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Scientific Articles

Open Access | Evaluation of PermaNet 3.0 a deltamethrin-PBO combination net against Anopheles gambiae and pyrethroid resistant Culex quinquefasciatus mosquitoes: an experimental hut trial in Tanzania

January 19, 2010 - 16:04 -- Ingeborg van Schayk
Author(s): 
Patrick Tungu, Stephen Magesa, Caroline Maxwell, Robert Malima, Dennis Masue, Wema Sudi, Joseph Myamba, Olivier Pigeon, Mark Rowland
Reference: 
Malaria Journal 2010, 9:21 (19 January 2010)

Interesting study that highlights the importance of developing effective control tools that can be utilized in resistance management programmes. Although the results of the paper do not provide overwhelming support for the deltamethrin and piperonyl butoxide combination bednet, it is an important negative result.

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Open Access | Commentary: Plasmodium knowlesi malaria in Vietnam: some clarifications

January 19, 2010 - 15:59 -- Ingeborg van Schayk
Author(s): 
Peter Van den Eede, Indra Vythilingam, Thang Ngo Duc, Hong Nguyen Van, Le Xuan Hung, Umberto D'Alessandro, Annette Erhart
Reference: 
Malaria Journal 2010, 9:20 (18 January 2010)

Response by the authors to a recent commentary published in Malaria Journal.

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Open Access | Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda

January 19, 2010 - 15:54 -- Ingeborg van Schayk
Author(s): 
Vinay Gupta, Grant Dorsey, Alan E Hubbard, Philip J Rosenthal, Bryan Greenhouse
Reference: 
Malaria Journal 2010, 9:19 (15 January 2010)

This paper presents strong evidence that capillary electrophoresis (CE) is better than gel electrophoresis in discriminating recrudescence from reinfection. This has important implications for drug development.

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Open Access | Intermittent screening and treatment versus intermittent preventive treatment of malaria in pregnancy: user acceptability

January 19, 2010 - 15:45 -- Ingeborg van Schayk
Author(s): 
Lucy A Smith, Caroline Jones, Rose O Adjei, Gifty D Antwi, Nana A Afrah, Brian Greenwood, Daniel Chandramohan, Harry Tagbor, Jayne Webster
Reference: 
Malaria Journal 2010, 9:18 (14 January 2010)

Due to very high and increasing resistance of malaria parasites to SP in Africa there is a need for alternative methods to protect pregnant women from the effects of malaria in pregnancy. This study describes pregnant women’s acceptability of such an alternative method based on intermittent RDT screening followed by treatment of those found positive. 

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Open Access | Improved methods for magnetic purification of malaria parasites and haemozoin

January 19, 2010 - 15:40 -- Ingeborg van Schayk
Author(s): 
Charles C Kim, Emily B Wilson, Joseph L DeRisi
Reference: 
Malaria Journal 2010, 9:17 (14 January 2010)

How to construct a cheap separation system for isolating haemozoin and infected red blood cells from malaria infected blood cultures using a magnet. The study is the first report of the effect of magnet strength and configuration on the efficiency of isolation of both haemozoin and iRBCs.

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Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity

January 14, 2010 - 18:23 -- Kabogo Ndegwa
Author(s): 
V. Tomar, G. Bhattacharjee, Kamaluddin, S. Rajakumar, Kumkum Srivastava, S.K. Puri
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 2, February 2010, Pages 745-751

A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3′-aminochalcone or 4′-aminochalcones and 9-chloroacridine.

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Synthesis and antimalarial evaluation of 1, 3, 5-trisubstituted pyrazolines

January 14, 2010 - 18:19 -- Kabogo Ndegwa
Author(s): 
Badri Narayan Acharyaa, Deepika Saraswata, Mugdha Tiwaria, Asish Kumar Shrivastavaa, Ramarao Ghorpadea, Saroj Bapnab and Mahabir Parshad Kaushika
Reference: 
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 430-438

A series of 1,3,5-trisubstituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium falciparum.

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Original quinazoline derivatives displaying antiplasmodial properties

January 14, 2010 - 18:13 -- Kabogo Ndegwa
Author(s): 
Youssef Kabria, Nadine Azasb, Aurélien Dumètreb, Sébastien Hutterb, Michèle Lagetb, Pierre Verhaeghea, Armand Gellisa and Patrice Vanellea
Reference: 
European Journal of Medicinal Chemistry Volume 45, Issue 2, February 2010, Pages 616-622

The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).

Investigating Alternative Acidic Proteases for H/D Exchange Coupled to Mass Spectrometry: Plasmepsin 2 but not Plasmepsin 4 Is Active Under Quenching Conditions

January 14, 2010 - 18:12 -- Kabogo Ndegwa
Author(s): 
Julien Marcouxa, b, Eric Thierrya, Corinne Vivèsb, Luca Signora, Franck Fieschib and Eric Foresta
Reference: 
Journal of the American Society for Mass Spectrometry, Volume 21, Issue 1, January 2010, Pages 76-79

Structural studies of proteins by hydrogen/deuterium exchange coupled to mass spectrometry (DXMS) require the use of proteases working at acidic pH and low temperatures.

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In vivo study of human Plasmodium knowlesi in Macaca fascicularis

January 14, 2010 - 18:04 -- Kabogo Ndegwa
Author(s): 
F. Anderios, A. NoorRain, I. Vythilingam
Reference: 
Experimental Parasitology, Volume 124, Issue 2, February 2010, Pages 181-189

In this study Macaca fascicularis was used as a model to understand the host response to P. knowlesi using parasitological and haematological parameters.

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