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Scientific Articles

Retrospective Evaluation of 31 Malaria Cases Hospitalized in Our Clinic Between 2012-2018

January 15, 2020 - 09:13 -- Open Access
Sarı ND, Yörük G
Turkiye Parazitol Derg 2019;43(4):170-4

Malaria is an infection disease caused by plamodium parasite. Sporadic cases have not been observed since 2011, but imported  cases  still  present  owing  to  travel.  In  this  study,  we  aimed  to  evaluate  labotauary  and  clinical  findings  patients  with  malaria who were hospitalized and treated in our hospital.

NOT Open Access | Mannosylated liposomes formulated with whole parasite P. falciparum blood-stage antigens are highly immunogenic in mice

January 15, 2020 - 09:12 -- NOT Open Access
Ssemaganda A, Giddam AK, Low LM, Liu XQ, Ho MF, Zaman M, Hussein WM, Skwarczynski M, Toth I, Stanisic DI, Good MF
Vaccine, 2019 Dec 19. pii: S0264-410X(19)31617-2

The development of a blood-stage malaria vaccine has largely focused on the subunit approach. However, the limited success of this strategy, mainly due to antigenic polymorphism and the failure to maintain potent parasite-specific immune responses, indicates that other approaches must be considered. Whole parasite (WP) vaccines offer many advantages over sub-units; they represent every antigen on the organism, thus limiting the effects of antigenic polymorphism, and similarly they compensate for individual Immune-Response (Ir) gene-regulated non-responsiveness to any particular antigen. From a development perspective, they negate the need to identify and compare the relative efficacies of individual candidate antigens. WP vaccines induce protective immunity that is largely cell-mediated.

Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island

January 15, 2020 - 09:10 -- Open Access
Liang XY, Chen JT, Ma YB, Huang HY, Xie DD, Monte-Nguba SM, Ehapo CS, Eyi UM, Zheng YZ, Liu XZ, Zha GC, Lin LY, Chen WZ, Zhou X, Lin M
Mol Genet Genomic Med. 2019 Dec 24:e1061

Glucose‐6‐phosphate dehydrogenase (G6PD) is an essential enzyme that protects red blood cells from oxidative damage. Although G6PD‐deficient alleles appear to confer a protective effect of malaria, the link with clinical protection against Plasmodium infection is conflicting.

NOT Open Access | Oligomers of carrageenan regulate functional activities and artemisinin production in Artemisia annua L. exposed to arsenic stress

January 15, 2020 - 09:09 -- NOT Open Access
Naeem M, Nabi A, Aftab T, Khan MMA
Protoplasma, 2019 Dec 24

Recently, a promising technique has come forward in field of radiation-agriculture in which the natural polysaccharides are modified into useful oligomers after depolymerization. Ionizing radiation technology is a simple, pioneering, eco-friendly, and single step degradation process which is used in exploiting the efficiency of the natural polysaccharides as plant growth promoters. Arsenic (As) is a noxious and toxic to growth and development of medicinal plants. Artemisinin is obtained from the leaves of Artemisia annua L., which is effective in the treatment of malaria.

Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites

January 15, 2020 - 09:07 -- Open Access
Siden-Kiamos I, Goosmann C, Buscaglia CA, Brinkmann V, Matuschewski K, Montagna GN
Molecular and Biochemical Parasitology, Volume 235, January 2020, 111247

Gliding motility and cell invasion are essential for the successful transmission of Plasmodium parasites. These processes rely on an acto-myosin motor located underneath the parasite plasma membrane. The Myosin A-tail interacting protein (MTIP) connects the class XIV myosin A (MyoA) to the gliding-associated proteins and is essential for assembly of the motor at the inner membrane complex.

The resistome and genomic reconnaissance in the age of malaria elimination

January 15, 2020 - 09:06 -- Open Access
Kümpornsin K, Kochakarn T, Chookajorn T
Disease Models & Mechanisms, vol. 12 no. 12, dmm040717

Malaria is an infectious disease caused by parasitic protozoa in the Plasmodium genus. A complete understanding of the biology of these parasites is challenging in view of their need to switch between the vertebrate and insect hosts. The parasites are also capable of becoming highly motile and of remaining dormant for decades, depending on the stage of their life cycle.

NOT Open Access | A sensory appendage protein protects malaria vectors from pyrethroids

January 15, 2020 - 09:05 -- NOT Open Access
Ingham VA, Anthousi A, Douris V, Harding NJ, Lycett G, Morris M, Vontas J, Ranson H
Nature volume 577, pages376–380(2020)

Pyrethroid-impregnated bed nets have driven considerable reductions in malaria-associated morbidity and mortality in Africa since the beginning of the century1. The intense selection pressure exerted by bed nets has precipitated widespread and escalating resistance to pyrethroids in African Anopheles populations, threatening to reverse the gains that been made by malaria control2. Here we show that expression of a sensory appendage protein (SAP2), which is enriched in the legs, confers pyrethroid resistance to Anopheles gambiae.

P. falciparum gametocyte density and infectivity in peripheral blood and skin tissue of naturally infected parasite carriers in Burkina Faso

January 15, 2020 - 09:03 -- Open Access
Meibalan E, Barry A, Gibbins MP, Awandu S, Meerstein-Kessel L, Achcar F, Bopp S, Moxon C, Diarra A, Debe S, Ouédraogo N, Barry-Some I, Badoum E, Fagnima T, Lanke K, Gonçalves BP, Bradley J, Wirth D, Drakeley C, Guelbeogo WM, Tiono AB, Marti M, Bousema T
The Journal of Infectious Diseases, jiz680

Plasmodium falciparum transmission depends on mature gametocytes that can be ingested by mosquitoes taking a bloodmeal on human skin. Although gametocyte skin sequestration has long been hypothesized as important contributor to efficient malaria transmission, this has never been formally tested.

Multigenic architecture of piperaquine resistance trait in Plasmodium falciparum

January 15, 2020 - 08:59 -- Open Access
Silva M, Calçada C, Teixeira M, Veiga MI, Ferreira PE
Lancet Infect Dis. 2020 Jan; 20(1):26-27

William L Hamilton and colleagues1 and Rob W van der Pluijm and colleagues2 described the genomic evolution of Plasmodium falciparum malaria and the spread of resistance in this species to dihydroartemisinin–piperaquine in Southeast Asia. Resistance in the region has been associated with crt polymorphisms, 1, 2, 3 copy number variations in plasmepsins, 1, 2, 3, 4, 5 and mdr1 genes.4, 5

A novel model for malaria prediction based on ensemble algorithms

January 15, 2020 - 08:56 -- Open Access
Wang M, Wang H, Wang J, Liu H, Lu R, Duan T, Gong X, Feng S, Liu Y, Cui Z, Li C, Ma J
PLoS ONE 14(12): e0226910

Most previous studies adopted single traditional time series models to predict incidences of malaria. A single model cannot effectively capture all the properties of the data structure. However, a stacking architecture can solve this problem by combining distinct algorithms and models. This study compares the performance of traditional time series models and deep learning algorithms in malaria case prediction and explores the application value of stacking methods in the field of infectious disease prediction.


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