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Scientific Articles

Open Access | Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials

March 23, 2010 - 21:10 -- Ingeborg van Schayk
Author(s): 
Michael T White, Jamie T Griffin, Chris J Drakeley, Azra C Ghani
Reference: 
Malaria Journal 2010, 9:82 (23 March 2010)

Phase III trials of the malaria vaccine, RTS,S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy.
 

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Open Access | Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models

March 23, 2010 - 21:06 -- Ingeborg van Schayk
Author(s): 
Ana Cecilia AX De-Oliveira, Renato S Carvalho, Flavio HM Paixao, Hellen S Tavares, Luciana S Gueiros, Carolina M Siqueira, Francisco JR Paumgartten
Reference: 
Malaria Journal 2010, 9:81 (22 March 2010)

This study was undertaken to evaluate the time course of CYP alterations in lethal (Plasmodium berghei ANKA) and non-lethal (Plasmodium chabaudi chabaudi) murine malaria.

Open Access | Annual variations in the number of malaria cases related to two different patterns of Anopheles darlingi transmission potential in the Maroni area of French Guiana

March 23, 2010 - 21:01 -- Ingeborg van Schayk
Author(s): 
Florence Fouque, Pascal Gaborit, Romuald Carinci, Jean Issaly, Romain Girod
Reference: 
Malaria Journal 2010, 9:80 (22 March 2010)

With an Annual Parasite Incidence (API) of 132.1, in the high and moderate risks zones, French Guiana has the second highest malaria incidence of South-America after Guyana (API=183.54) and far above Brazil (API=28.25). For the first time in the past 40 years, the mosquito bionomics was related to the malaria transmission patterns in French Guiana.

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Open Access | Mapping malaria incidence distribution that accounts for environmental factors in Maputo Province - Mozambique

March 23, 2010 - 20:56 -- Ingeborg van Schayk
Author(s): 
Orlando P Zacarias, Mikael Andersson
Reference: 
Malaria Journal 2010, 9:79 (21 March 2010)

The objective was to study if an association exists between the incidence of malaria and some weather parameters in tropical Maputo province, Mozambique.

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Open Access | Diversity in anopheline larval habitats and adult composition during the dry and wet seasons in Ouagadougou (Burkina Faso)

March 23, 2010 - 20:50 -- Ingeborg van Schayk
Author(s): 
Florence Fournet, Maud Cussac, Ali Ouari, Pierre-Erwann Meyer, Hyacinthe K Toe, Louis-Clement Gouagna, Roch K Dabire
Reference: 
Malaria Journal 2010, 9:78 (19 March 2010)

Several cases of malaria are frequently recorded during the dry period in Ouagadougou town (Burkina Faso). This has led to the design of a series of studies focusing on both parasitological and entomological investigations intended to provide relevant health data on the risk of local malaria transmission according to the way of urbanisation.

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Open Access | Antibodies against multiple merozoite surface antigens of the human malaria parasite Plasmodium falciparum inhibit parasite maturation and red blood cell invasion

March 23, 2010 - 20:40 -- Ingeborg van Schayk
Author(s): 
Ute Woehlbier, Christian Epp, Fiona Hackett, Michael J Blackman, Hermann Bujard
Reference: 
Malaria Journal 2010, 9:77 (18 March 2010)

The findings reported provide further support for the development of vaccines based on MSP-1/6/7 and AMA-1, which would possibly include a combination of these antigens.

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Open Access | Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9) for malaria

March 23, 2010 - 20:31 -- Ingeborg van Schayk
Author(s): 
Heng Peng, Yunfei Hu, Aiguo Zhou, Changwen Jin, Weiqing Pan
Reference: 
Malaria Journal 2010, 9:76 (18 March 2010)

These data indicate that the fusion of AMA-1(III) and MSP1-19 as chimeric protein did not change their structures, supporting the use of the chimeric protein as a potential malaria vaccine.

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Open Access | An extra-domiciliary method of delivering entomopathogenic fungus, Metharizium anisopliae IP 46 for controlling adult populations of the malaria vector, Anopheles arabiensis

March 21, 2010 - 11:27 -- Ingeborg van Schayk
Author(s): 
Dickson W Lwetoijera , Robert D Sumaye , Edith P Madumla , Deogratius R Kavishe, Ladlaus L Mnyone, Tanya L Russell and Fredros O Okumu
Reference: 
Parasites & Vectors 2010, 3:18doi:10.1186/1756-3305-3-18

We conclude that high infection rates of entomopathogenic fungi on wild malaria vectors and possibly significant disruption of malaria transmission can be achieved if the fungus is delivered using optimally located outdoor odor-baited stations.

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Loss of Ability To Self-Heal Malaria upon Taurine Transporter Deletion

March 21, 2010 - 11:18 -- Ingeborg van Schayk
Author(s): 
Denis Delic, Ulrich Warskulat, Elena Borsch, Saad Al-Qahtani, Saleh Al-Quraishi, Dieter Haussinger, and Frank Wunderlich
Reference: 
Infect. Immun. 2010;78 1642-1649

Deletion of the taurine transporter gene (taut) results in lowered levels of taurine, the most abundant amino acid in mammals. Here, we show that taut–/– mice have lost their ability to self-heal blood-stage infections with Plasmodium chabaudi malaria. 

Both Hemolytic Anemia and Malaria Parasite-Specific Factors Increase Susceptibility to Nontyphoidal Salmonella enterica Serovar Typhimurium Infection in Mice

March 21, 2010 - 11:14 -- Ingeborg van Schayk
Author(s): 
Christelle M. Roux, Brian P. Butler, Jennifer Y. Chau, Tatiane A. Paixao, Kong Wai Cheung, Renato L. Santos, Shirley Luckhart, and Renee M. Tsolis
Reference: 
Infect. Immun. 2010;78 1520-1527

Here we established a model for oral Salmonella enterica serotype Typhimurium challenge in mice infected with Plasmodium yoelii nigeriensis. Collectively, studies establishing a mouse model for this coinfection suggest that multiple distinct malaria-induced immune defects contribute to increased susceptibility to S. Typhimurium.

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