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Scientific Articles

Open Access | Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

April 13, 2010 - 09:15 -- Kabogo Ndegwa
Author(s): 
Melissa R. van Dijk, Ben C. L. van Schaijk Chris J. Janse, et al
Reference: 
PLoS Pathog 6(4): e1000853

 

The implications of low levels of fertilisation that exist even in the absence of these proteins, indicating alternative pathways of fertilisation, as well as positive selection acting on these proteins, are discussed in the context of targeting these proteins as transmission blocking vaccine candidates.

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Spatio-Temporal Patterns in kdr Frequency in Permethrin and DDT Resistant Anopheles gambiae s.s. from Uganda

April 13, 2010 - 09:11 -- Patrick Sampao
Author(s): 
Katrijn Verhaeghen, Wim Van Bortel, Patricia Roelants, Paul Edward Okello, Ambrose Talisuna, AND Marc Coosemans
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82: 4, pp. 566-573

In the dry season, the kdr frequency was significantly higher in Plasmodium falciparum-infected mosquitoes, indicating that mosquitoes bearing a kdr mutation have a better adult survival, hence a higher likelihood of becoming infectious.

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Transmission and Cross-Mating of High-Level Resistance Plasmodium falciparum Dihydrofolate Reductase Haplotypes in The Gambia

April 13, 2010 - 09:05 -- Patrick Sampao
Author(s): 
Amani Kheir, Davis Nwakanma, Aisha Al-Gazali, Yagut Akbarova, Salma Al-Saai, Göte Swedberg, AND Hamza A. Babiker
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 535-541

Similarities were seen between pfg377 and MSP-1 alleles in children and mosquitoes and evidence of cross-mating between different parasite genotypes was seen in some infected mosquitoes, reflecting high transmission success of existing clones.

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Treatment with Coartem (Artemether-Lumefantrine) in Papua New Guinea

April 13, 2010 - 08:58 -- Patrick Sampao
Author(s): 
Sonja Schoepflin, Enmoore Lin, Benson Kiniboro, Jeana T. DaRe, Rajeev K. Mehlotra, Peter A. Zimmerman, Ivo Mueller, AND Ingrid Felger
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 529-534

After excluding genetic host factors by genotyping potentially relevant cytochrome P450 loci, the high number of treatment failures in our study is best explained by poor adherence to complex dosing regimens in combination with insufficient fat supplementation, which are both crucial parameters for the outcome of Coartem treatment.

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Brief report: Emergence of New Alleles of the MSP-3{alpha} Gene in Plasmodium vivax Isolates from Korea

April 13, 2010 - 08:51 -- Patrick Sampao
Author(s): 
Deok Hwa N., Jun Seo O., et al.
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 522-524

Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006–2007 accounted for nearly 50% (25/51) of the sampled isolates.

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A Comparison of Two Short-Course Primaquine Regimens for the Treatment and Radical Cure of Plasmodium vivax Malaria in Thailand

April 13, 2010 - 08:40 -- Patrick Sampao
Author(s): 
Sasithon Pukrittayakamee, Mallika Imwong, Kesinee Chotivanich, Pratap Singhasivanon, Nicholas P. J. Day, AND Nicholas J. White
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 542-547

These data suggest that the dose-response relationships for primaquine's asexual stage and hypnozoitocidal activities in-vivo are different.

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TLR9 Polymorphisms Are Associated with Altered IFN-{gamma} Levels in Children with Cerebral Malaria

April 13, 2010 - 08:32 -- Patrick Sampao
Author(s): 
Nadia A. Sam-A., Jennifer A. G., et al
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 548-555

We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection.

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Case report: Severe Congenital Malaria Acquired in utero

April 13, 2010 - 08:18 -- Patrick Sampao
Author(s): 
Jeanne R. P., Afdal H., et al.,
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82: 4, 2010, pp. 563-565

We report symptomatic congenital malaria presenting as a neonatal sepsis syndrome.

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Syndromic Diagnosis of Malaria in Rural Sierra Leone and Proposed Additions to the National Integrated Management of Childhood Illness Guidelines for Fever

April 13, 2010 - 08:08 -- Patrick Sampao
Author(s): 
Obinna N. Nnedu, Bryan Rimel, Carey Terry, Heidi Jalloh-Vos, Brima Baryon, AND Daniel G. Bausch
Reference: 
American Journal of Tropical Medicine Hygiene, Vol 82 : 4, 2010, pp. 525-528

In a multivariate analysis, splenomegaly (P = 0.04) was the only clinical sign significantly associated with laboratory-confirmed malaria, and sleeping under a bed net was protective (P = 0.05). Our findings show that clinical malaria is diagnosed relatively accurately in rural Sierra Leone.

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Malaria Parasitemia and CD4 T Cell Count, Viral Load, and Adverse HIV Outcomes Among HIV-Infected Pregnant Women in Tanzania

April 13, 2010 - 07:40 -- Patrick Sampao
Author(s): 
Molly F. Franke, Donna Spiegelman, Amara Ezeamama, Said Aboud, Gernard I. Msamanga, Saurabh Mehta, AND Wafaie W. Fawzi
Reference: 
American Journal of Tropical Medicine Hygien, Vol 82 : 4, 2010, pp. 556-562

Parasitemia level was nonlinearly associated with viral load at baseline and among measurements taken > 90 days post-baseline; women with low baseline parasitemia, versus none, had higher viral loads at both time points.

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