These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different.
We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.
We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome.
In a multivariate analysis, splenomegaly (P = 0.04) was the only clinical sign significantly associated with laboratory-confirmed malaria, and sleeping under a bed net was protective (P = 0.05). Our findings show that clinical malaria is diagnosed relatively accurately in rural Sierra Leone.
Parasitemia level was nonlinearly associated with viral load at baseline and among measurements taken > 90 days post-baseline; women with low baseline parasitemia, versus none, had higher viral loads at both time points.
We have conducted a comprehensive analysis of PvMsp-5 by sequencing the entire gene of four parasite populations from northwestern Thailand (n = 73), southern Thailand (n = 53), Indonesia (n = 25) and Brazil (n = 24), and five isolates from other endemic areas. Results reveal that exon I exhibits a significantly higher level of nucleotide diversity at both synonymous and nonsynonymous sites than exon II (p < 0.01).
In western Cambodia, malaria parasites clear slowly from the blood after treatment with artemisinin derivatives, but it is unclear whether this results from parasite, host, or other factors specific to this population.
Levels of IgG antibody to pregnancy‐specific VSAs decrease during receipt of IPTp. Antibody levels in early pregnancy did not predict clinical outcome. IPTp and decreasing malaria prevalence pose challenges for the evaluation of novel interventions for malaria during pregnancy.
This review will describe the effect of classical antibacterial agents against malaria parasites and the use of some of these compounds in clinical settings.
Malaria control programs and their donor partners across the endemic world should urgently revitalize efforts to characterize and track potentially resistant parasites, especially where they are investing heavily in rolling out access to ACTs.