Duffy binding protein (DBP), a leading malaria vaccine candidate, plays a critical role in Plasmodium vivax erythrocyte invasion. Sixty-eight of 366 (18.6%) subjects had IgG anti-DBP antibodies by enzyme-linked immunosorbent assay (ELISA) in a community-based cross-sectional survey in the Brazilian Amazon Basin.
Larviciding to control malaria was assessed in rural areas with extensive seasonal flooding. Larval and adult mosquitoes and malaria incidence were surveyed routinely in four 100-km2 areas either side of the Gambia River.
One thing is clear: Any form of compromise in terms of tool implementation, (area-wide) coverage or stringency in campaign execution will hold the recipe for failure.
Cyclooxygenase (COX) and lipoxygenase (LOX), which convert fatty acids to prostaglandins and leukotrienes, play important roles in pregnancy and foetal development. The role of COX during PM was questioned by quantifying at delivery COX-1, COX-2, 15-LOX, and IL-10 expression in two groups of malaria infected and uninfected placenta.
The study indicates that chlorpyrifos methyl outperformed DDT and lambdacyhalothrin. In IRS campaigns, it should provode improved levels of transmission control compared to conventional formulations of DDT or pyrethroids, always assuming that the product is available for such use.
The authors discuss the compliance associated with a three-day AS-MQ regimen following a recent change in the treatment guidelines for uncomplicated falciparum malaria in Thailand. The patient data are supported by whole blood/plasma drug levels. In malaria treatment compliance remains a major factor determining effectiveness.
Original approach aimed at improving malaria diagnostic accuracy in sub-Saharan Africa by enhancing community involvement in a Maasai district.
Interesting paper on the determinants of prophylaxis among French soldiers during missions in Africa.
The aim of this study is to accurately identify the Anopheles fauna of Timor-Leste using these techniques.
Such data may have implications for determining the best route and dose of administration to humans of our attenuated P. falciparum sporozoite vaccine, the scientific basis of which is immunity by bites from irradiated infected mosquitoes, and suggest that the challenge is to develop a method of administration that approximates IV inoculation, not one that mimics mosquito bite.