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Scientific Articles

Open Access | Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication

March 14, 2010 - 10:23 -- Ingeborg van Schayk
Author(s): 
Shoichi Shimizu, Yoshio Osada, Tamotsu Kanazawa, Yoshiya Tanaka, Meiji Arai
Reference: 
Malaria Journal 2010, 9:73 (10 March 2010)

AZM inhibits parasite development in the mosquito stage, probably through the same mechanism as in the liver and blood stages. Such a multi-targeting anti-malarial, along with its safety, would be ideal for mass drug administration in malaria control programmes.

Open Access | Comparative detection of Plasmodium vivax and Plasmodium falciparum DNA in saliva and urine samples from symptomatic malaria patients in a low endemic area

March 14, 2010 - 10:17 -- Ingeborg van Schayk
Author(s): 
Pattakorn Buppan, Chaturong Putaporntip, Urassaya Pattanawong, Sunee Seethamchai, Somchai Jongwutiwes
Reference: 
Malaria Journal 2010, 9:72 (9 March 2010)

Saliva and urine samples could be alternative noninvasive sources of DNA for molecular detection of both P. falciparum and P. vivax. Further improvement of the detection method will offer an opportunity to use these samples for diagnosis of malaria.

Significance of Travel to Rural Areas as a Risk Factor for Malarial Anemia in an Urban Setting

March 12, 2010 - 16:43 -- Ingeborg van Schayk
Author(s): 
Jose G. Siri, Mark L. Wilson, Susan Murray, Daniel H. Rosen, John M. Vulule, Laurence Slutsker, AND Kim A. Lindblade
Reference: 
Am J Trop Med Hyg 2010;82 391-397

Control of severe malaria in an urban setting may be complicated by Plasmodium infections acquired elsewhere. Epidemiologic studies of urban malaria in low transmission settings should take travel history into account.

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Open Access | Geographic Structuring of the Plasmodium falciparum Sarco(endo)plasmic Reticulum Ca2+ ATPase (PfSERCA) Gene Diversity

March 12, 2010 - 16:33 -- Ingeborg van Schayk
Author(s): 
Ronan Jambou, Axel Martinelli, Pedro Cravo
Reference: 
PLoS ONE 5(2): e9424

To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America.

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Open Access : The Anopheles gambiae Odorant Binding Protein 1 (AgamOBP1) Mediates Indole Recognition in the Antennae of Female Mosquitoes

March 12, 2010 - 16:22 -- Ingeborg van Schayk
Author(s): 
Harald Biessmann, Evi Andronopoulou, Marika F. Walter et al.
Reference: 
PLoS ONE 5(3): e9471

This case represents the first documented instance of a specific A. gambiae OBP–ligand pairing combination, demonstrates the significance of OBPs in odor recognition, and can be expanded to the identification of other ligands for OBPs of Anopheles and other medically important insects.

Open Access | Dysregulation of Angiopoietins Is Associated with Placental Malaria and Low Birth Weight

March 12, 2010 - 15:43 -- Ingeborg van Schayk
Author(s): 
Karlee L. Silver, Kathleen Zhong, Rose G. F. Leke, Diane Wallace Taylor, Kevin C. Kain
Reference: 
PLoS ONE 5(3): e9481

These data support the hypothesis that dysregulation of angiopoietins is associated with PM and LBW outcomes, and suggest that ANG-1 and ANG-2 levels may be clinically informative biomarkers to identify P. falciparum-infected mothers at risk of LBW deliveries.

Open Access | Malaria Prevention with IPTp during Pregnancy Reduces Neonatal Mortality

March 12, 2010 - 15:32 -- Ingeborg van Schayk
Author(s): 
Clara Menéndez, Azucena Bardají, Betuel Sigauque, Sergi Sanz, John J. Aponte, Samuel Mabunda, Pedro L. Alonso
Reference: 
PLoS ONE 5(2): e9438

In the global context of a reduction of under-five mortality, neonatal mortality is an increasingly relevant component of this mortality. Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association.

Open Access | Duration of Protection Against Clinical Malaria Provided by Three Regimens of Intermittent Preventive Treatment in Tanzanian Infants

March 12, 2010 - 14:58 -- Ingeborg van Schayk
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Author(s): 
Matthew Cairns, Roly Gosling, Ilona Carneiro, Samwel Gesase, Jacklin F. Mosha, Ramadhan Hashim, Harparkash Kaur, Martha Lemnge, Frank W. Mosha, Brian Greenwood, Daniel Chandramohan
Reference: 
PLoS ONE 5(3): e9467

Intermittent preventive treatment in infants (IPTi) is a new malaria control tool. This study investigated how protection against malaria given by SP, chlorproguanil-dapsone (CD) and mefloquine (MQ), varied with time since administration of IPTi.

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Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death

March 11, 2010 - 14:00 -- Patrick Sampao
Author(s): 
Donelly A. van Schalkwyk, Xie W.A. Chan, Paola Misiano, Stefania Gagliardi, Carlo Farina, Kevin J. Saliba
Reference: 
Biochemical Pharmacology, Volume 79, Issue 9, 1 May 2010

The V-type H+-ATPase is critical during the intraerythrocytic stage of the human malaria parasite Plasmodium falciparum. Our data support the disruption of parasite pH regulation through inhibition of its V-type H+-ATPase as an antimalarial approach.

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Immunology: Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

March 11, 2010 - 13:46 -- Patrick Sampao
Author(s): 
Thornik Reimer, Michael H. Shaw, Luigi Franchi, Cevayir Coban, Ken J. Ishii, Shizuo Akira, Toshihiro Horii, Ana Rodriguez, Gabriel Núñez
Reference: 
European Journal of Immunology,Volume 40, Issue 3, March 2010, Pages: 764-769

Using the P. berghei ANKA infection model of mice, we investigated a potential involvement of Nlrp3 and the inflammasome in the pathogenesis of cerebral malaria.

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