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Scientific Articles

Anopheles hervyi in Niger: no evidence for a role in Plasmodium falciparum transmission

February 24, 2010 - 10:50 -- Ingeborg van Schayk
Author(s): 
R. Labbo, C. Czeher, A. Djibrila, I. Arzika, I. Jeanne, J.B. Duchemin
Reference: 
Medical and Veterinary Entomology, Volume 24 Issue 1, Pages 62 - 65

In the present study, the use of CDC light traps showed it to be much more abundant than previously found but there was no evidence to suggest it was a malaria vector in this region.

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Modeling Erythropoiesis Subject to Malaria Infection

February 24, 2010 - 10:01 -- Ingeborg van Schayk
Author(s): 
Jeremy J. Thibodeaux
Reference: 
Mathematical Biosciences, In Press, Accepted Manuscript, Available online 12 February 2010

A mathematical model of erythropoiesis subject to malaria infection is developed by combining ideas from previous models that addressed only one of the two phenomena.

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Open Access | Universal Features of Post-Transcriptional Gene Regulation Are Critical for Plasmodium Zygote Development

February 24, 2010 - 09:46 -- Ingeborg van Schayk
Author(s): 
Gunnar R. Mair, Edwin Lasonder, Lindsey S. Garver, Blandine M. D. Franke-Fayard, Céline K. Carret, Joop C. A. G. Wiegant, Roeland W. Dirks, George Dimopoulos, Chris J. Janse, Andrew P. Waters
Reference: 
PLoS Pathog 6(2): e1000767

Using affinity purification coupled with mass-spectrometric analysis we identify a messenger ribonucleoprotein (mRNP) from Plasmodium berghei gametocytes defined by DOZI and the Sm-like factor CITH (homolog of worm CAR-I and fly Trailer Hitch).

Open Access | On the Diversity of Malaria Parasites in African Apes and the Origin of Plasmodium falciparum from Bonobos

February 23, 2010 - 12:13 -- Ingeborg van Schayk
Author(s): 
Krief S, Escalante AA, Pacheco MA, Mugisha L, André C, et al.
Reference: 
PLoS Pathog 6(2): e1000765

Finally, our data and that of others indicated that chimpanzees and bonobos maintain malaria parasites, to which humans are susceptible, a factor of some relevance to the renewed efforts to eradicate malaria.

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Open Access | Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine

February 23, 2010 - 12:02 -- Ingeborg van Schayk
Author(s): 
Jianping Song, Duong Socheat, Bo Tan, Prak Dara, Changsheng Deng, Sreng Sokunthea, Suon Seila, Fengzhen Ou, Huaxiang Jian, Guoqiao Li
Reference: 
Malaria Journal 2010, 9:57 (23 February 2010)

This is an important paper which demonstrates the utility of a mass drug treatment approach to malaria control in areas of relatively high transmission in south-western Cambodia.

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Open Access | Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon

February 19, 2010 - 15:53 -- Ingeborg van Schayk
Author(s): 
Solange Whegang Youdom, Rachida Tahar, Vincent Foumane Ngane, Georges Soula, Henri Gwet, Jean-Christophe Thalabard, Leonardo K Basco
Reference: 
Malaria Journal 2010, 9:56 (19 February 2010)

The relative effectiveness of various drug combinations was compared by a multi-treatment Bayesian random-effect meta-analysis.

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Plasmodium falciparum: In vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin

February 19, 2010 - 12:36 -- Kabogo Ndegwa
Author(s): 
Kirti Mishra, Dipjyoti Chakraborty, Amita Pal, Nrisingha Dey
Reference: 
Experimental Parasitology, Volume 124, Issue 4, April 2010, Pages 421-427

Quassia amara L. (Family Simaroubaceae) is known to have several medicinal properties including the activity against malaria. An HPLC method was employed for purification of the biologically active quassinoids; quassin (Q) and neo-quassin (NQ), further characterized by MALDI-TOF analyses.

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Synthesis and antiprotozoal activity of 4-arylcoumarins

February 19, 2010 - 12:34 -- Kabogo Ndegwa
Author(s): 
Jean-Thomas Pierson, Aurélien Dumètre, Sébastien Hutter, Florence Delmas, Michèle Laget, Jean-Pierre Finet, Nadine Azas, Sébastien Combes
Reference: 
European Journal of Medicinal Chemistry, Volume 45, Issue 3, March 2010, Pages 864-869

A large series of 4-arylcoumarins was synthesized by Suzuki-Miyaura cross-coupling reaction and evaluated for antiprotozoal activity against Plasmodium falciparum and Leishmania donovani.

Molecular characterization of Plasmodium vivax clinical isolates in Pakistan and Iran using pvmsp-1, pvmsp-3α and pvcsp genes as molecular markers

February 19, 2010 - 12:28 -- Kabogo Ndegwa
Author(s): 
Sedigheh Zakeri, Ahmad Raeisi, Mandana Afsharpad, Qutbuddin Kakar, Faezeh Ghasemi, Hoda Atta, Ghasem Zamani, Muhammad Suleiman Memon, Masoud Salehi, Navid Dinparast Djadid
Reference: 
Parasitology International, Volume 59, Issue 1, March 2010, Pages 15-21

In this study, the diversity of Plasmodium vivax populations circulating in Pakistan and Iran has been investigated by using circumsporozoite protein (csp) and merozoite surface proteins 1 and 3α (msp-1 and msp-3α) genes as genetic markers.

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The Accelerated Child Survival and Development programme in West Africa: a retrospective evaluation

February 19, 2010 - 12:27 -- Kabogo Ndegwa
Author(s): 
Jennifer Bryce, Kate Gilroy, Gareth Jones, Elizabeth Hazel, Robert E Black, Cesar G Victora
Reference: 
The Lancet, Volume 375, Issue 9714, 13 February 2010-19 February 2010, Pages 572-582

The ACSD project did not accelerate child survival in Benin and Mali focus districts relative to comparison areas, probably because coverage for effective treatment interventions for malaria and pneumonia were not accelerated, causes of neonatal deaths and undernutrition were not addressed, and stock shortages of insecticide-treated nets restricted the potential effect of this intervention.

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