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Scientific Articles

The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum

March 9, 2010 - 12:11 -- Ingeborg van Schayk
Author(s): 
Jun Miao, Jinfang Li, Qi Fan, Xiaolian Li, Xinyi Li, and Liwang Cui
Reference: 
J. Cell Sci. published 2 March 2010, 10.1242/jcs.059824

In this study we determined the function of PfPuf2, a member of the Puf family of translational repressors, in gametocytogenesis of Plasmodium falciparum.

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization

March 9, 2010 - 12:02 -- Ingeborg van Schayk
Author(s): 
Babak Razani, Chu Feng and Clay F. Semenkovich
Reference: 
J. Lipid Res., doi:10.1194/jlr.M003681

ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. The anti-malarial drug chloroquine activates ATM signaling and improves metabolic phenotypes in mice.

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Role of cis-regulatory elements on the ring-specific hrp3 promoter in the human parasite Plasmodium falciparum

March 8, 2010 - 12:17 -- Ingeborg van Schayk
Author(s): 
Anusha M. Gopalakrishnan and Carlos López-Estraño
Reference: 
Parasitology Research, Online First

Together, our results indicate the presence of multiple mechanisms of gene regulation in the parasite.

Identification and characterization of autoantibody-producing B220low B (B-1) cells appearing in malarial infection

March 7, 2010 - 13:35 -- Ingeborg van Schayk
Author(s): 
Yasuhiro Kanda, Hiroki Kawamura, Hiroaki Matsumoto, Takahiro Kobayashi, Toshihiko Kawamura, Toru Abo
Reference: 
Cellular Immunology, In Press, Accepted Manuscript, Available online 25 February 2010

These results suggested that malaria immune responses were not mediated by conventional T and B cells but resembled the responses during autoimmune diseases.

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Open Access | Attracting, trapping and killing disease-transmitting mosquitoes using odor-baited stations -The Ifakara Odor-Baited Stations

March 7, 2010 - 13:25 -- Ingeborg van Schayk
Author(s): 
Fredros O Okumu, Edith P Madumla, Alex N John, Dickson W Lwetoijera and Robert D Sumaye
Reference: 
Parasites & Vectors 2010, 3:12

The Ifakara OBS is efficacious against disease-carrying mosquitoes including the malaria vector, An. arabiensis and Culicine vectors of filarial worms and arboviruses. 

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Open Access | Community-wide benefits of targeted indoor residual spray for malaria control in the Western Kenya Highland

March 7, 2010 - 13:09 -- Ingeborg van Schayk
Author(s): 
Guofa Zhou, Andrew K Githeko, Noboru Minakawa, Guiyun Yan
Reference: 
Malaria Journal 2010, 9:67 (3 March 2010)

Where malaria transmission is concentrated around focal points, however, targeted IRS may pose a feasible alternative to mass spraying. Here, the impact of targeted IRS was assessed in the highlands of western Kenya.

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Open Access | Transmission blocking activity of a standardized neem (Azadirachta indica) seed extract on the rodent malaria parasite Plasmodium berghei in its vector Anopheles stephensi

March 7, 2010 - 13:02 -- Ingeborg van Schayk
Author(s): 
Leonardo Lucantoni, Rakiswende S Yerbanga, Giulio Lupidi, Luciano Pasqualini, Fulvio Esposito, Annette Habluetzel
Reference: 
Malaria Journal 2010, 9:66 (2 March 2010)

These results and evidence of anti-plasmodial activity of neem products accumulated over the last years encourage to convey neem compounds into the drug discovery & development pipeline and to evaluate their potential for the design of novel or improved transmission-blocking remedies.

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Open Access | Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

March 7, 2010 - 12:56 -- Ingeborg van Schayk
Author(s): 
Kiattawee Choowongkomon, Sasikrit Theppabutr, Napat Songtawee, Nicholas PJ Day, Nicholas J White, Charles J Woodrow, Mallika Imwong
Reference: 
Malaria Journal 2010, 9:65 (2 March 2010)

Here the interactions between DHFR inhibitors and modelled structures of the DHFR enzymes of Plasmodium malariae (PmDHFR) and Plasmodium ovale (PoDHFR) are described, along with an investigation of the effect of recently reported mutations within PmDHFR.

Open Access | Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation

March 7, 2010 - 12:45 -- Ingeborg van Schayk
Author(s): 
Esther Bettiol, Daniel Carapau, Cristina Galan-Rodriguez, Carlos Ocana-Morgner and Ana Rodriguez
Reference: 
Malaria Journal 2010, 9:64 (1 March 2010)

These results help to explain why immune functions are altered during malaria, and provide a system for the identification of a parasite-derived broad inhibitor of TLR-mediated signaling pathways.

Open Access | Case report: Congenital Plasmodium vivax malaria mimicking neonatal sepsis: a case report

March 7, 2010 - 12:34 -- Ingeborg van Schayk
Author(s): 
Veronica Del Punta, Maurizio Gulletta, Alberto Matteelli, Vania Spinoni, Antonio Regazzoli, Francesco Castelli
Reference: 
Malaria Journal 2010, 9:63 (1 March 2010)

Although malaria in pregnancy can cause very significant neonatal morbidity, congenital malaria is a very rare condition in both endemic and non-endemic areas.

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