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Scientific Articles

Open Access | Review: In vitro selection of Plasmodium falciparum drug-resistant parasite lines

March 10, 2010 - 13:43 -- Ingeborg van Schayk
Author(s): 
Alexis Nzila and Leah Mwai
Reference: 
J. Antimicrob. Chemother. 2010 65: 390-398; doi:10.1093/jac/dkp449

In this review, we discuss the key parameters that impact on the efficiency of the in vitro selection of resistance, and propose strategies to improve and streamline this process.

Open Access | Assessing the future threat from vivax malaria in the United Kingdom using two markedly different modelling approaches

March 9, 2010 - 14:10 -- Ingeborg van Schayk
Author(s): 
Steven W Lindsay, David G Hole, Robert A Hutchinson, Shane A Richards, Steven G Willis
Reference: 
Malaria Journal 2010, 9:70 (5 March 2010)

Although the future climate in the UK is favourable for the transmission of vivax malaria, the future risk of locally transmitted malaria is considered low because of low vector biting rates and the low probability of vectors feeding on a malaria-infected person.

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Open Access | Distribution of the main malaria vectors in Kenya

March 9, 2010 - 14:05 -- Ingeborg van Schayk
Author(s): 
Robi M Okara, Marianne E Sinka, Noboru Minakawa, Charles M Mbogo, Simon I Hay, Robert W Snow
Reference: 
Malaria Journal 2010, 9:69 (4 March 2010)

The data collated here are published alongside this paper where it may help guide future sampling location decisions, help with the planning of vector control suites nationally and encourage broader research inquiry into vector species niche modelling.

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Open Access | Markers of anti-malarial drug resistance in Plasmodium falciparum isolates from Swaziland: identification of pfmdr1-86F in natural parasite isolates

March 9, 2010 - 13:58 -- Ingeborg van Schayk
Author(s): 
Sabelo V Dlamini, Khalid Beshir, Colin J Sutherland
Reference: 
Malaria Journal 2010, 9:68 (3 March 2010)

Anti-malarial policy changes in neighbouring countries may have had an impact on the prevalence of molecular markers of anti-malarial resistance in Swaziland, and it is hoped that this new information will add to understanding of the regional anti-malarial resistance map.

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Molecular basis of odor coding in the malaria vector mosquito Anopheles gambiae

March 9, 2010 - 13:50 -- Ingeborg van Schayk
Author(s): 
Guirong Wang, Allison F. Carey, John R. Carlson, and Laurence J. Zwiebel
Reference: 
PNAS March 2, 2010 vol. 107 no. 9 4418-4423

his study provides a comprehensive overview of olfactory coding mechanisms of An. gambiae that ultimately may aid in fostering the design and development of olfactory-based strategies for reducing the transmission of malaria and other mosquito-borne diseases.

Systematic review: Low-quality evidence that atovaquone-proguanil and doxycycline are better tolerated prophylactic antimalarial regimens in travellers than mefloquine

March 9, 2010 - 13:03 -- Ingeborg van Schayk
Author(s): 
Michael Hawkes
Reference: 
Evid. Based Nurs. 2010; 13:19-20

he scope of this review is the prevention of Plasmodium falciparum, which is the malaria species that causes the overwhelming majority of severe disease and death, and which in many areas of the world is frequently resistant to the classical antimalarial agent chloroquine.

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Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii

March 9, 2010 - 12:36 -- Ingeborg van Schayk
Author(s): 
Liene Dhooghe, Sheila Maregesi, Irena Mincheva, Daneel Ferreira, Jannie P.J. Marais, Filip Lemière, An Matheeussen, Paul Cos, Louis Maes, Arnold Vlietinck, Sandra Apers and Luc Pieters
Reference: 
Phytochemistry Article in Press, Corrected Proof

Preliminary screening of a series of medicinal plants, traditionally used in Tanzania, showed an IC50 of 15.6–31.2 μg/ml for the crude extract of the root of Ormocarpum kirkii S. Moore (Papilionaceae) against Plasmodium falciparum. A bioguided isolation was performed in order to isolate the active constituents.

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The Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparum

March 9, 2010 - 12:11 -- Ingeborg van Schayk
Author(s): 
Jun Miao, Jinfang Li, Qi Fan, Xiaolian Li, Xinyi Li, and Liwang Cui
Reference: 
J. Cell Sci. published 2 March 2010, 10.1242/jcs.059824

In this study we determined the function of PfPuf2, a member of the Puf family of translational repressors, in gametocytogenesis of Plasmodium falciparum.

p53 is required for chloroquine-induced atheroprotection but not insulin sensitization

March 9, 2010 - 12:02 -- Ingeborg van Schayk
Author(s): 
Babak Razani, Chu Feng and Clay F. Semenkovich
Reference: 
J. Lipid Res., doi:10.1194/jlr.M003681

ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. The anti-malarial drug chloroquine activates ATM signaling and improves metabolic phenotypes in mice.

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Role of cis-regulatory elements on the ring-specific hrp3 promoter in the human parasite Plasmodium falciparum

March 8, 2010 - 12:17 -- Ingeborg van Schayk
Author(s): 
Anusha M. Gopalakrishnan and Carlos López-Estraño
Reference: 
Parasitology Research, Online First

Together, our results indicate the presence of multiple mechanisms of gene regulation in the parasite.

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