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Scientific Articles

Methodology: A simple cost-effective high performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies

October 29, 2009 - 12:22 -- Ingeborg van Schayk
Author(s): 
Grace O Gbotosho, Christian T Happi, Abayomi O Sijuade, Akin Sowunmi, Ayoade MJ Oduola
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Malaria Journal 2009, 8:238 (24 October 2009)

Efforts in this study were thus devoted to development and evaluation of a simple, cost-effective and sensitive method for quantification of sulphadoxine in small capillary samples of whole blood dried on filter paper.

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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial

October 29, 2009 - 12:18 -- Ingeborg van Schayk
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Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
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Malaria Journal 2009, 8:237 (24 October 2009)

Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants.

Presumptive treatment with SP was more efficacious than weekly chloroquine in reducing prevalence of malaria in children with sickle cell anaemia. Continued use of chloroquine for malaria chemoprophylaxis in children with sickle cell anaemia in Uganda does not seem to be justified. ClinicalTrials.gov Identifier: NCTOO124267

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Use of short message service (SMS) to improve malaria chemoprophylaxis compliance after returning from a malaria endemic area

October 29, 2009 - 12:15 -- Ingeborg van Schayk
Author(s): 
Lenaick Ollivier, Olivier Romand, Catherine Marimoutou, Remy Michel, Corinne Pognant, Alain Todesco, Rene Migliani, Dominique Baudon, Jean-Paul Boutin
Reference: 
Malaria Journal 2009, 8:236 (23 October 2009)

Malaria chemoprophylaxis compliance is suboptimal among French soldiers despite the availability of free malaria chemoprophylaxis and repeated health education before, during and after deployments to malaria endemic areas.

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Characterization of immunoglobulin G antibodies to Plasmodium falciparum sporozoite surface antigen MB2 in malaria exposed individuals

October 29, 2009 - 12:12 -- Ingeborg van Schayk
Author(s): 
Thanh V Nguyen, John B Sacci Jr, Patricia de la Vega, Chandy C John, Anthony A James, Angray S Kang
Reference: 
Malaria Journal 2009, 8:235 (23 October 2009)

MB2 protein is a sporozoite surface antigen on the human malaria parasite Plasmodium falciparum. A preliminary analysis of the human humoral response against MB2 indicates that it may be an additional highly conserved target for immune intervention at the pre-erythrocytic stage of P. falciparum life cycle.

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Habitat stability and occurrences of malaria vector larvae in western Kenya highlands

October 29, 2009 - 12:07 -- Ingeborg van Schayk
Author(s): 
Yousif E Himeidan, Guofa Zhou, Laith Yakob, Yaw Afrane, Stephen Munga, Harrysonne Atieli, El-Amin El-Rayah, Andrew K Githeko, Guiyun Yan
Reference: 
Malaria Journal 2009, 8:234 (21 October 2009)

Although the occurrence of malaria vector larvae in the valleys of western Kenya highlands is well documented, knowledge of larval habitats in the uphill sites is lacking. Given that most inhabitants of the highlands actually dwell in the uphill regions, it is important to develop understanding of mosquito breeding habitat stability in these sites in order to determine their potential for larval control.

The occurrence of malaria vector larvae in the hilltop area was uncommon as a result of the low availability and high instability of habitats. To optimize the cost-effectiveness of malaria interventions in the western Kenya highlands, larval control should be focused primarily along the streams, as these are likely the only productive habitats at high altitude.

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Managing insecticide resistance in malaria vectors by combining carbamate-treated plastic wall sheeting and pyrethroid-treated bed nets

October 29, 2009 - 12:00 -- Ingeborg van Schayk
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Author(s): 
Armel Djenontin, Joseph Chabi, Thierry Baldet, Seth Irish, Cedric Pennetier, Jean-Marc Hougard, Vincent Corbel, Martin Akogbeto, Fabrice Chandre
Reference: 
Malaria Journal 2009, 8:233 (20 October 2009)

Pyrethroid resistance is now widespread in Anopheles gambiae, the major vector for malaria in sub-Saharan Africa. This resistance may compromise malaria vector control strategies that are currently in use in endemic areas. In this context, a new tool for management of resistant mosquitoes based on the combination of a pyrethroid-treated bed net and carbamate-treated plastic sheeting was developed.

Mosquito abundance and behavior in the influence area of the hydroelectric complex on the Madeira River, Western Amazon, Brazil

October 25, 2009 - 17:51 -- Bart G.J. Knols
Author(s): 
Rafael Mesquita Bastos Cruz, Luiz Herman Soares Gil, Alexandre de Almeida e Silva, Maisa da Silva Araújo, Tony Hiroshi Katsuragawa
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1174-1176, doi:10.1016/j.trstmh.2008.09.007

Malaria is currently highly prevalent and restricted to the north of Brazil, and its dynamics are severely affected by human environmental changes, such as the large dam construction recently approved by the Brazilian Government in Rondônia. We studied the mosquito fauna and behavior before hydroelectric construction. Mosquitoes were captured by human landing catches on the riversides of the Madeira River in Porto Velho, Rondônia. 

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The development and evaluation of a single step multiplex PCR for simultaneous detection of Anopheles annularis group mosquitoes, human host preference and Plasmodium falciparum sporozoite presence

October 25, 2009 - 17:45 -- Bart G.J. Knols
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Author(s): 
Sunita Swain, Amitav Mohanty, Namita Mahapatra, S.K. Parida, N.S. Marai, H.K. Tripathy, Santanu K. Kar, Rupenangshu K. Hazra
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Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1146-1152, doi:10.1016/j.trstmh.2009.03.022

The Anopheles annularis group mosquitoes, subgenus Cellia Theobald (Diptera: Culicidae), includes five recognized species: An. annularis Van der Wulp, An. nivipes Theobald, An. pallidus Theobald, An. philippinensis Ludlow and An. schueffneri Stanton. From these five, the three most common species found in Orissa were considered for this study because of their remarkable vectorial and behavioral variation and the important role they play in malaria transmission. To identify and understand their role in malaria transmission we developed a single multiplex PCR-based assay.  This one-step PCR-based method constitutes a very powerful tool in large surveys of anopheline populations.

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Evidence of multiple pyrethroid resistance mechanisms in the malaria vector Anopheles gambiae sensu stricto from Nigeria

October 25, 2009 - 17:39 -- Bart G.J. Knols
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Author(s): 
T.S. Awolola, O.A. Oduola, C. Strode, L.L. Koekemoer, B. Brooke, H. Ranson
Reference: 
Transactions of the Royal Society of Tropical Medicine and Hygiene, Volume 103, Issue 11, November 2009, Pages 1139-1145, doi:10.1016/j.trstmh.2008.08.021

 Pyrethroid insecticide resistance in Anopheles gambiae sensu stricto is a major concern to malaria vector control programmes. Resistance is mainly due to target-site insensitivity arising from a single point mutation, often referred to as knockdown resistance (kdr). Metabolic-based resistance mechanisms have also been implicated in pyrethroid resistance in East Africa and are currently being investigated in West Africa. Here we report the co-occurrence of both resistance mechanisms in a population of An. gambiae s.s. from Nigeria.

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