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Scientific Articles

Open Access| Malaria vectors of Timor-Leste

February 9, 2010 - 14:00 -- Ingeborg van Schayk
Author(s): 
Robert D Cooper, Michael D Edstein, Stephen P Frances, Nigel W Beebe
Reference: 
Malaria Journal 2010, 9:40 (2 February 2010)

The aim of this study is to accurately identify the Anopheles fauna of Timor-Leste using these techniques.

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Open Access | Plasmodium yoelii-Infected A. stephensi Inefficiently Transmit Malaria Compared to Intravenous Route

February 9, 2010 - 13:32 -- Ingeborg van Schayk
Author(s): 
Solomon Conteh, Rana Chattopadhyay, Charles Anderson, Stephen L. Hoffman
Reference: 
PLoS ONE 5(1): e8947

Such data may have implications for determining the best route and dose of administration to humans of our attenuated P. falciparum sporozoite vaccine, the scientific basis of which is immunity by bites from irradiated infected mosquitoes, and suggest that the challenge is to develop a method of administration that approximates IV inoculation, not one that mimics mosquito bite.

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Open Access | Evaluating Different Dimensions of Programme Effectiveness for Private Medicine Retailer Malaria Control Interventions in Kenya

February 9, 2010 - 13:20 -- Ingeborg van Schayk
Author(s): 
Timothy O. Abuya, Greg Fegan, Abdinasir A. Amin, Willis S. Akhwale, Abdisalan M. Noor, Robert W. Snow, Vicki Marsh
Reference: 
PLoS ONE 5(1): e8937

This study presents evaluation findings of two different programs implemented at moderate scale targeting PMRs for malaria control in the Kisii and Kwale districts of Kenya.

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Open Access | Age-Patterns of Malaria Vary with Severity, Transmission Intensity and Seasonality in Sub-Saharan Africa: A Systematic Review and Pooled Analysis

February 9, 2010 - 12:47 -- Ingeborg van Schayk
Author(s): 
Ilona Carneiro, Arantxa Roca-Feltrer, Jamie T. Griffin, Lucy Smith, Marcel Tanner, Joanna Armstrong Schellenberg, Brian Greenwood, David Schellenberg
Reference: 
PLoS ONE 5(2): e8988

We have, therefore, undertaken a pooled analysis of existing data from multiple sites to enable a comprehensive overview of the age-patterns of malaria outcomes under different epidemiological conditions in sub-Saharan Africa.

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Open Access | Loss of balancing selection in the beta S globin locus

February 7, 2010 - 14:10 -- Ingeborg van Schayk
Author(s): 
Niven A Salih, Ayman A Hussain, Ibrahim A Elmugtaba, Abeir M Elzein, Ibrahim M Elhassan, Eltahir AG Khalil, Hani B Ishag, Hiba S Mohamed, Dominic Kwiatkowski and Muntaser E Ibrahim
Reference: 
BMC Medical Genetics 2010, 11:21

Probably the best example of the rise and maintenance of balancing selection as an evolutionary trend is the role of S-haemoglobin (HbS - rs334) in protecting from malaria. Yet, the dynamics of such a process remains poorly understood, particularly in relation to different malaria transmission rates and the genetic background of the affected populations.

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An assessment of Lot Quality Assurance Sampling to evaluate malaria outcome indicators: extending malaria indicator surveys

February 7, 2010 - 13:57 -- Ingeborg van Schayk
Author(s): 
Caitlin Biedron, Marcello Pagano, Bethany L Hedt, Albert Kilian, Amy Ratcliffe, Samuel Mabunda, and Joseph J Valadez
Reference: 
Int. J. Epidemiol. 2010 39: 72-79

This article demonstrates the feasibility of integrating LQAS into multistage cluster sampling surveys and using these results to support a comprehensive national, regional and local programme M&E system.

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Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

February 5, 2010 - 17:05 -- Ingeborg van Schayk
Author(s): 
Spencer C. Maughan, Maciej Pasternak, Christopher S. Cobbett, et al.
Reference: 
PNAS February 2, 2010 vol. 107 no. 5 2331-2336C

We conclude that these transporters play a significant role in regulating GSH levels and the redox potential of the cytosol.

Open Access | Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion

February 5, 2010 - 16:59 -- Ingeborg van Schayk
Author(s): 
Lubin Jiang, María José López-Barragán, Hongying Jiang, Jianbing Mu, Deepak Gaur, Keji Zhao, Gary Felsenfeld, and Louis H. Miller
Reference: 
PNAS February 2, 2010 vol. 107 no. 5 2224-2229

Our data indicate that the failure of Dd2 to express the sialic acid-independent invasion receptor gene RH4 is associated with the epigenetic silencing mark H3K9 trimethylation present throughout the cycle.

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Assessment of the Impact of Climate Shifts on Malaria Transmission in the Sahel

February 5, 2010 - 16:50 -- Ingeborg van Schayk
Author(s): 
Arne Bomblies and Elfatih A. B. Eltahir
Reference: 
EcoHealth, Online First

We seek to evaluate the impact of hypothetical climate change scenarios on malaria transmission in the Sahel by using a novel mechanistic, high spatial- and temporal-resolution coupled hydrology and agent-based entomology model.

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Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

February 5, 2010 - 16:46 -- Ingeborg van Schayk
Author(s): 
Devdutt Chaturvedi, Abhishek Goswami, Partha Pratim Saikia, Nabin C. Barua and Paruchuri G. Rao
Reference: 
Chem. Soc. Rev., 2010, 39, 435 - 454

It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

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