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Scientific Articles

Open Access | Transglutaminase-Mediated Semen Coagulation Controls Sperm Storage in the Malaria Mosquito

December 24, 2009 - 12:44 -- Ingeborg van Schayk
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Author(s): 
Rogers DW, Baldini F, Battaglia F, Panico M, Dell A, et al.
Reference: 
PLoS Biol 7(12): e1000272

Our data show that the mating plug is an important feature of An. gambiae reproduction, and reinforce the notion that a deeper understanding of mosquito reproductive biology can aid efforts to eradicate these disease vectors.

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Open Access | Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects

December 23, 2009 - 21:47 -- Ingeborg van Schayk
Author(s): 
Beesan Tan, Himanshu Naik, In-Jin Jang, Kyung-Sang Yu, Lee E Kirsch, Chang-Sik Shin, J Carl Craft, Lawrence Fleckenstein
Reference: 
Malaria Journal 2009, 8:304 (18 December 2009)

The population pharmacokinetics of artesunate (AS) and its active metabolite dihydroartemisinin (DHA) were studied in healthy subjects receiving single- or multiple-dosing of AS orally either in combination with pyronaridine (PYR) or as a monotherapy with or without food.

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Open Access | Chloroquine reduces arylsulphatase B activity and increases chondroitin 4-sulphate: implications for mechanisms of action and resistance

December 23, 2009 - 21:42 -- Ingeborg van Schayk
Author(s): 
Sumit Bhattacharyya, Kemal Solakyildirim, Zhenqing Zhang, Robert J Linhardt, Joanne K Tobacman
Reference: 
Malaria Journal 2009, 8:303 (17 December 2009)

If chloroquine reduced ASB activity, leading to increased chondroitin-4-sulphation, it was hypothesized that the anti-malarial mechanism of chloroquine might derive, at least in part, from suppression of ASB.

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Open Access | Cultured skin microbiota attracts malaria mosquitoes

December 23, 2009 - 21:35 -- Ingeborg van Schayk
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Author(s): 
Niels O Verhulst, Hans Beijleveld, Bart GJ Knols, Willem Takken, Gosse Schraa, Harro J Bouwmeester, Renate C Smallegange
Reference: 
Malaria Journal 2009, 8:302 (17 December 2009)

A study is presented in which the production and constituency of volatile organic compounds (VOCs) by human skin microbiota is examined and the behavioural responses of An. gambiae to VOCs from skin microbiota are investigated.

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Open Access | Treatment-seeking for febrile illness in north-east India: an epidemiological study in the malaria endemic zone

December 23, 2009 - 21:29 -- Ingeborg van Schayk
Author(s): 
Himanshu K Chaturvedi, Jagadish Mahanta, Arvind Pandey
Reference: 
Malaria Journal 2009, 8:301 (17 December 2009)

This paper studies the determinants of utilization of health care services, especially for treatment of febrile illness in the malaria endemic area of north-east India.

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Open Access | Evidence of decline of malaria in the general hospital of Libreville, Gabon from 2000 to 2008

December 23, 2009 - 21:25 -- Ingeborg van Schayk
Author(s): 
Marielle Karine Bouyou-Akotet, Denise Patricia Mawili-Mboumba, Maryvonne Kombila et al.
Reference: 
Malaria Journal 2009, 8:300 (17 December 2009)

The trend in malaria morbidity was evaluated among febrile children before and after their implementation in Libreville, the capital city of Gabon.

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Open Access | Insecticide resistance in Anopheles gambiae: data from the first year of a multi-country study highlight the extent of the problem

December 23, 2009 - 21:16 -- Ingeborg van Schayk
Author(s): 
Hilary Ranson, Hiba Abdallah, Athanase Badolo, Wamdaogo Moussa Guelbeogo, Clement Kerah-Hinzoumbe, Elise Yangalbe-Kalnone, N'Fale Sagnon, Frederic Simard, Maureen Coetzee
Reference: 
Malaria Journal 2009, 8:299 (17 December 2009)

The results of this study highlight the importance of standardized longitudinal insecticide resistance monitoring and the urgent need for studies to monitor the impact of this resistance on malaria vector control activities.

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Open Access | A cluster randomized controlled cross-over bed net acceptability and preference trial in Solomon Islands: community participation in shaping policy for malaria elimination

December 23, 2009 - 11:47 -- Ingeborg van Schayk
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Reference: 
Jo-An Atkinson, Albino Bobogare, Andrew Vallely, Leonard Boaz, Gerard Kelly, William Basifiri, Simon Forsyth, Peter Baker, Bridget Appleyard, Hilson Toaliu, Gail Williams

This research was conducted to inform LLIN procurement as part of the national malaria control and elimination programme in SI.

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Open Access | Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children

December 23, 2009 - 11:35 -- Ingeborg van Schayk
Author(s): 
Akintunde Sowunmi, Oluchi O Nkogho, Titilope M Okuboyejo, Grace O Gbotosho, Christian T Happi, Elsie O Adewoye
Reference: 
Malaria Journal 2009, 8:297 (16 December 2009)

Addition of artesunate to mefloquine significantly modified the emergence, clearance, and densities of gametocytes and has short-lived, but significant, sex ratio modifying effects in children from this endemic area.

Open Access | Modeling the risk of malaria for travellers to areas with stable malaria transmission

December 23, 2009 - 11:26 -- Ingeborg van Schayk
Author(s): 
Eduardo Massad, Ronald H Behrens, Marcelo N Burattini, Francisco AB Coutinho
Reference: 
Malaria Journal 2009, 8:296 (16 December 2009)

Risk estimates based on mathematical modeling based on accurate data can be a valuable tool in assessing risk/benefits and cost/benefits when deciding on the value of interventions for travellers to malaria endemic regions.

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