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Scientific Articles

Nucleosome landscape and control of transcription in the human malaria parasite

January 10, 2010 - 15:26 -- Ingeborg van Schayk
Author(s): 
Nadia Ponts, Elena Y. Harris, Jacques Prudhomme, Ivan Wick, Colleen Eckhardt-Ludka, Glenn R. Hicks, Gary Hardiman, Stefano Lonardi, and Karine G. Le Roch
Reference: 
Genome Res. published 6 January 2010

Our results demonstrate that the processes driving gene expression in Plasmodium challenge the classical eukaryotic model of transcriptional regulation occurring mostly at the transcription initiation level.

Open Access | The Malaria Parasite Cyclic GMP-Dependent Protein Kinase Plays a Central Role in Blood-Stage Schizogony

January 10, 2010 - 15:20 -- Ingeborg van Schayk
Author(s): 
Helen M. Taylor, Louisa McRobert, Munira Grainger, Audrey Sicard, Anton R. Dluzewski, Christine S. Hopp, Anthony A. Holder, and David A. Baker
Reference: 
Eukaryotic Cell 2010;9 37-45

In the present study we examined the role of PfPKG in the asexual blood-stage of the parasite life cycle, the stage that causes malaria pathology.

Open Access | Difficulties in organizing first indoor spray programme against malaria in Angola under the President's Malaria Initiative

January 10, 2010 - 15:18 -- Ingeborg van Schayk
Author(s): 
Martinho Somandjinga; Manuel Lluberas; William R Jobin
Reference: 
Bull World Health Organ vol.87 no.11 Genebra Nov. 2009

Unfortunately malaria transmission in Africa is often assessed using routine administrative reports from local health units, which are plagued by sporadic reporting failures. It is unfortunate that WHO is also trying to plan and evaluate its malaria control efforts based on these same kinds of inadequate administrative reports.

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Imported Chloroquine-Resistant Plasmodium vivax in Singapore: Case Report and Literature Review

January 10, 2010 - 15:15 -- Ingeborg van Schayk
Author(s): 
Poh Lian Lim, Ying Juan Mok, David C. Lye, Yee Sin Leo
Reference: 
Journal of Travel Medicine, Volume 17 Issue 1, Pages 69 - 71

We report a 58-year-old business traveler who returned from Indonesia and experienced relapse due to CRPV. The epidemiology and diagnostic challenges of CRPV for travel medicine clinicians are reviewed.

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Open Access | Hemozoin (Malarial Pigment) Directly Promotes Apoptosis of Erythroid Precursors

January 10, 2010 - 15:13 -- Ingeborg van Schayk
Author(s): 
Abigail A. Lamikanra, Michel Theron, Taco W. A. Kooij, David J. Roberts
Reference: 
PLoS ONE 4(12): e8446

Severe malarial anemia is the most common syndrome of severe malaria in endemic areas.

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Open Access | Contrasting Population Structures of the Genes Encoding Ten Leading Vaccine-Candidate Antigens of the Human Malaria Parasite, Plasmodium falciparum

January 10, 2010 - 15:11 -- Ingeborg van Schayk
Author(s): 
Alyssa E. Barry, Lee Schultz, Caroline O. Buckee, John C. Reeder
Reference: 
PLoS ONE 4(12): e8497

The extensive diversity of Plasmodium falciparum antigens is a major obstacle to a broadly effective malaria vaccine but population genetics has rarely been used to guide vaccine design.

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Evolutionary genetic insights into Plasmodium falciparum functional genes

January 10, 2010 - 15:09 -- Ingeborg van Schayk
Author(s): 
Meenu Sharma, Aditya P. Dash & Aparup Das
Reference: 
Parasitology Research, Volume 106, Number 2 / January, 2010 : 349-355

The study provides, for the first time, a detail evolutionary analysis of functional genes of a devastating malaria parasite.

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Antiplasmodial activity and toxicity of crude extracts from alternatives parts of plants widely used for the treatment of malaria in Burkina Faso: contribution for their preservation

January 10, 2010 - 15:06 -- Ingeborg van Schayk
Author(s): 
Adama Gansané, Souleymane Sanon, Lamoussa P. Ouattara, Abdoulaye Traoré, Sébastien Hutter, Evelyne Ollivier, Nadine Azas, Alfred S. Traore, Innocent P. Guissou, Sodiomon B. Sirima & Issa Nebié
Reference: 
Parasitology Research, Volume 106, Number 2 / January, 2010 : 335-340

In order to prevent the destruction of the ecology and to sustain the flora mainly for medicinal plants, we investigated on alternative parts taken from four plants already known to display antiplasmodial activities and largely used by traditional healers in sub-Saharan Africa.

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Open Access | The interaction of seasonal forcing and immunity and the resonance dynamics of malaria

January 10, 2010 - 15:04 -- Ingeborg van Schayk
Author(s): 
Dylan Z. Childs and Michael Boots
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J R Soc Interface. 2010; 7:309-319.

We discuss the implications of our results for understanding prevalence patterns in long-term malaria datasets from Kenya that show multi-annual cycles and one from Thailand that does not and discuss the possible implications of treatment.

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Neither Mosquito Saliva nor Immunity to Saliva Has a Detectable Effect on the Infectivity of Plasmodium Sporozoites Injected into Mice

January 10, 2010 - 15:01 -- Ingeborg van Schayk
Author(s): 
Chahnaz Kebaier, Tatiana Voza, and Jerome Vanderberg
Reference: 
Infect. Immun. 2010;78 545-551

Prior studies had suggested that saliva may enhance sporozoite infectivity. Using rodent malaria models (Plasmodium berghei and P. yoelii), we were unable to show that saliva had any detectable effect on sporozoite infectivity.

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