Interesting study that highlights the importance of developing effective control tools that can be utilized in resistance management programmes. Although the results of the paper do not provide overwhelming support for the deltamethrin and piperonyl butoxide combination bednet, it is an important negative result.
Response by the authors to a recent commentary published in Malaria Journal.
This paper presents strong evidence that capillary electrophoresis (CE) is better than gel electrophoresis in discriminating recrudescence from reinfection. This has important implications for drug development.
Due to very high and increasing resistance of malaria parasites to SP in Africa there is a need for alternative methods to protect pregnant women from the effects of malaria in pregnancy. This study describes pregnant women’s acceptability of such an alternative method based on intermittent RDT screening followed by treatment of those found positive.
How to construct a cheap separation system for isolating haemozoin and infected red blood cells from malaria infected blood cultures using a magnet. The study is the first report of the effect of magnet strength and configuration on the efficiency of isolation of both haemozoin and iRBCs.
A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic aromatic substitution reaction between various 3′-aminochalcone or 4′-aminochalcones and 9-chloroacridine.
A series of 1,3,5-trisubstituted pyrazolines were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive (MRC-02) as well as chloroquine resistant (RKL9) strains of Plasmodium falciparum.
The multistep synthesis of new quinazoline-derived molecules and their in vitro antiplasmodial evaluation on the W2 chloroquino-resistant Plasmodium falciparum strain is described herein. These molecules have also been studied concerning their in vitro cytotoxicity toward two human cell lines (K652 and HepG2) in order to calculate their respective selectivity indexes (S.I.).
Structural studies of proteins by hydrogen/deuterium exchange coupled to mass spectrometry (DXMS) require the use of proteases working at acidic pH and low temperatures.
In this study Macaca fascicularis was used as a model to understand the host response to P. knowlesi using parasitological and haematological parameters.