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Scientific Articles

Review: Iron delocalisation in the pathogenesis of malarial anaemia

March 5, 2010 - 12:06 -- Kabogo Ndegwa
Author(s): 
Chidi V. Nweneka, Conor P. Doherty, Sharon Cox, Andrew Prentice
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 175-184

In this review, we attempt to build a composite picture of the pathophysiology of malarial anaemia using evidence from experimental, human and animal studies. 

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Behavioral heterogeneity of Anopheles darlingi (Diptera: Culicidae) and malaria transmission dynamics along the Maroni River, Suriname, French Guiana

March 5, 2010 - 11:59 -- Kabogo Ndegwa
Author(s): 
H. Hiwat, J. Issaly, P. Gaborit, A. Somai, A. Samjhawan, P. Sardjoe, T. Soekhoe, R. Girod
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 207-213

The border area between Suriname and French Guiana is considered the most affected malaria area in South America. A one-year cooperative malaria vector study was performed by the two countries, between March 2004 and February 2005, in four villages.

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Island fever: the historical determinants of malaria in the Andaman Islands

March 5, 2010 - 11:56 -- Kabogo Ndegwa
Author(s): 
G. Dennis Shanks, David J. Bradley
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 185-190

The history of malaria control in the Andaman Islands Penal Colony is a cautionary tale that well-meaning and well-funded efforts can fail spectacularly if local epidemiological reality is not well understood.

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Case Report: A mixed malaria infection: is Plasmodium vivax good for you?

March 5, 2010 - 11:44 -- Kabogo Ndegwa
Author(s): 
J. Whitehorn, C. Coltart, D. Manser, T. Doherty
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 240-241

describe a case of mixed malaria infection in a returning traveller

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Short Communication: Performance of a prototype malaria rapid diagnostic test versus thick film microscopy among HIV-positive subjects in rural Rakai, Uganda

March 5, 2010 - 11:27 -- Kabogo Ndegwa
Author(s): 
Lisa A. Mills, Joseph Kagaayi, Joseph P. Shott, Kevin Newell, John Baptist Bwanika, Victor Ssempijja, Simon Aluma, Thomas C. Quinn, Steven J. Reynolds, Ronald H. Gray
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 104, Issue 3, March 2010, Pages 237-239

In this study, we report the performance of a prototype malaria rapid diagnostic test, Malaria F-test (MFT), compared with thick blood films from HIV-positive Ugandans undergoing malaria testing.

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Malaria prevention behaviour and risk awareness in French adult travellers

March 5, 2010 - 11:16 -- Kabogo Ndegwa
Author(s): 
Thierry Pistone, Khaled Ezzedine, Anne-Françoise Gaudin, Serge Hercberg, Gaëlle Nachbaur, Denis Malvy
Reference: 
Travel Medicine and Infectious Disease, Volume 8, Issue 1, January 2010, Pages 13-21

The objective of this study was to assess malaria protection measures in European travellers as a function of the risk of infection with malaria. 

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Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride

March 5, 2010 - 11:14 -- Kabogo Ndegwa
Author(s): 
C. Okwelogu, B. Clark, M. de Matas, D. Ifudu, C. Igwilo, B. Silva, P. York
Reference: 
International Journal of Pharmaceutics, Volume 387, Issues 1-2, 15 March 2010, Pages 19-25

It was therefore concluded that a stable, versatile paediatric preparation of the two drugs could be prepared by blending pre-formulated granules containing the individual constituents rather than producing a combined granule comprising intimate mixtures of the two agents.

Short Communication: Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia

March 5, 2010 - 11:07 -- Kabogo Ndegwa
Author(s): 
Judy Natalia Jiménez, Georges Snounou, Frank Letourneur, Laurent Rénia, Iván D. Vélez, Carlos E. Muskus
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 67-70

Assessment of the genetic diversity of Plasmodium falciparum in 110 Colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the Andes shared the same Pfmsp1 block 2 MAD20-type allelic variant, despite showing high diversity for other genetical markers.

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Short communication: Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

March 5, 2010 - 11:00 -- Kabogo Ndegwa
Author(s): 
Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 63-66

The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area.

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Spatial distribution and r-DNA second internal transcribed spacer characterization of Anopheles dirus (Diptera: Culicidae) complex species in north-east India

March 5, 2010 - 10:08 -- Kabogo Ndegwa
Author(s): 
Anil Prakash, D.K. Sarma, D.R. Bhattacharyya, P.K. Mohapatra, K. Bhattacharjee, K. Das, J. Mahanta
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 49-54

The identity and distribution of the prevalent member species of the Anopheles dirus complex mosquitoes in the north-eastern region of India was investigated in a cross-sectional study.

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