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Scientific Articles

Open Access | Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

February 17, 2010 - 20:15 -- Ingeborg van Schayk
Author(s): 
Erin Milner, William McCalmont, Geoffrey Dow et al.
Reference: 
Malaria Journal 2010, 9:51 (11 February 2010)

Description of the in vitro screening of a library of mefloquine analogues, to find lead compounds that retain the favourable characteristics of mefloquine whilst minimizing the unfavourable ones of high BBB permeability. 

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Open Access | Retail sector distribution chains for malaria treatment in the developing world: a review of the literature

February 17, 2010 - 20:07 -- Ingeborg van Schayk
Author(s): 
Edith Patouillard, Kara G Hanson, Catherine A Goodman
Reference: 
Malaria Journal 2010, 9:50 (11 February 2010)

This review calls for rigorous distribution chain analysis, notably on the factors that influence ACT availability and prices in order to contribute to efforts towards improved access to effective malaria treatment.

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Open Access : Methodology: Flow cytometry for the evaluation of anti-plasmodial activity of drugs on Plasmodium falciparum gametocytes

February 17, 2010 - 19:52 -- Ingeborg van Schayk
Author(s): 
Severine Chevalley, Agnes Coste, Alexandrine Lopez, Bernard Pipy, Alexis Valentin
Reference: 
Malaria Journal 2010, 9:49 (11 February 2010)

In the current study, flow cytometry has been used to study the effect of established anti-malarial drugs against sexual stages obtained from W2 strain of Plasmodium falciparum.

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Editorial: King Tutankhamun, Modern Medical Science, and the Expanding Boundaries of Historical Inquiry

February 17, 2010 - 08:56 -- Ingeborg van Schayk
Author(s): 
Howard Markel
Reference: 
JAMA. 2010;303(7):667-668

Indeed, this finding constitutes the oldest genetic proof of malaria in well-dated mummies.

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Ancestry and Pathology in King Tutankhamun's Family

February 17, 2010 - 08:48 -- Ingeborg van Schayk
Author(s): 
Zahi Hawass, Yehia Z. Gad, Carsten M. Pusch et al.
Reference: 
JAMA, February 17, 2010; 303: 638 - 647

These results suggest avascular bone necrosis in conjunction with the malarial infection as the most likely cause of death in Tutankhamun. Walking impairment and malarial disease sustained by Tutankhamun is supported by the discovery of canes and an afterlife pharmacy in his tomb.

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Open Access | Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania

February 16, 2010 - 14:02 -- Ingeborg van Schayk
Author(s): 
Abdunoor M Kabanywanyi, Christian Lengeler, Prudensiana Kasim, Said King'eng'ena, Raymond Schlienger, Nathan Mulure, Blaise Genton
Reference: 
Malaria Journal 2010, 9:48 (11 February 2010)

Adherence to the dosing regimen and timing of AL administration was very good.

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Open Access | The influence of the Gilgel-Gibe hydroelectric dam in Ethiopia on caregivers' knowledge, perceptions and health-seeking behaviour towards childhood malaria

February 16, 2010 - 13:56 -- Ingeborg van Schayk
Author(s): 
Delenasaw Yewhalaw, Wondwossen Kassahun, Kifle Woldemichael, Kora Tushune, Moranker Sudaker, Daniel Kaba, Luc Duchateau, Wim Van Bortel, Niko Speybroeck
Reference: 
Malaria Journal 2010, 9:47 (11 February 2010)

Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs of the disease.

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Open Access : Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii

February 16, 2010 - 13:33 -- Ingeborg van Schayk
Author(s): 
Irosoki Eslava, Gilberto Payares, Beatriz M Pernia, Anthony A Holder, Lilian M Spencer
Reference: 
Malaria Journal 2010, 9:46 (10 February 2010)

These results suggest that a combination of protective antibodies with either the same or different isotypes can produce either an additive or a suppressive effect in passive immunization. This phenomenon may be important in better understanding immunity in this experimental mouse model of malaria.

Is It Time to Change Guidelines for Iron Supplementation in Malarial Areas?

February 16, 2010 - 12:58 -- Ingeborg van Schayk
Author(s): 
Parminder S. Suchdev, Ira L. Leeds, Deborah A. McFarland, and Rafael Flores
Reference: 
J. Nutr. published 10 February 2010, 10.3945/jn.109.118638

 No abstract available

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Open Access | A Plasmodium falciparum Strain Expressing GFP throughout the Parasite's Life-Cycle

February 16, 2010 - 11:11 -- Ingeborg van Schayk
Author(s): 
Arthur M. Talman, Andrew M. Blagborough, Robert E. Sinden
Reference: 
PLoS ONE 5(2): e9156

The development of 3D7HT-GFP will permit a deeper understanding of the biology of parasite-host vector interactions, and facilitate the development of high-throughput malaria transmission assays and thus aid development of new intervention strategies against both parasite and mosquito.

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