about how to develop an anti-PAM vaccine.

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Open Access | Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report

January 13, 2010 - 13:23 -- Ingeborg van Schayk
Author(s): 
Janet Cox-Singh, Jessie Hiu, Sebastian B Lucas, Paul C Divis, Mohammad Zulkarnaen, Patricia Chandran, Kum T Wong, Patricia Adem, Sherif R Zaki, Balbir Singh, Sanjeev Krishna
Reference: 
Malaria Journal 2010, 9:10 (11 January 2010)

A case report of a fatal case of malaria knowlesi in a formerly healthy 40-year old male, ten days after spending time in the jungle of North Borneo.

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Open Access | Molecular markers of resistance to sulphadoxine-pyrimethamine one year after implementation of intermittent preventive treatment of malaria in infants in Mali

January 13, 2010 - 13:20 -- Ingeborg van Schayk
Author(s): 
Alassane Dicko, Issaka Sagara, Abdoulaye A Djimde, Sidy O Toure, Mariam Traore, Souleymane Dama, Abdoulbaki I Diallo, Amadou Barry, Mohamed Dicko, Oumar M Coulibaly, Christophe Rogier, Alexandra de Sousa, Ogobara K Doumbo
Reference: 
Malaria Journal 2010, 9:9 (10 January 2010)

A paper that addresses the issue of possible selection of drug resistant parasites in the context of Intermittent Preventive Treatment in infants. Importantly, this study evaluates the impact of the intervention at community level, in a context of a large scale implementation.

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Open Access | Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance

January 13, 2010 - 13:15 -- Ingeborg van Schayk
Author(s): 
Jutta Marfurt, Thomas A Smith, Ian M Hastings, Ivo Muller, Albert Sie, Olive Oa, Moses Baisor, John C Reeder, Hans-Peter Beck, Blaise Genton
Reference: 
Malaria Journal 2010, 9:8 (7 January 2010)

Interesting paper aiming at investigating the role and applicability of the molecular drug resistance profiles in community samples in Papua New Guinea.

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