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Scientific Articles

Phylogenetic relationships among speciends of Anopheles (Nyssorhynchus) (Diptera, Culicidae) based on nuclear and mitochondrial gene sequences

March 18, 2010 - 12:39 -- Patrick Sampao
Author(s): 
Brian P. Bourke, Peter G. Foster, Eduardo S. Bergo, Daniela C. Calado, Maria Anice M. Sallum
Reference: 
Acta Tropica, Volume 114, Issue 2, May 2010, Pages 88-96

Phylogenetic relationships among 21 species of mosquitoes in subgenus Nyssorhynchus were inferred from the nuclear white and mitochondrial NADH dehydrogenase subunit 6 (ND6) genes.

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Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate

March 18, 2010 - 12:28 -- Patrick Sampao
Author(s): 
Balwan Singh, Monica Cabrera-Mora, Jianlin Jiang, Mary Galinski, Alberto Moreno
Reference: 
Vaccine, Volume 28, Issue 14, 19 March 2010, Pages 2580-2592

These studies show that protective efficacy can be significantly improved by inclusion of an array of autologous promiscuous T cell epitopes in vaccine constructs.

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Sequences of the Plasmodium falciparum cytoadherence-linked asexual protein 9 implicated in malaria parasite invasion to erythrocytes

March 18, 2010 - 12:24 -- Patrick Sampao
Author(s): 
Carlos Giovanni Pinzón, Hernando Curtidor, Jeison García, Magnolia Vanegas, Carolina Vizcaíno, Manuel A. Patarroyo, Manuel E. Patarroyo
Reference: 
Vaccine, Volume 28, Issue 14, 19 March 2010, Pages 2653-2663

In this study, we synthesized the complete sequence of the CLAG-9 protein as 67 20-mer-long non-overlapped peptides and assessed their ability to bind to erythrocytes in receptor–ligand assays. 

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Antimalarial herbal remedies of Msambweni, Kenya

March 18, 2010 - 12:15 -- Patrick Sampao
Author(s): 
J.M. Nguta, J.M. Mbaria, D.W. Gakuya, P.K. Gathumbi, S.G. Kiama
Reference: 
Journal of Ethnopharmacology, Volume 128, Issue 2, 24 March 2010, Pages 424-432

This study was conducted to document medicinal plants that are traditionally used by the Msambweni community of Kenyan South Coast to treat malaria, where the disease is endemic.

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Synthesis, biophysical, and biological studies of wild-type and mutant psalmopeotoxins—Anti-malarial cysteine knot peptides from Psalmopoeus cambridgei

March 18, 2010 - 11:57 -- Patrick Sampao
Author(s): 
Pacharin Kamolkijkarn, Thitawan Prasertdee, Chawita Netirojjanakul, Pakornwit Sarnpitak, Somsak Ruchirawat, Songpon Deechongkit
Reference: 
Peptides, Volume 31, Issue 4, April 2010, Pages 533-540

Psalmopeotoxin I and II (PcFK1 and PcFK2), an anti-malarial peptide first extracted from Psalmopoeus cambridgei was synthesized and characterized

Anti-peptide antibodies differentiate between plasmodial lactate dehydrogenases

March 18, 2010 - 11:51 -- Patrick Sampao
Author(s): 
Ramona Hurdayal, Ikechukwu Achilonu, David Choveaux, Theresa H.T. Coetzer, J.P. Dean Goldring
Reference: 
Peptides, Volume 31, Issue 4, April 2010, Pages 525-532

Malaria lactate dehydrogenase, a glycolytic enzyme, is a malaria diagnostic target in lateral flow immunochromatographic rapid diagnostic tests. The study supports an anti-peptide antibody approach to the development of diagnostic reagents.

Open Access | Plasmodium vivax: Induction of CD4+CD25+FoxP3+ Regulatory T Cells during Infection Are Directly Associated with Level of Circulating Parasites

March 17, 2010 - 13:51 -- Ingeborg van Schayk
Author(s): 
Lilian Lacerda Bueno, Cristiane Guimarães Morais, Fernanda Fortes Araújo, Juliana Assis Silva Gomes, Rodrigo Corrêa-Oliveira, Irene Silva Soares, Marcus Vinícius Lacerda, Ricardo Toshio Fujiwara, Érika Martins Braga
Reference: 
PLoS ONE 5(3): e9623

Our findings indicate that malaria vivax infection lead to an increased number of activated Treg cells that are highly associated with parasite load, which probably exert an important contribution to the modulation of immune responses during P. vivax infection.

Open Access | Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

March 17, 2010 - 11:02 -- Ingeborg van Schayk
Author(s): 
Juan Wang, Liying Huang, Jian Li, Qiangwang Fan, Yicheng Long, Ying Li, Bing Zhou
Reference: 
PLoS ONE 5(3): e9582

We suggest that fundamental differences among mitochondria from different species delineate the action specificity of this class of drugs, and differing from many other drugs, the action specificity of artemisinins originates from their activation mechanism.

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Monitoring of failure of chloroquine treatment for Plasmodium vivax using polymerase chain reaction in Sanliurfa province, Turkey

March 17, 2010 - 10:46 -- Ingeborg van Schayk
Author(s): 
Fuat Dilmec, M. Ali Kurcer, Feridun Akkafa & Zeynep Simsek
Reference: 
Parasitology Research, Volume 106, Number 4 / March, 2010 : 783-788

Our target was to determine the Plasmodium species in the southeast region of Turkey and the therapeutic efficacy of CQ used in the treatment of malaria.

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Comparison of SYBR Green I-, PicoGreen-, and [3H]-hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine

March 17, 2010 - 10:38 -- Ingeborg van Schayk
Author(s): 
Oyindamola O. Abiodun, Grace O. Gbotosho, Edith O. Ajaiyeoba, Christian T. Happi, Sandra Hofer, Sergio Wittlin, Akin Sowunmi, Reto Brun & Ayoade M. J. Oduola
Reference: 
Parasitology Research, Volume 106, Number 4 / March, 2010 : 933-939

SG appears to be a cost-effective alternative for antimalarial drug screening and a viable technique that may facilitate antimalarial drug discovery process especially in developing countries.

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