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Scientific Articles

Open Access | Mapping Epitopes of the Plasmodium vivax Duffy Binding Protein with Naturally Acquired Inhibitory Antibodies

February 26, 2010 - 17:28 -- Ingeborg van Schayk
Author(s): 
Patchanee Chootong, Francis B. Ntumngia, Kelley M. VanBuskirk, Jia Xainli, Jennifer L. Cole-Tobian, Christopher O. Campbell, Tresa S. Fraser, Christopher L. King, and John H. Adams
Reference: 
Infect. Immun. 2010;78 1089-1095

These results represent an important advance in our understanding of part of blood-stage immunity to P. vivax and some of the specific targets for vaccine-elicited antibody protection.

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Suppression of Plasmodium cynomolgi in Rhesus Macaques by Coinfection with Babesia microti

February 26, 2010 - 17:20 -- Ingeborg van Schayk
Author(s): 
Leonie M. van Duivenvoorde, Annemarie Voorberg-van der Wel, Nicole M. van der Werff, Gerco Braskamp, Edmond J. Remarque, Ivanela Kondova, Clemens H. M. Kocken, and Alan W. Thomas
Reference: 
Infect. Immun. 2010;78 1032-1039

We recently reported that a rhesus macaque that was chronically infected with Babesia microti was able to control infection with Plasmodium cynomolgi (a parasite of macaques with characteristics very similar to those of Plasmodium vivax) better than naïve monkeys. 

Open Access |Differential Recognition of P. falciparum VAR2CSA Domains by Naturally Acquired Antibodies in Pregnant Women from a Malaria Endemic Area

February 26, 2010 - 17:15 -- Ingeborg van Schayk
Author(s): 
Kim J. M. Brolin, Kristina E. M. Persson, Mats Wahlgren, Stephen J. Rogerson, Qijun Chen
Reference: 
PLoS ONE 5(2): e9230

Understanding the characteristics of antibody response against VAR2CSA is undoubtedly imperative in order to design a functional and efficient vaccine against PAM.

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Male accessory gland proteins induce female monogamy in anopheline mosquitoes

February 26, 2010 - 16:59 -- Ingeborg van Schayk
Author(s): 
B. Shutt, L. Stables, F. Aboagye-Antwi, J. Moran, F. Tripet
Reference: 
Medical and Veterinary Entomology Volume 24 Issue 1, Pages 91 - 94

Here we confirm the function of MAG secretions in anophelines experimentally by showing that intra-thoracic injections in Anopheles stephensi Liston and in the M and S molecular forms of An. gambiae s.s. result in the expected female monogamy.

Open Access | Impact of indoor residual spray with synthetic pyrethroid in Gandhinagar district, Gujarat

February 26, 2010 - 16:16 -- Ingeborg van Schayk
Author(s): 
Mamta Dattani, PB Prajapati, Dinkar Raval
Reference: 
Indian J Community Med 2009;34:288-92

IRS, it still has a major role in the control of malaria if implemented with proper supervision, better coverage and community participation.

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Distinct Subcellular Localization in the Cytosol and Apicoplast, Unexpected Dimerization, and Inhibition of Plasmodium falciparum Glyoxalases

February 26, 2010 - 16:04 -- Ingeborg van Schayk
Author(s): 
Miriam Urscher, Jude M. Przyborski, Masaya Imoto and Marcel Deponte
Reference: 
Molecular Microbiology, Early View

The ubiquitous glyoxalase system removes methylglyoxal as a harmful by-product of glycolysis. Because malaria parasites have drastically increased glycolytic fluxes, they could be highly susceptible to the inhibition of this detoxification pathway.

Open Access | Willingness to pay for rapid diagnostic tests for the diagnosis and treatment of malaria in southeast Nigeria: ex post and ex ante

February 26, 2010 - 15:52 -- Ingeborg van Schayk
Author(s): 
Benjamin SC Uzochukwu, Obinna E Onwujekwe, Nkoli P Uguru, Maduka D Ughasoro and Ogochukwu P Ezeoke
Reference: 
International Journal for Equity in Health 2010, 9:1

The introduction of rapid diagnostic tests (RDTs) has improved the diagnosis and treatment of malaria. However, any successful control of malaria will depend on socio-economic factors that influence its management in the community.

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Genetic diversity of Plasmodium falciparum in Bolifamba, on the slopes of Mount Cameroon: influence of MSP1 allelic variants on symptomatic malaria and anaemia

February 26, 2010 - 15:43 -- Ingeborg van Schayk
Author(s): 
Anong, D.N.; Nkuo-Akenji, T.; Fru-Cho, J.; Amambua-Ngwa, A.; Titanji, V.P.K.
Reference: 
Source: Annals of Tropical Medicine and Parasitology, Volume 104, Number 1, January 2010 , pp. 25-33(9)

The influence of the genetic diversity of Plasmodium falciparum infection on the clinical presentation of human malaria was investigated in rural Bolifamba, Cameroon.

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Hematology: Assessing the safety and efficacy of a test-based, targeted donor screening strategy to minimize transfusion transmitted malaria

February 26, 2010 - 12:47 -- Kabogo Ndegwa
Author(s): 
C. R. Seed, G. Kee, T. Wong, M. Law, S. Ismay
Reference: 
Vox Sanguinis, Volume 98, Issue 3, Date: April 2010, Pages: e182-e192

In 2005, the Australian Red Cross Blood Service implemented a malaria antibody testing based strategy for donors with a history of travel/residence in a malaria endemic country or a past history of malaria. This report assesses the safety and efficacy of the strategy since inception.

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Ecology: Genetic association of physically unlinked islands of genomic divergence in incipient species of Anopheles gambiae

February 26, 2010 - 12:45 -- Kabogo Ndegwa
Author(s): 
Bradley J. White, Changde Cheng, Fredric Simard, Carlo Constatini, Nora J. Besansky
Reference: 
Molecular Ecology, Volume 19, Issue 5, Date: March 2010, Pages: 925-939

These results suggest that despite the potential for inter-form gene flow through hybridization, actual (realized) gene flow between M and S may be substantially less than commonly assumed and may not explain most shared variation.

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