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Scientific Articles

Brief report: Insecticide-Treated Nets Can Reduce Malaria Transmission by Mosquitoes Which Feed Outdoors

March 16, 2010 - 13:53 -- Ingeborg van Schayk
Author(s): 
Nicodem J. Govella, Fredros O. Okumu, AND Gerry F. Killeen
Reference: 
Am J Trop Med Hyg 2010;82 415-419

We adapt an established mathematical model of mosquito behavior and malaria transmission to illustrate how ITNs can achieve communal suppression of malaria transmission exposure, even where mosquito evade them and personal protection is modest.

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Brief report: Automated Detection of Malaria-Associated Pseudoeosinophilia and Abnormal WBC Scattergram by the Sysmex XE-2100 Hematology Analyzer: A Clinical Study with 1,801 Patients and Real-Time Quantitative PCR Analysis in Vivax Malaria-Endemic Area

March 16, 2010 - 13:47 -- Ingeborg van Schayk
Author(s): 
Jong-Ha Yoo, Jaewoo Song, Kyung-A Lee, Young-Kyu Sun, Young-Ah Kim, Tae Sung Park, AND Jong Rak Choi
Reference: 
Am J Trop Med Hyg 2010;82 412-414

Recently, the XE-2100 hematology analyzer was investigated in a rather small patient group; pseudoeosinophilia or abnormal white blood cell (WBC) scattergrams reported by this instrument were considered as significantly valuable diagnostic parameters in detecting vivax malaria.

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Design of Malaria Diagnostic Criteria for the Sysmex XE-2100 Hematology Analyzer

March 16, 2010 - 13:41 -- Ingeborg van Schayk
Author(s): 
Germán Campuzano-Zuluaga, Gonzalo Álvarez-Sánchez, Gloria Elcy Escobar-Gallo, Luz Marina Valencia-Zuluaga, Alexandra Marcela Ríos-Orrego, Adriana Pabón-Vidal, Andrés Felipe Miranda-Arboleda, Silvia Blair-Trujillo, AND Germán Campuzano-Maya
Reference: 
Am J Trop Med Hyg 2010;82 402-411

Thick film, the standard diagnostic procedure for malaria, is not always ordered promptly. A failsafe diagnostic strategy using an XE-2100 analyzer is proposed, and for this strategy, malaria diagnostic models for the XE-2100 were developed and tested for accuracy.

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The SYBR Green I Malaria Drug Sensitivity Assay: Performance in Low Parasitemia Samples

March 16, 2010 - 12:38 -- Ingeborg van Schayk
Author(s): 
Matthias G. Vossen, Sandra Pferschy, Peter Chiba, AND Harald Noedl
Reference: 
Am J Trop Med Hyg 2010;82 398-401

Our results suggest that the SYBR Green I assay is a fast and inexpensive malaria drug screening assay for laboratory use.

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Subpatent infection with nucleoside transporter 1-deficient Plasmodium blood stage parasites confers sterile protection against lethal malaria in mice

March 15, 2010 - 13:55 -- Ingeborg van Schayk
Author(s): 
Ahmed S. I. Aly, Megan J. Downie, Choukri Ben Mamoun and Stefan H. I. Kappe
Reference: 
Cellular Microbiology Early View

The study demonstrates that genetic manipulation provides a platform for the designed, complete attenuation of malaria parasite blood stages and suggests testing the safety and efficacy of P. falciparum NT1 knockout strains in humans.

Malaria hemozoin modulates susceptibility of immature monocyte-derived dendritic cells to HIV-1 infection by inducing a mature-like phenotype

March 15, 2010 - 11:18 -- Ingeborg van Schayk
Author(s): 
Juliette Diou, Mélanie R. Tardif, Corinne Barat and Michel J. Tremblay
Reference: 
Cellular Microbiology, Early View

There is still limited information about the putative impact of the malaria pigment hemozoin (HZ) on the dissemination of HIV-1. As so, we propose a premise where HZ present in human dendritic cells (DCs) could modulate HIV-1 transfer to CD4+ T cells. 

The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite

March 15, 2010 - 11:11 -- Ingeborg van Schayk
Author(s): 
Elyzana D. Putrianti, Anja Schmidt-Christensen, Iris Arnold, Volker T. Heussler, Kai Matuschewski and Olivier Silvie
Reference: 
Cellular Microbiology, Early View

In this study, we show by antibody localization and in vivo fluorescent tagging with the red fluorescent protein mCherry that the two P. berghei serine-type family members, PbSERA1 and PbSERA2, display differential expression towards the final stages of merozoite formation.

Open Access | The infectivity of the entomopathogenic fungus Beauveria bassiana to insecticide-resistant and susceptible Anopheles arabiensis mosquitoes at two different temperatures

March 14, 2010 - 10:36 -- Ingeborg van Schayk
Author(s): 
Christophe K Kikankie, Basil D Brooke, Bart GJ Knols, Lizette L Koekemoer, Marit Farenhorst, Richard H Hunt, Matthew B Thomas, Maureen Coetzee
Reference: 
Malaria Journal 2010, 9:71 (8 March 2010)

These results provide evidence that the entomopathogenic fungus B. bassiana has potential for use as an alternative vector control tool against insecticide-resistant mosquitoes under conditions typical of indoor resting environments.

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Open Access | Molecular surveillance of Plasmodium vivax dhfr and dhps mutations in isolates from Afghanistan

March 14, 2010 - 10:35 -- Ingeborg van Schayk
Author(s): 
Sedigheh Zakeri, Mandana Afsharpad, Faezeh Ghasemi, Ahmad Raeisi, Najibullah Safi, Waqar Butt, Hoda Atta, Navid D Djadid
Reference: 
Malaria Journal 2010, 9:75 (14 March 2010)

The present study shows a limited polymorphism in pvdhfr from Afghan isolates and provides important basic information to establish an epidemiological map of drug-resistant vivax malaria, and updating guidelines for anti-malarial policy in Afghanistan.

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Open Access | Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum

March 14, 2010 - 10:30 -- Ingeborg van Schayk
Author(s): 
Nahla B Gadalla, Salah Eldin Elzaki, Ebtihal Mukhtar, David C Warhurst, Badria El-Sayed, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:74 (12 March 2010)

Parasite resistance to the anti-malarial drug chloroquine is common in eastern Sudan. Dynamic within-host changes in the relative abundance of both sensitive and resistant Plasmodium falciparum parasites were examined in a cohort of chloroquine-treated patients presenting with uncomplicated falciparum malaria, using a novel allele-specific quantitative approach.

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