The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11071 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

A Comparison of Two Short-Course Primaquine Regimens for the Treatment and Radical Cure of Plasmodium vivax Malaria in Thailand

April 13, 2010 - 08:40 -- Patrick Sampao
Author(s): 
Sasithon Pukrittayakamee, Mallika Imwong, Kesinee Chotivanich, Pratap Singhasivanon, Nicholas P. J. Day, AND Nicholas J. White
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 542-547

These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different.

Person: 
Country: 
Medical Condition: 
Medical Treatment: 

TLR9 Polymorphisms Are Associated with Altered IFN-{gamma} Levels in Children with Cerebral Malaria

April 13, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Nadia A. Sam-A., Jennifer A. G., et al
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 548-555

We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.

Person: 
Country: 

Case report: Severe Congenital Malaria Acquired in utero

April 13, 2010 - 08:18 -- Patrick Sampao
Author(s): 
Jeanne R. P., Afdal H., et al.,
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82: 4, 2010, pp. 563-565

We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome.

Person: 

Syndromic Diagnosis of Malaria in Rural Sierra Leone and Proposed Additions to the National Integrated Management of Childhood Illness Guidelines for Fever

April 13, 2010 - 08:08 -- Patrick Sampao
Author(s): 
Obinna N. Nnedu, Bryan Rimel, Carey Terry, Heidi Jalloh-Vos, Brima Baryon, AND Daniel G. Bausch
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 525-528

In a multivariate analysis, splenomegaly (P = 0.04) was the only clinical sign significantly associated with laboratory-confirmed malaria, and sleeping under a bed net was protective (P = 0.05). Our findings show that clinical malaria is diagnosed relatively accurately in rural Sierra Leone.

Person: 
Country: 
Medical Condition: 
Medical Treatment: 

Malaria Parasitemia and CD4 T Cell Count, Viral Load, and Adverse HIV Outcomes Among HIV-Infected Pregnant Women in Tanzania

April 13, 2010 - 07:40 -- Patrick Sampao
Author(s): 
Molly F. Franke, Donna Spiegelman, Amara Ezeamama, Said Aboud, Gernard I. Msamanga, Saurabh Mehta, AND Wafaie W. Fawzi
Reference: 
American Journal of Tropical Medicine Hygien, Vol 82 : 4, 2010, pp. 556-562

Parasitemia level was nonlinearly associated with viral load at baseline and among measurements taken > 90 days post-baseline; women with low baseline parasitemia, versus none, had higher viral loads at both time points.

Country: 
Medical Condition: 

Genetic diversity of the Plasmodium vivax merozoite surface protein-5 locus from diverse geographic origins

April 13, 2010 - 07:13 -- Kabogo Ndegwa
Author(s): 
Chaturong Putaporntip, Rachanee Udomsangpetch, Urassaya Pattanawong, Liwang Cui, Somchai Jongwutiwes
Reference: 
Gene, Volume 456, Issues 1-2, 15 May 2010, Pages 24-35

We have conducted a comprehensive analysis of PvMsp-5 by sequencing the entire gene of four parasite populations from northwestern Thailand (n = 73), southern Thailand (n = 53), Indonesia (n = 25) and Brazil (n = 24), and five isolates from other endemic areas. Results reveal that exon I exhibits a significantly higher level of nucleotide diversity at both synonymous and nonsynonymous sites than exon II (p < 0.01).

Brief Report: High Heritability of Malaria Parasite Clearance Rate Indicates a Genetic Basis for Artemisinin Resistance in Western Cambodia

April 9, 2010 - 17:52 -- Ingeborg van Schayk
Author(s): 
Tim J. C. Anderson, Shalini Nair, Standwell Nkhoma, Jeff T. Williams, Mallika Imwong, Poravuth Yi, Duong Socheat, Debashish Das, Kesinee Chotivanich, Nicholas P. J. Day, Nicholas J. White, and Arjen M. Dondorp
Reference: 
The Journal of Infectious Diseases 2010;201:1326–1330

In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population.

Country: 

Antibodies to Chondroitin Sulfate A–Binding Infected Erythrocytes: Dynamics and Protection during Pregnancy in Women Receiving Intermittent Preventive Treatment

April 9, 2010 - 17:46 -- Ingeborg van Schayk
Author(s): 
Elizabeth H. Aitken, Bernard Mbewe, Mari Luntamo, Ken Maleta, Teija Kulmala, Marc‐James Friso, Freya J. I. Fowkes, James G. Beeson, Per Ashorn, and Stephen J. Rogerson
Reference: 
The Journal of Infectious Diseases 2010;201:1316–1325

Levels of IgG antibody to pregnancy‐specific VSAs decrease during receipt of IPTp. Antibody levels in early pregnancy did not predict clinical outcome. IPTp and decreasing malaria prevalence pose challenges for the evaluation of novel interventions for malaria during pregnancy.

Medical Treatment: 

Antibiotics in Malaria Therapy and their Effect on the Parasite Apicoplast

April 9, 2010 - 14:53 -- Patrick Sampao
Author(s): 
Pradel, G.; Schlitzer, M.
Reference: 
Current Molecular Medicine, Volume 10, Number 3, April 2010, pp. 335-349

This review will describe the effect of classical antibacterial agents against malaria parasites and the use of some of these compounds in clinical settings.

Medical Condition: 

Open Access | A call to action: addressing the challenge of artemisinin-resistant malaria

April 9, 2010 - 13:59 -- Patrick Sampao
Author(s): 
Stephen P Kachur, John R MacArthur and Laurence Slutsker
Reference: 
Expert Review of Anti-infective Therapy, Volume 8

Malaria control programs and their donor partners across the endemic world should urgently revitalize efforts to characterize and track potentially resistant parasites, especially where they are investing heavily in rolling out access to ACTs.

Medical Condition: 
Medical Treatment: 

Pages

Subscribe to Scientific Articles