A study in mice suggests that CSP-based protein-peptide conjugates could be useful vaccines against malaria infection. Further details on the research, next steps and licensing status are discussed in the article.
The malaria parasite harbours an indispensable plastid known as the ‘apicoplast’. The apicoplast’s exact role remains uncertain, but it houses components involved in fatty acid, isoprenoid and haem biosyntheses.
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This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis.
A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity.
Phytochemical investigation of CHCl3 extract of the Gomphostemma niveum leaves led to the isolation of two new diterpene, compound 1 and 2. Their structures were elucidated by spectroscopic procedures and single crystal XRD.
Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time.
Although whole-parasite vaccine strategies for malaria infection have regained attention, their immunological mechanisms of action remain unclear.
The “built-in” adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a “built-in” adjuvant.