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Scientific Articles

Hemapheresis: Considerations on the use of adjunct red blood cell exchange transfusion in the treatment of severe Plasmodium falciparum malaria

March 31, 2010 - 12:13 -- Patrick Sampao
Author(s): 
Suresh G. Shelat, Jason P. Lott, Matthew S. Braga
Reference: 
Transfusion, Volume 50, Issue 4, Date: April 2010, Pages: 875-880

Discussed are the medical and technical considerations on the use of adjunctive ET for severe P. falciparum infection and a review of the literature of the use of adjunct ET in the treatment of severe P. falciparum malaria.

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Two Case Reports of Successful Therapeutic Erythrocytapheresis as an Adjunctive Therapy in Severe Falciparum Malaria

March 31, 2010 - 12:07 -- Patrick Sampao
Author(s): 
Hae-Sun Chung, Kyong Ran Peck, Dae-Won Kim
Reference: 
Therapeutic Apheresis and Dialysis, Volume 14, Issue 2, April 2010, Pages: 230-233

For many years, erythrocytapheresis has been used for the rapid removal of parasites in patients with severe and complicated malaria. Here, we report two cases of severe Plasmodium falciparum infection treated by erythrocytapheresis in addition to antimalarial chemotherapy.

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Promiscuous T-cell epitopes of Plasmodium merozoite surface protein 9 (PvMSP9) induces IFN-γ and IL-4 responses in individuals naturally exposed to malaria in the Brazilian Amazon

March 31, 2010 - 12:04 -- Patrick Sampao
Author(s): 
J.C. Lima-Junior, D.M. Banic, T.M. Tran, V.S.E. Meyer, S.G. De-Simone, F. Santos, L.C.S. Porto, M.T.Q. Marques, A. Moreno, J.W. Barnwell, M.R. Galinski, J. Oliveira-Ferreira
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3185-3191

Plasmodium vivax merozoite surface protein (PvMSP9) stimulates both cellular and humoral immune responses in individuals who are naturally infected by this parasite species. 

Adenovectors induce functional antibodies capable of potent inhibition of blood stage malaria parasite growth

March 31, 2010 - 11:30 -- Patrick Sampao
Author(s): 
Joseph T. Bruder, Maureen E. Stefaniak, Noelle B. Patterson, Ping Chen, Svetlana Konovalova, Keith Limbach, Joseph J. Campo, Damodar Ettyreddy, Sheng Li, Filip Dubovsky, Thomas L. Richie, C. Richter King, Carole A. Long, Denise L. Doolan
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3201-3210

These data highlight the importance of rational vaccine design and support the advancement of adenovector delivery technology for a malaria vaccine.

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Bottleneck effects on vaccine-candidate antigen diversity of malaria parasites in Thailand

March 31, 2010 - 11:26 -- Patrick Sampao
Author(s): 
Somchai Jongwutiwes, Chaturong Putaporntip, Austin L. Hughes
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3112-3117

These results suggest a two-pronged strategy for malaria eradication: (1) strenuous non-vaccine control measures that will cause a severe population bottleneck in the parasite; and (2) a subsequent local vaccine focused on one or a few locally occurring alleles at antigen-encoding loci.

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Stability and potency of the Plasmodium falciparum MSP1-19/AMA-1(III) chimeric vaccine candidate with Montanide ISA720 adjuvant

March 31, 2010 - 11:24 -- Patrick Sampao
Author(s): 
Xiangyang Xue, Feng Ding, Qingfeng Zhang, Xuegong Pan, Li Qu, Weiqing Pan
Reference: 
Vaccine, Volume 28, Issue 18, 19 April 2010, Pages 3152-3158

These data indicated that the vaccine emulsion was stable over long periods of storage and maintained both its physical and biological properties.

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Vaxfectin® enhances both antibody and in vitro T cell responses to each component of a 5-gene Plasmodium falciparum plasmid DNA vaccine mixture administered at low doses

March 31, 2010 - 11:19 -- Patrick Sampao
Author(s): 
Martha Sedegah, William O. Rogers, Maria Belmonte, Arnel Belmonte, Glenna Banania, Noelle B. Patterson, Denis Rusalov, Marilyn Ferrari, Thomas L. Richie, Denise L. Doolan
Reference: 
Vaccine, Volume 28, Issue 17, 9 April 2010, Pages 3055-3065

These data showing that Vaxfectin® can enhance the immunogenicity of plasmid DNA vaccines administered at low doses per body weight, and in combinations, has important clinical implications for the development of a vaccine against malaria, as well as against other public health threats.

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Helminth infection impairs the immunogenicity of a Plasmodium falciparum DNA vaccine, but not irradiated sporozoites, in mice

March 31, 2010 - 11:17 -- Patrick Sampao
Author(s): 
Gregory S. Noland, Debabani Roy Chowdhury, Joseph F. Urban Jr., Fidel Zavala, Nirbhay Kumar
Reference: 
Vaccine, Volume 28, Issue 17, 9 April 2010, Pages 2917-2923

Here we compare the response to two prototype malaria vaccines: a transmission blocking DNA vaccine based on Pfs25, and a pre-erythrocytic malaria vaccine based on irradiated sporozoites in mice infected with the intestinal nematode Heligmosomoides polygyrus.

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Immunogenic properties of a recombinant fusion protein containing the C-terminal 19 kDa of Plasmodium falciparum merozoite surface protein-1 and the innate immunity agonist FliC flagellin of Salmonella Typhimurium

March 31, 2010 - 11:14 -- Patrick Sampao
Author(s): 
Daniel Y. Bargieri, Juliana A. Leite, Stefanie C.P. Lopes, Maria Elisabete Sbrogio-Almeida, Catarina J.M. Braga, Luis C.S. Ferreira, Irene S. Soares, Fabio T.M. Costa, Mauricio M. Rodrigues
Reference: 
Vaccine, Volume 28, Issue 16, 1 April 2010, Pages 2818-2826

In summary, these results extend our previous observations and further demonstrate that fusion of the innate immunity agonist FliC to Plasmodium antigens is a promising alternative to improve their immunogenicity.

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Review: Plasmodium falciparum GPI toxin: A common foe for man and mosquito

March 31, 2010 - 11:11 -- Patrick Sampao
Author(s): 
Romanico B.G. Arrighi, Ingrid Faye
Reference: 
Acta Tropica, Volume 114, Issue 3, June 2010, Pages 162-165

In this mini-review we look at the increased interest in understanding the way that malaria antigens are recognized in the mosquito, and how this relates to a better understanding of the interactions between the malaria parasite and both human and vector.

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