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Scientific Articles

Open Access : Methodology: Flow cytometry for the evaluation of anti-plasmodial activity of drugs on Plasmodium falciparum gametocytes

February 17, 2010 - 19:52 -- Ingeborg van Schayk
Author(s): 
Severine Chevalley, Agnes Coste, Alexandrine Lopez, Bernard Pipy, Alexis Valentin
Reference: 
Malaria Journal 2010, 9:49 (11 February 2010)

In the current study, flow cytometry has been used to study the effect of established anti-malarial drugs against sexual stages obtained from W2 strain of Plasmodium falciparum.

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Editorial: King Tutankhamun, Modern Medical Science, and the Expanding Boundaries of Historical Inquiry

February 17, 2010 - 08:56 -- Ingeborg van Schayk
Author(s): 
Howard Markel
Reference: 
JAMA. 2010;303(7):667-668

Indeed, this finding constitutes the oldest genetic proof of malaria in well-dated mummies.

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Ancestry and Pathology in King Tutankhamun's Family

February 17, 2010 - 08:48 -- Ingeborg van Schayk
Author(s): 
Zahi Hawass, Yehia Z. Gad, Carsten M. Pusch et al.
Reference: 
JAMA, February 17, 2010; 303: 638 - 647

These results suggest avascular bone necrosis in conjunction with the malarial infection as the most likely cause of death in Tutankhamun. Walking impairment and malarial disease sustained by Tutankhamun is supported by the discovery of canes and an afterlife pharmacy in his tomb.

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Open Access | Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania

February 16, 2010 - 14:02 -- Ingeborg van Schayk
Author(s): 
Abdunoor M Kabanywanyi, Christian Lengeler, Prudensiana Kasim, Said King'eng'ena, Raymond Schlienger, Nathan Mulure, Blaise Genton
Reference: 
Malaria Journal 2010, 9:48 (11 February 2010)

Adherence to the dosing regimen and timing of AL administration was very good.

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Open Access | The influence of the Gilgel-Gibe hydroelectric dam in Ethiopia on caregivers' knowledge, perceptions and health-seeking behaviour towards childhood malaria

February 16, 2010 - 13:56 -- Ingeborg van Schayk
Author(s): 
Delenasaw Yewhalaw, Wondwossen Kassahun, Kifle Woldemichael, Kora Tushune, Moranker Sudaker, Daniel Kaba, Luc Duchateau, Wim Van Bortel, Niko Speybroeck
Reference: 
Malaria Journal 2010, 9:47 (11 February 2010)

Mothers' or caregivers' ability to recognize childhood malaria-related morbidity is crucial as knowledge, attitudes and health seeking behavior of caregivers towards childhood malaria could influence response to signs of the disease.

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Open Access : Suppressive and additive effects in protection mediated by combinations of monoclonal antibodies specific for merozoite surface protein 1 of Plasmodium yoelii

February 16, 2010 - 13:33 -- Ingeborg van Schayk
Author(s): 
Irosoki Eslava, Gilberto Payares, Beatriz M Pernia, Anthony A Holder, Lilian M Spencer
Reference: 
Malaria Journal 2010, 9:46 (10 February 2010)

These results suggest that a combination of protective antibodies with either the same or different isotypes can produce either an additive or a suppressive effect in passive immunization. This phenomenon may be important in better understanding immunity in this experimental mouse model of malaria.

Is It Time to Change Guidelines for Iron Supplementation in Malarial Areas?

February 16, 2010 - 12:58 -- Ingeborg van Schayk
Author(s): 
Parminder S. Suchdev, Ira L. Leeds, Deborah A. McFarland, and Rafael Flores
Reference: 
J. Nutr. published 10 February 2010, 10.3945/jn.109.118638

 No abstract available

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Open Access | A Plasmodium falciparum Strain Expressing GFP throughout the Parasite's Life-Cycle

February 16, 2010 - 11:11 -- Ingeborg van Schayk
Author(s): 
Arthur M. Talman, Andrew M. Blagborough, Robert E. Sinden
Reference: 
PLoS ONE 5(2): e9156

The development of 3D7HT-GFP will permit a deeper understanding of the biology of parasite-host vector interactions, and facilitate the development of high-throughput malaria transmission assays and thus aid development of new intervention strategies against both parasite and mosquito.

Open Access | Structural Determination of Functional Units of the Nucleotide Binding Domain (NBD94) of the Reticulocyte Binding Protein Py235 of Plasmodium yoelii

February 16, 2010 - 11:01 -- Ingeborg van Schayk
Author(s): 
Ardina Grüber, Malathy S. S. Manimekalai, Asha M. Balakrishna, Cornelia Hunke, Jeyaraman Jeyakanthan, Peter R. Preiser, Gerhard Grüber
Reference: 
PLoS ONE 5(2): e9146

These structures give the first insight into how nucleotide binding impacts on the overall structure of RH and demonstrates the potential use of this region as a novel drug target.

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Open Access | Safety and Immunogenicity of an AMA1 Malaria Vaccine in Malian Children: Results of a Phase 1 Randomized Controlled Trial

February 16, 2010 - 10:56 -- Ingeborg van Schayk
Author(s): 
Thera MA, Doumbo OK, Coulibaly D, Laurens MB, Kone AK, et al.
Reference: 
PLoS ONE 5(2): e9041

The FMP2.1/AS02A vaccine had a good safety profile, was well-tolerated, and induced high and sustained antibody levels in malaria-exposed children. This malaria vaccine is being evaluated in a Phase 2 efficacy trial in children at this site.

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