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Scientific Articles

Open Access | Laboratory evaluation of traditionally used plant-based insect repellent against the malaria vector Anopheles arabiensis Patton (Diptera: Culicidae)

April 7, 2010 - 11:54 -- Kabogo Ndegwa
Author(s): 
Karunamoorthi K, Ilango K, Murugan K.
Reference: 
Parasitology Research, Volume 106, Number 5 April, 2010

Globally, Cymbopogon citratus is renowned for its therapeutic values. Above and beyond, due to its user- as well as environmental-friendly nature, it should be promoted among the marginalized populations in order to reduce man-vector contact.

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Open Access | FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil

April 7, 2010 - 11:43 -- Kabogo Ndegwa
Author(s): 
Sérgio Roberto Lopes Albuquerque, Francimary de Oliveira Cavalcante, Edalton Cesar Sanguino, Lucianna Tezza, Fernanda Chacon, Lilian Castilho and Maria Cristina dos Santos
Reference: 
Parasitology Research, Volume 106, Number 5 April, 2010

These results suggest that natural adaptations, in malaria-endemic regions, could be leading to the arising of partial defense mechanisms against P. vivax, which is different from the previously described in African descents, as well as adaptations that could be increasing the susceptibility of human to this kind of malaria.

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Open Access | Quantifying Aggregated Uncertainty in Plasmodium falciparum Malaria Prevalence and Populations at Risk via Efficient Space-Time Geostatistical Joint Simulation

April 7, 2010 - 11:28 -- Kabogo Ndegwa
Author(s): 
Peter W. Gething, Anand P. Patil, Simon I. Hay
Reference: 
PLoS Comput Biol 6(4): e1000724

Risk maps estimating the spatial distribution of infectious diseases are required to guide public health policy from local to global scales. The advent of model-based geostatistics (MBG) has allowed these maps to be generated in a formal statistical framework, providing robust metrics of map uncertainty that enhances their utility for decision-makers.

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Synthesis and structure–activity relationships of antimalarial 4-oxo-3-carboxyl quinolones

April 7, 2010 - 11:14 -- Kabogo Ndegwa
Author(s): 
Yiqun Zhang, W. Armand Guiguemde, Martina Sigal, Fangyi Zhu, Michele C. Connelly, Solomon Nwaka, R. Kiplin Guy
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 7, 1 April 2010, Pages 2756-2766

The increasing prevalence of multi-drug-resistant Plasmodium falciparum drives the ongoing need for the development of new antimalarial drugs.

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

April 7, 2010 - 11:00 -- Kabogo Ndegwa
Author(s): 
James Chadwick, Michael Jones, Amy E. Mercer, Paul A. Stocks, Stephen A. Ward, B. Kevin Park, Paul M. O’Neill
Reference: 
Bioorganic & Medicinal Chemistry, Volume 18, Issue 7, 1 April 2010, Pages 2586-2597

A series of artemisinin–spermidine conjugates designed to utilise the upregulated polyamine transporter found in cancer cells have been prepared.

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Natural cocoa as diet-mediated antimalarial prophylaxis

April 7, 2010 - 09:50 -- Patrick Sampao
Author(s): 
F.K. Addai
Reference: 
Medical Hypotheses, Volume 74, Issue 5, May 2010, Pages 825-830

A hypothesis is formulated that cocoa offers a diet-mediated antimalarial prophylaxis; and an additional novel tool in the fight against the legendary scourge.

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HO-1 polymorphism as a genetic determinant behind the malaria resistance afforded by haemolytic disorders

April 7, 2010 - 08:46 -- Patrick Sampao
Author(s): 
D. Garcia-Santos, J.A.B. Chies
Reference: 
Medical Hypotheses, Volume 74, Issue 5, May 2010, Pages 807-813

The rate limiting enzyme heme oxygenase I (HO-1), responsible for the catabolism of the free heme in the body, is an important resistance factor in malaria and is also important in the physiopathology of haemolytic diseases.

Development of binding assays to screen ligands for Plasmodium falciparum thioredoxin and glutathione reductases by ultrafiltration and liquid chromatography/mass spectrometry

April 7, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Vanisree Mulabagal, Angela I. Calderón
Reference: 
Journal of Chromatography B, Volume 878, Issues 13-14, 15 April 2010, Pages 987-993

To identify potential lead compounds for malaria drug discovery, ultrafiltration and liquid chromatography and mass spectrometry (UF and LC/MS) based binding assays were developed.

Differential expansion of the merozoite surface protein (msp)-7 gene family in Plasmodium species under a birth-and-death model of evolution

April 7, 2010 - 06:30 -- Patrick Sampao
Author(s): 
Diego Garzón-Ospina, Luis F. Cadavid, and Manuel A. Patarroyo
Reference: 
Molecular Phylogenetics and Evolution, Volume 55, Issue 2, May 2010, Pages 399-408

We conclude that evolution of the msp-7 family is in agreement with a birth-and-death model of evolution, as msp-7 genes have expanded until reaching an optimal gene copy number in each Plasmodium species in order to adapt to different niches.

Neuroimaging findings in children with retinopathy-confirmed cerebral malaria

April 6, 2010 - 15:56 -- Kabogo Ndegwa
Author(s): 
Michael J. Potchen, Gretchen L. Birbeck, J. Kevin DeMarco, Sam D. Kampondeni, Nicholas Beare, Malcolm E. Molyneux, Terrie E. Taylor
Reference: 
European Journal of Radiology, Volume 74, Issue 1, April 2010, Pages 262-268

The identification of pre-existing imaging abnormalities in acute cerebral malaria suggests that population-based studies are required to establish the rate and nature of incidental imaging abnormalities in Malawi.

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