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Scientific Articles

Plasmodium falciparum circumsporozoite protein (CSP)

January 28, 2010 - 12:31 -- Kabogo Ndegwa
Author(s): 
Published online
Reference: 
SciBX: Science-Business eXchange, Volume 3 / Issue 3, January 21 2010

A study in mice suggests that CSP-based protein-peptide conjugates could be useful vaccines against malaria infection. Further details on the research, next steps and licensing status are discussed in the article.

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The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

January 28, 2010 - 12:18 -- Kabogo Ndegwa
Author(s): 
Liting Lim, Marc Linka, Kylie A. Mullin, Andreas P.M. Weber and Geoffrey I. McFadden
Reference: 
FEBS Letters, Volume 584, Issue 3, 5 February 2010, Pages 549-554

The malaria parasite harbours an indispensable plastid known as the ‘apicoplast’. The apicoplast’s exact role remains uncertain, but it houses components involved in fatty acid, isoprenoid and haem biosyntheses.

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Letter: Atorvastatin as a Potential Antimalarial Drug: In Vitro Synergy in Combinational Therapy with Dihydroartemisinin

January 28, 2010 - 12:17 -- Kabogo Ndegwa
Author(s): 
Hélène Savini, Jean Baptiste Souraud, Sébastien Briolant, Eric Baret, Rémy Amalvict, Christophe Rogier, and Bruno Pradines
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 966-967, Vol. 54, No. 2

No abstract available

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Clinical Therapeutics: Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects{triangledown}

January 28, 2010 - 12:14 -- Kabogo Ndegwa
Author(s): 
Peter E. Nasveld, Michael D. Edstein, Mark Reid, Leonard Brennan, Ivor E. Harris, Scott J. Kitchener, Peter A. Leggat, Philip Pickford, Caron Kerr, Colin Ohrt, William Prescott, and the Tafenoquine Study Team
Reference: 
Antimicrobial Agents and Chemotherapy, February 2010, p. 792-798, Vol. 54, No. 2

This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis.

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones

January 28, 2010 - 12:12 -- Kabogo Ndegwa
Author(s): 
Renate H. Hans, Eric M. Guantai, Carmen Lategan, Peter J. Smith, Baojie Wan, Scott G. Franzblau, Jiri Gut, Philip J. Rosenthal and Kelly Chibal
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 942-944

A series of acetylenic chalcones were evaluated for antimalarial and antitubercular activity.

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Gomphostenins: Two new antimalarial compounds from the leaves of Gomphostemma niveum

January 28, 2010 - 12:09 -- Kabogo Ndegwa
Author(s): 
Manisha Sathe and M.P. Kaushik
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 1312-1314

Phytochemical investigation of CHCl3 extract of the Gomphostemma niveum leaves led to the isolation of two new diterpene, compound 1 and 2. Their structures were elucidated by spectroscopic procedures and single crystal XRD.

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Synthesis and evaluation of phenylequine for antimalarial activity in vitro and in vivo

January 28, 2010 - 10:14 -- Kabogo Ndegwa
Author(s): 
Margaret A.L. Blackie, Vanessa Yardley and Kelly Chibale
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 3, 1 February 2010, Pages 1078-1080

Synthesis of the potent antiplasmodial 4-aminoquinoline, phenylequine (PQ), is reported for the first time.

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Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9

January 28, 2010 - 10:12 -- Kabogo Ndegwa
Author(s): 
Cevayir Coban, Yoshikatsu Igari, Shizuo Akira
Reference: 
Cell Host & Microbe, Volume 7, Issue 1, 21 January 2010, Pages 50-61

Although whole-parasite vaccine strategies for malaria infection have regained attention, their immunological mechanisms of action remain unclear.

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Preview: Hemozoin: Malaria's “Built-In” Adjuvant and TLR9 Agonist

January 28, 2010 - 10:11 -- Kabogo Ndegwa
Author(s): 
Hermann Wagner
Reference: 
Cell Host & Microbe, Volume 7, Issue 1, 21 January 2010, Pages 5-6

The “built-in” adjuvant in a whole-microbe vaccine potentially triggers protective immunity. Coban et al. now demonstrate that crude blood stage extract of the malaria parasite Plasmodium falciparum drives parasite-specific immune responses via Hemozoin, a byproduct of heme detoxification, functioning as a TLR9 agonist and, therefore, as a “built-in” adjuvant.

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Open Access | Pre-elimination of malaria on the island of Principe

January 27, 2010 - 10:59 -- Ingeborg van Schayk
Author(s): 
Pei-Wen Lee, Chia-Tai Liu, Herodes Sacramento Rampao, Virgilio E do Rosario, Men-Fang Shaio
Reference: 
Malaria Journal 2010, 9:26 (20 January 2010)

The effective measures of the combination of four major control methods have produced a rapid decline in malaria morbidity and mortality on the island of Principe.

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