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Scientific Articles

Microbiology and Virology: An α-amylase is a novel receptor for Bacillus thuringiensis ssp. israelensis Cry4Ba and Cry11Aa toxins in the malaria vector mosquito Anopheles albimanus (Diptera: Culicidae)

March 11, 2010 - 10:15 -- Kabogo Ndegwa
Author(s): 
Maria Teresa Fernandez-Luna, Humberto Lanz-Mendoza, Sarjeet S. Gill, Alejandra Bravo, Mario Soberon, Juan Miranda-Rios
Reference: 
Environmental Microbiology, Volume 12, Issue 3, Date: March 2010, Pages: 746-757

Previous work showed that Bti is highly toxic to Anopheles albimanus, the main vector for transmission of malaria in Mexico. In this work, we analysed the toxicity of isolated Cry proteins of Bti and identified an An. albimanus midgut protein as a putative Cry4Ba and Cry11Aa receptor molecule.

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Predictive Factors of Imported Malaria in 272 Febrile Returning Travelers Seen as Outpatients

March 10, 2010 - 15:39 -- Ingeborg van Schayk
Author(s): 
Séverine Ansart, Lucia Perez, Marc Thellier, Martin Danis, François Bricaire, Eric Caumes
Reference: 
Journal of Travel Medicine Volume 17 Issue 2, Pages 124 - 129

We conducted a prospective study to evaluate the aetiologies of fever in returning travelers and to identify the clinical and laboratory factors predictive of malaria in travelers returning from tropical areas with fever.

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Quartan malaria-associated childhood nephrotic syndrome: now a rare clinical entity in malaria endemic Nigeria

March 10, 2010 - 15:28 -- Ingeborg van Schayk
Author(s): 
Wasiu A. Olowu, Kayode A. Adelusola, Olufemi Adefehinti, and Tajudeen G. Oyetunji
Reference: 
Nephrol. Dial. Transplant. 2010; 25:794-801

The study determined (i) whether or not quartan malaria nephropathy (QMN) is still a major cause of childhood nephrotic syndrome (CNS) in Nigeria, (ii) secondary causes other than QMN and their associated glomerular pathology and (iii) renal and patient outcome.

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High prevalence of sulfadoxine/pyrimethamine-resistant alleles of Plasmodium falciparum isolates in pregnant women at the time of introduction of intermittent preventive treatment with sulfadoxine/pyrimethamine in Gabon

March 10, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Tanguy de Dieu Tchantchou, and Maryvonne Kombila
Reference: 
J. Antimicrob. Chemother. 2010 65: 438-441

These findings underline the need for a regular assessment of the relationship between the presence of resistant isolates and in vitro/in vivo IPTp/SP efficacy, and evaluation of an alternative drug.

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Open Access | Review: In vitro selection of Plasmodium falciparum drug-resistant parasite lines

March 10, 2010 - 13:43 -- Ingeborg van Schayk
Author(s): 
Alexis Nzila and Leah Mwai
Reference: 
J. Antimicrob. Chemother. 2010 65: 390-398; doi:10.1093/jac/dkp449

In this review, we discuss the key parameters that impact on the efficiency of the in vitro selection of resistance, and propose strategies to improve and streamline this process.

Open Access | Assessing the future threat from vivax malaria in the United Kingdom using two markedly different modelling approaches

March 9, 2010 - 14:10 -- Ingeborg van Schayk
Author(s): 
Steven W Lindsay, David G Hole, Robert A Hutchinson, Shane A Richards, Steven G Willis
Reference: 
Malaria Journal 2010, 9:70 (5 March 2010)

Although the future climate in the UK is favourable for the transmission of vivax malaria, the future risk of locally transmitted malaria is considered low because of low vector biting rates and the low probability of vectors feeding on a malaria-infected person.

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Open Access | Distribution of the main malaria vectors in Kenya

March 9, 2010 - 14:05 -- Ingeborg van Schayk
Author(s): 
Robi M Okara, Marianne E Sinka, Noboru Minakawa, Charles M Mbogo, Simon I Hay, Robert W Snow
Reference: 
Malaria Journal 2010, 9:69 (4 March 2010)

The data collated here are published alongside this paper where it may help guide future sampling location decisions, help with the planning of vector control suites nationally and encourage broader research inquiry into vector species niche modelling.

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Open Access | Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates

March 9, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Sabelo V Dlamini, Khalid Beshir, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:68 (3 March 2010)

Anti-malarial policy changes in neighbouring countries may have had an impact on the prevalence of molecular markers of anti-malarial resistance in Swaziland, and it is hoped that this new information will add to understanding of the regional anti-malarial resistance map.

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Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae

March 9, 2010 - 13:50 -- Ingeborg van Schayk
Author(s): 
Guirong Wang, Allison F. Carey, John R. Carlson, and Laurence J. Zwiebel
Reference: 
PNAS March 2, 2010 vol. 107 no. 9 4418-4423

his study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.

Systematic review: Low-quality evidence that atovaquone-proguanil and doxycycline are better tolerated prophylactic antimalarial regimens in travellers than mefloquine

March 9, 2010 - 13:03 -- Ingeborg van Schayk
Author(s): 
Michael Hawkes
Reference: 
Evid. Based Nurs. 2010; 13:19-20

he scope of this review is the prevention of Plasmodium falciparum, which is the malaria species that causes the overwhelming majority of severe disease and death, and which in many areas of the world is frequently resistant to the classical antimalarial agent chloroquine.

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