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Scientific Articles

Human Plasmodium knowlesi infections in young children in central Vietnam

November 10, 2009 - 10:49 -- Ingeborg van Schayk
Author(s): 
Peter Van den Eede, Hong Nguyen Van, Chantal Van Overmeir, Indra Vythilingam, Thang Ngo Duc, Le Xuan Hung, Hung Nguyen Manh, Jozef Anné, Umberto D'Alessandro, Annette Erhart
Reference: 
Malaria Journal 2009, 8:249 (30 October 2009)

Three of 95 samples from Vietnamese people believed to be infected with P. malariae were also positive for P. knowlesi by PCR. These findings extend the number of countries in Southeast Asia with reports of human P. knowlesi infections.

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Impact of insecticide-treated nets on wild pyrethroid resistant Anopheles epiroticus population from southern Vietnam tested in experimental huts

November 10, 2009 - 10:37 -- Ingeborg van Schayk
Author(s): 
Wim Van Bortel, Vu Duc Chinh, Dirk Berkvens, Niko Speybroeck, Ho Dinh Trung, Marc Coosemans
Reference: 
Malaria Journal 2009, 8:248 (29 October 2009)

This paper describes the results of experimental hut trials to investigate the efficacy of a variety of insecticide-treated nets. The local vector population is partially resistant to multiple pyrethroid insecticides and so the rational behind the study was to determine whether the nets were still effective against resistant mosquitoes.

Antimicrobial Agents: Global resistance surveillance: ensuring antimalarial efficacy in the future

October 31, 2009 - 10:39 -- Ingeborg van Schayk
Author(s): 
Guerin, Philippe J; Bates, Sarah J; Sibley, Carol H
Reference: 
Current Opinion in Infectious Diseases. 22(6):593-600, December 2009

This review summarizes the current status and the challenges to effective surveillance, and suggests approaches for improvement.

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Antimicrobial Agents: Progress in the development of piperaquine combinations for the treatment of malaria

October 31, 2009 - 10:33 -- Ingeborg van Schayk
Tags: 
Author(s): 
D'Alessandro, Umberto
Reference: 
Current Opinion in Infectious Diseases. 22(6):588-592, December 2009

The dosage recommended for children may need to be reviewed and the usefulness of the coadministration with food should be determined. Establishing safety and efficacy of this treatment in pregnancy remains a priority.

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Molecular organization of heterochromatin in malaria mosquitoes of the Anopheles maculipennis subgroup

October 31, 2009 - 10:25 -- Ingeborg van Schayk
Author(s): 
Olga G. Grushko, Maria V. Sharakhova, Vladimir N. Stegnii, Igor V. Sharakhov
Reference: 
Gene, Volume 448, Issue 2, 15 December 2009, Pages 192-197

This study reports an initial survey of the molecular organization of the pericentric heterochromatin in nonmodel species from the A. maculipennis subgroup.

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Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5′-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum

October 31, 2009 - 10:17 -- Ingeborg van Schayk
Author(s): 
Panan Kanchanaphum, Jerapan Krungkrai
Reference: 
Biochemical and Biophysical Research Communications, Volume 390, Issue 2, 11 December 2009, Pages 337-341

The result suggests that the OPRT–OMPDC enzyme complex might have kinetic benefits and thermal stability significantly different from the monofunctional enzyme.

Short Communication: Species B of Anopheles culicifacies (Diptera: Culicidae) is reproductively less fit than species A and C of the complex

October 31, 2009 - 10:00 -- Ingeborg van Schayk
Author(s): 
Anil Sharma, Hardev Parasher, O.P. Singh, Tridibes Adak
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 316-319

The present attempt is made to study and compare the fecundity of the differentially susceptible members of the An. culicifacies complex.

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Mechanisms of malarial anaemia: Potential involvement of the Plasmodium falciparum low molecular weight rhoptry-associated proteins

October 31, 2009 - 09:51 -- Ingeborg van Schayk
Author(s): 
Nancy W. Awah, Marita Troye-Blomberg, Klavs Berzins, Jürg Gysin
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 295-302

In this study we further investigated the mechanisms mediating the destruction of nEs in the development of severe malarial anaemia and the possible involvement of RAP-2/RSP-2 and other members of the low molecular weight rhoptry complex (RAP-1: rhoptry-associated protein-1 and RAP-3: rhoptry-associated protein-3).

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Bioassay-guided fractionation and in vivo antiplasmodial effect of fractions of chloroform extract of Artemisia maciverae Linn

October 31, 2009 - 09:43 -- Ingeborg van Schayk
Author(s): 
A.C. Ene, S.E. Atawodi, D.A. Ameh, G.I. Ndukwe, H.O. Kwanashie
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 288-294,doi:10.1016/j.actatropica.2009.08.016

In the search for new plant-derived anti-malarial compounds, chromatographic fractions of chloroform extract of whole plants of Artemisia maciverae were tested in vivo using chloroquine resistant and chloroquine sensitive Plasmodium berghei NK 65 infected Swiss albino mice.

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Public and private sector treatment of malaria in Lao PDR

October 31, 2009 - 09:35 -- Ingeborg van Schayk
Author(s): 
Daisuke Nonaka, Kongshin Vongseththa, Jun Kobayashi, Somboun Bounyadeth, Shigeyuki Kano, Samlane Phompida, Masamine Jimba
Reference: 
Acta Tropica, Volume 112, Issue 3, December 2009, Pages 283-287

This study aimed to examine the care-seeking choices for treatment of a febrile illness compatible with malaria in the public and private sectors in Lao PDR.

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