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Scientific Articles

Protein-DNA Complex Is the Exclusive Malaria Parasite Component that Activates Dendritic Cells and Triggers Innate Immune Responses

March 21, 2010 - 11:06 -- Ingeborg van Schayk
Author(s): 
Xianzhu Wu, Nagaraj M. Gowda, Sanjeev Kumar, and D. Channe Gowda
Reference: 
J. Immunol. published 15 March 2010, 10.4049/jimmunol.0903824

Together, these results contribute substantially toward the understanding of malaria parasite-recognition mechanisms. More importantly, our finding that proteins and carbohydrate polymers are able to confer stimulatory activity to an otherwise inactive parasite DNA have important implications for the development of a vaccine against malaria.

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Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people

March 21, 2010 - 11:00 -- Ingeborg van Schayk
Author(s): 
Didier Menard, Celine Barnadas, Christiane Bouchier, Cara Henry-Halldin, Laurie R. Gray, Arsene Ratsimbasoa, Vincent Thonier, Jean-Francois Carod, Olivier Domarle, Yves Colin, Olivier Bertrand, Julien Picot, Christopher L. King, Brian T. Grimberg, Odile Mercereau-Puijalon, and Peter A. Zimmerman
Reference: 
PNAS. published 15 March 2010, 10.1073/pnas.0912496107

In Madagascar, P. vivax has broken through its dependence on the Duffy antigen for establishing human blood-stage infection and disease. Further studies are necessary to identify the parasite and host molecules that enable this Duffy-independent P. vivax invasion of human erythrocytes.

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Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein of blood stages

March 21, 2010 - 10:51 -- Ingeborg van Schayk
Author(s): 
Drew C. MacKellar, Matthew T. O'Neill, Ahmed S.I. Aly, John B. Sacci, Jr, Alan F. Cowman, and Stefan H.I. Kappe
Reference: 
Eukaryot. Cell. published 12 March 2010, 10.1128/EC.00336-09

We show that PF10_0164 is expressed in sporozoites and blood stages of P. falciparum, where it localizes to the parasitophorous vacuole, and is also exported to the host erythrocyte.

Letter: The demographic histories of the M and S molecular forms of Anopheles gambiae s.s.

March 21, 2010 - 10:41 -- Ingeborg van Schayk
Author(s): 
Jacob E. Crawford and Brian P. Lazzaro
Reference: 
Mol. Biol. Evol. published 11 March 2010, 10.1093/molbev/msq070

Population genetic tests have been employed to detect natural selection at suspected An. gambiae anti-malaria genes, but these tests have generally been compromised by the lack of demographically correct null models. Here, we used a coalescent simulation approach within a maximum likelihood framework to fit population growth, bottleneck and migration models to polymorphism data from Cameroonian An. gambiae.

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Images of Health: Unite to Fight Malaria!

March 21, 2010 - 10:27 -- Ingeborg van Schayk
Author(s): 
Liping Bu and Elizabeth Fee
Reference: 
Am J Public Health. 2010; 100:608

In this colorful Chinese poster, dating from the period of the Cultural Revolution, we see a young peasant woman spraying insecticide to kill mosquitoes.

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Reviews: Artemisinin resistance: current status and scenarios for containment

March 18, 2010 - 13:31 -- Patrick Sampao
Author(s): 
Arjen M. Dondorp, Shunmay Yeung, Lisa White, Chea Nguon, Nicholas P.J. Day, Duong Socheat, Lorenz von Seidlein
Reference: 
Nature Reviews Microbiology 8 March 2010

Artemisinin combination therapies are the first-line treatments for uncomplicated Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial artemisinin-resistant P. falciparum malaria has emerged on the Cambodia–Thailand border.

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Genetic polymorphism and effect of natural selection at domain I of apical membrane antigen-1 (AMA-1) in Plasmodium vivax isolates from Myanmar

March 18, 2010 - 13:04 -- Patrick Sampao
Author(s): 
Sung-Ung Moon, Byoung-Kuk Na, Jung-Mi Kang, Jung-Yeon Kim, Shin-Hyeong Cho, Yun-Kyu Park, Woon-Mok Sohn, Khin Lin, Tong-Soo Kim
Reference: 
Acta Tropica, Volume 114, Issue 2, May 2010, Pages 71-75

These results have significant implications in understanding the nature of P. vivax population circulating in Myanmar as well as providing useful information for malaria vaccine development based on this antigen.

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Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clones

March 18, 2010 - 13:01 -- Patrick Sampao
Author(s): 
Fátima Nogueira, Amalia Diez, Azar Radfar, Susana Pérez-Benavente, Virgilio E. do Rosario, Antonio Puyet, José M. Bautista
Reference: 
Acta Tropica, Volume 114, Issue 2, May 2010, Pages 109-115

To gain insight into early parasite stress response, mRNA expression profiles were determined for a set of 10 antioxidant defence genes in synchronized CQ-sensitive (3D7) and CQ-resistant (Dd2) clones under transient IC50 CQ-exposure (Dd2, 200 nM; 3D7, 14 nM).

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Malaria vectors in the Republic of Benin: Distribution of species and molecular forms of the Anopheles gambiae complex

March 18, 2010 - 12:54 -- Patrick Sampao
Author(s): 
Luc Djogbénou, Nicole Pasteur, Sahabi Bio-Bangana, Thierry Baldet, Seth R. Irish, Martin Akogbeto, Mylène Weill, Fabrice Chandre
Reference: 
Acta Tropica, Volume 114, Issue 2, May 2010, Pages 116-122

The objective of this study was to collate data on the relative frequencies of species and forms within the An. gambiae complex and to produce a map of their spatial distribution.

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Population structure of Anopheles gambiae along the Kenyan coast

March 18, 2010 - 12:47 -- Patrick Sampao
Author(s): 
Janet T. Midega, Ephantus J. Muturi, Frederick N. Baliraine, Charles M. Mbogo, John Githure, John C. Beier, Guiyun Yan
Reference: 
Acta Tropica, Volume 114, Issue 2, May 2010, Pages 103-108

These findings suggest that along the Kenyan coast, seasonality and site specific ecological factors can alter the genetic structure of A. gambiae s.s. populations.

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