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Scientific Articles

Case Report: Symmetrical peripheral gangrene in childhood falciparum malaria

February 26, 2010 - 12:36 -- Kabogo Ndegwa
Author(s): 
Rajoo Thapa, Apurba Ghosh, Debkrishna Mallick, Biswajit Biswas
Reference: 
International Journal of Dermatology, Volume 49, Issue 3, March 2010, Pages: 303-305

No Abstract Available

Short Communication: Antiplasmodial activity of isolated compounds from Carpesium divaricatum

February 26, 2010 - 12:34 -- Kabogo Ndegwa
Author(s): 
Ill-Min Chung, Su-Hyun Seo, Eun-Young Kang, Won-Hwan Park, Sun-Dong Park, Hyung-In Moon
Reference: 
Phytotherapy Research Volume 24, Issue 3, March 2010, Pages: 451-453

The present paper deals with the isolation and identification of antiplasmodial compounds from C. divaricatum in Carpesium spp. This is the first report on the antiplasmodial activity of the compounds from C. divaricatum.

Short Communication: Antiplasmodial and cytotoxic activity of khellactone derivatives from Angelica purpuraefolia chung

February 26, 2010 - 12:33 -- Kabogo Ndegwa
Author(s): 
Ill-Min Chung, Bimal Kumar Ghimire, Eun-Young Kang, Hyung-In Moon
Reference: 
Phytotherapy Research, Volume 24, Issue 3, March 2010, Pages: 469-471

The methanolic extract of the rhizomes parts of Agelica purpuraefolia was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method.

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General Chemistry: Pyrrolidine Derivatives as Plasmepsin Inhibitors: Binding Mode Analysis Assisted by Molecular Dynamics Simulations of a Highly Flexible Protein

February 26, 2010 - 11:52 -- Kabogo Ndegwa
Author(s): 
Torsten Luksch, Andreas Blum, Nina Klee, Wibke E. Diederich, Christoph A. Sotriffer, Gerhard Klebe
Reference: 
ChemMedChem, Volume 5, Issue 3, March 1, 2010, Pages: 443-454

Plasmepsins II (EC number: 3.4.23.39) and IV (EC number: 3.4.23.B14) are aspartic proteases present in the food vacuole of the malaria parasite Plasmodium falciparum and are involved in host hemoglobin degradation.

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Open Access : Zoology: State-dependent attacks in a mosquito

February 26, 2010 - 11:49 -- Kabogo Ndegwa
Author(s): 
Bernard D. Roitberg, Sigrid Keiser, Thomas Hoffmeister
Reference: 
Physiological Entomology, Volume 35, Issue 1, March 2010, Pages: 46-51

Because both parameters are likely to depend on the size and energetic state of adult mosquitoes, the present study investigates the effects of body size and energy state on attack behaviours in the malaria mosquito, Anopheles gambiae.

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Letter: Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

February 26, 2010 - 11:43 -- Kabogo Ndegwa
Author(s): 
Jianbing Mu, Rachel A Myers, Hongying Jiang, Shengfa Liu, Stacy Ricklefs, Michael Waisberg, Kesinee Chotivanich, Polrat Wilairatana, Srivicha Krudsood, Nicholas J White, et al.
Reference: 
Nature Genetics Volume: 42, Pages: 268–271, 2010

Here we report the first Plasmodium GWAS, which included 189 culture-adapted P. falciparum parasites genotyped using a custom-built Affymetrix molecular inversion probe 3K malaria panel array with a coverage of ~1 SNP per 7 kb.

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Limited genetic polymorphism of the Plasmodium vivax low molecular weight rhoptry protein complex in the Colombian population

February 26, 2010 - 11:37 -- Kabogo Ndegwa
Author(s): 
Diego Garzon-Ospina, Liza Romero-Murillo, Manuel A. Patarroyo
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 2, March 2010, Pages 261-267

Our results support the inclusion of PvRAP-1 and PvRAP-2 in the design of an antimalarial subunit-based vaccine against P. vivax, which would avoid inducing allele-specific immunity.

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Evolutionary dynamics of the immunodominant repeats of the Plasmodium vivax malaria-vaccine candidate circumsporozoite protein (CSP)

February 26, 2010 - 11:35 -- Kabogo Ndegwa
Author(s): 
Aarti Patil, Pamela Orjuela-Sánchez, Mônica da Silva-Nunes, Marcelo U. Ferreira
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 2, March 2010, Pages 298-303

To determine whether rearrangements of repeat motifs during mitotic DNA replication of parasites create significant CSP diversity under conditions of low effective meiotic recombination rates, we examined csp alleles from sympatric P. vivax isolates systematically sampled from an area of low malaria endemicity in Brazil over a period of 14 months.

Gene polymorphisms in angiotensin I converting enzyme (ACE I/D) and angiotensin II converting enzyme (ACE2 C → T) protect against cerebral malaria in Indian adults

February 26, 2010 - 11:32 -- Kabogo Ndegwa
Author(s): 
Gunanidhi Dhangadamajhi, Biranchi N. Mohapatra, Shantanu K. Kar, Manoranjan Ranjit
Reference: 
Infection, Genetics and Evolution, Volume 10, Issue 2, March 2010, Pages 337-341

To explore the hypothesis that angiotensin II may play a role in the susceptibility to cerebral malaria (CM), we performed a genetic association study of malaria patients in Orissa, India analyzing three SNPs (ACE2 C → T, iNOS C → T, eNOS Glu → Asp) and two I/D polymorphisms (ACE I/D and IL-4 B1/B2).

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