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Scientific Articles

Open Access | Prime-Boost Immunization with Adenoviral and Modified Vaccinia Virus Ankara Vectors Enhances the Durability and Polyfunctionality of Protective Malaria CD8+ T-Cell Responses

January 10, 2010 - 14:29 -- Ingeborg van Schayk
Author(s): 
Arturo Reyes-Sandoval, Tamara Berthoud, Nicola Alder, Loredana Siani, Sarah C. Gilbert, Alfredo Nicosia, Stefano Colloca, Riccardo Cortese, and Adrian V. S. Hill
Reference: 
Infect. Immun. 2010;78 145-153 Open Access

These data highlight the ability of optimized viral vector prime-boost regimens to generate more protective and sustained CD8+ T-cell responses, and our results encourage a more nuanced assessment of the importance of inducing polyfunctional CD8+ T cells by vaccination.

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A Novel Functional Variant in the Stem Cell Growth Factor Promoter Protects against Severe Malarial Anemia

January 10, 2010 - 14:27 -- Ingeborg van Schayk
Author(s): 
Collins Ouma, Christopher C. Keller, Gregory C. Davenport, Tom Were, Stephen Konah, Michael F. Otieno, James B. Hittner, John M. Vulule, Jeremy Martinson, John M. Ong'echa, Robert E. Ferrell, and Douglas J. Perkins
Reference: 
Infect. Immun. 2010;78 453-460

The results presented here demonstrate that homozygous T at –539 in the SCGF promoter is associated with elevated SCGF production, enhanced erythropoiesis, and protection against the development of SMA in children with falciparum malaria.

Open Access | The Plasmodium falciparum merozoite surface protein-1 19kD antibody response in the Peruvian Amazon predominantly targets the non-allele specific, shared sites of this antigen

January 7, 2010 - 13:45 -- Ingeborg van Schayk
Author(s): 
Patrick L Sutton, Eva H Clark, Claudia Silva, OraLee H Branch
Reference: 
Malaria Journal 2010, 9:3 (4 January 2010)

Here, the potential for allele-specific polymorphisms in this population is investigated, and the allele-specificity of antibody responses to PfMSP119kD are determined.

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Open Access | Plasmodium infection and its risk factors in eastern Uganda

January 7, 2010 - 13:40 -- Ingeborg van Schayk
Author(s): 
Rachel L Pullan, Hasifa Bikirwa, Sarah G Staedke, Robert W Snow, Simon Brooker
Reference: 
Malaria Journal 2010, 9:2 (4 January 2010)

These findings demonstrate that mosquito net usage remains inadequate and is strongly associated with risk of malaria among school-aged children. Infection risk amongst adults is influenced by proximity to potential mosquito breeding grounds.

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Open Access | Genetic diversity among Plasmodium falciparum field isolates in Pakistan measured with PCR genotyping of the merozoite surface protein 1 and 2

January 7, 2010 - 13:36 -- Ingeborg van Schayk
Author(s): 
Najia K Ghanchi, Andreas Martensson, Johan Ursing, Sana Jafri, Sandor Bereczky, Rabia Hussain, Mohammad A Beg
Reference: 
Malaria Journal 2010, 9:1 (1 January 2010)

This is the first report on molecular characterization of P. falciparum field isolates in Pakistan with regards to multiplicity of infection.

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Open Access | Determining and addressing obstacles to the effective use of long-lasting insecticide-impregnated nets in rural Tanzania

January 7, 2010 - 13:31 -- Ingeborg van Schayk
Author(s): 
Maria Widmar, Courtney J Nagel, Deborah Y Ho, Peter W Benziger, Nils Hennig
Reference: 
Malaria Journal 2009, 8:315 (31 December 2009)

The objective of this project was to achieve high, sustainable levels of net coverage in a village in rural Tanzania by combining free distribution of long-lasting insecticide-impregnated nets (LLINs) with community-tailored education.

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Open Access | Design and pre-clinical profiling of a Plasmodium falciparum MSP-3 derived component for a multi-valent virosomal malaria vaccine

January 7, 2010 - 13:27 -- Ingeborg van Schayk
Author(s): 
Marco Tamborrini, Markus S Mueller, Sabine A Stoffel, Nicole Westerfeld, Denise Vogel, Francesca Boato, Rinaldo Zurbriggen, John A Robinson, Gerd Pluschke
Reference: 
Malaria Journal 2009, 8:314 (30 December 2009)

These results reconfirm the suitability of IRIVs as a carrier/adjuvant system for the induction of strong humoral immune responses against a wide range of synthetic peptide antigens.

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Open Access | Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin combination therapy

January 7, 2010 - 13:22 -- Ingeborg van Schayk
Author(s): 
Grace O Gbotosho, Christian T Happi, Abideen Ganiyu, Olumide A Ogundahunsi, Akin Sowunmi, Ayoade M Oduola
Reference: 
Malaria Journal 2009, 8:313 (30 December 2009)

The results from this study describe a lack of adherence to national treatment guidelines, especially in the private sector, and a relationship between prescription practices and dissemination of drug resistant falciparum malaria.

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Open Access | Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data

January 7, 2010 - 13:18 -- Ingeborg van Schayk
Author(s): 
Vasee S Moorthy, W Ripley Ballou
Reference: 
Malaria Journal 2009, 8:312 (30 December 2009)

In this article, what is known about mechanisms involved in partial protection against malaria induced by RTS,S is reviewed.

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Open Access | Achieving high coverage of larval-stage mosquito surveillance: challenges for a community-based mosquito control programme in urban Dar es Salaam, Tanzania

January 7, 2010 - 13:14 -- Ingeborg van Schayk
Author(s): 
Prosper P Chaki, Nicodem J Govella, Bryson Shoo, Abdullah Hemed, Marcel Tanner, Ulrike Fillinger, Gerry F Killeen
Reference: 
Malaria Journal 2009, 8:311 (30 December 2009)

Accessibility of habitats in urban settings presents a major challenge because the majority of compounds are fenced for security reasons.

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