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Scientific Articles

Open Access : Clinical Microbiology : Evaluation of the pyrrole insecticide chlorfenapyr against pyrethroid resistant and susceptible Anopheles funestus (Diptera: Culicidae)

December 17, 2009 - 13:21 -- Kabogo Ndegwa
Author(s): 
S. V. Oliver, M. L. Kaiser, O. R. Wood, M. Coetzee, M. Rowland, B. D. Brooke
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 127-131

Objective : To evaluate the pyrrole insecticide chlorfenapyr, which has a novel non-neurotoxic mode of action and is a promising alternative to conventional adulticides, against Anopheles funestus. Method : The toxicity of a range of concentrations of chlorfenapyr against pyrethroid resistant and susceptible laboratory reared southern African An. funestus was assessed using standard WHO protocols and analysed using probit analysis.

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Open Access | Clinical Microbiloby:Low-high season variation in Plasmodium falciparum erythrocyte binding antigen 175 (eba-175) allelic forms in malaria endemic area of Burkina Faso

December 17, 2009 - 13:19 -- Kabogo Ndegwa
Author(s): 
Issiaka Soulama, Edith C. Bougouma, Amidou Diarra, Issa Nebie, Sodiomon B. Sirima
Reference: 
Tropical Medicine & International Healt,Volume 15, Issue 1, Date: January 2010, Pages: 51-59

To assess the impact of seasonal variation on the distribution of the eba-175 allelic forms in the area where malaria transmission is markedly seasonal.

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Open Access | Clinical Microbiology : Therapeutic efficacy of chloroquine and sequence variation in pfcrt gene among patients with falciparum malaria in central India

December 17, 2009 - 13:17 -- Kabogo Ndegwa
Author(s): 
Praveen Kumar Bharti, Mohammad Tauqeer Alam, Robert Boxer, Man Mohan Shukla, Sant P. Gautam, Yagya D. Sharma, Neeru Singh
Reference: 
Tropical Medicine & International Health,Volume 15, Issue 1, Date: January 2010, Pages: 33-40

To assess the therapeutic efficacy of chloroquine (CQ) treatment against uncomplicated Plasmodium falciparum infections in a tribal population of central India (Madhya Pradesh) and to investigate the prevalence of mutant P. falciparum chloroquine-resistant transporter (pfcrt) gene in the parasite population.

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Open Access | Viewpoint: Health systems strengthening through insurance subsidies: the GFATM experience in Rwanda

December 17, 2009 - 13:10 -- Kabogo Ndegwa
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Author(s): 
Andreas Kalk , Natalie Groos , Jean-Claude Karasi and Elisabeth Girrbach
Reference: 
Tropical Medicine & International Health Volume 15 Issue 1, Pages 94 – 97

This project intends to enhance financial access to health care by subsidising health insurance for the poor in order to combat the three diseases successfully.

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Open Access | Cell and Molecular Biology: Shape- and Chemical Feature-Based 3D-Pharmacophore Model Generation and Virtual Screening: Identification of Potential Leads for P. falciparum DHFR Enzyme Inhibition

December 17, 2009 - 13:08 -- Patrick Sampao
Author(s): 
Legesse Adane, Dhilon. S. Patel and Prasad V. Bharatam
Reference: 
Chemical Biology & Drug Design, Volume 75 Issue 1, Pages 115 - 126

The hits reported in this article showed good potential to be inhibitors of the above Pf DHFRs based on their (i) best-fit values (ii) binding scores (iii) binding modes and (iv) interactions with the key amino acid residues (Asp54, Ileu/Leu164, Asn/Ser108 and Ile14).

Open Access | Clinical Microbiology: Are malaria treatment expenditures catastrophic to different socio-economic and geographic groups and how do they cope with payment? A study in southeast Nigeria

December 17, 2009 - 13:05 -- Kabogo Ndegwa
Author(s): 
Obinna Onwujekwe , Kara Hanson, Benjamin Uzochukwu , Hyacinth Ichoku , Edith Ike and Benjamin Onwughalu
Reference: 
Tropical Medicine & International Health, Volume 15 Issue 1, Pages 18 – 25

To determine the inequities in the household income depletion resulting from malaria treatment expenditures, the sacrifice of basic household needs (catastrophe) and the differences in payment strategies among different socio-economic and geographic groups in southeast Nigeria.

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Short communication: Investigation of memory responses following Plasmodium chabaudi AS infection in mice distinct in susceptibility to clinical malaria

December 16, 2009 - 10:44 -- Ingeborg van Schayk
Author(s): 
Jiraprapa Wipasa, Panida Hemsokana, Tunlaya Ruankham & Surat Hongsibsong
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 283-287

This study aimed to investigate the development of memory responses in susceptible A/J and resistant C57BL/6 mice which differ in the degree of susceptibility to clinical malaria following P. chabaudi AS infection.

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Amaranthus oleracea and Euphorbia hirta: natural potential larvicidal agents against the urban Indian malaria vector, Anopheles stephensi Liston (Diptera: Culicidae)

December 16, 2009 - 10:34 -- Ingeborg van Schayk
Author(s): 
Preeti Sharma, Lalit Mohan & C. N. Srivastava
Reference: 
Parasitology Research, Volume 106, Number 1 / December, 2009 : 171-176

The present work highlights the larvicidal property of extracts of Amaranthus oleracea and Euphorbia hirta against the third instar larvae of Anopheles stephensi, the urban malaria vector.

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Plasmodium falciparum culture: The benefits of shaking

December 16, 2009 - 08:03 -- Kabogo Ndegwa
Author(s): 
Richard J.W. Allen, Kiaran Kirk
Reference: 
Molecular and Biochemical Parasitology, Volume 169, Issue 1, January 2010, Pages 63-65, doi:10.1016/j.molbiopara.2009.09.005

Here, extending previous work, we have quantified the favourable effects of continuous agitation on three indices of culture growth

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Open Access | Plasmodium falciparum Infection Significantly Impairs Placental Cytokine Profile in HIV Infected Cameroonian Women

December 15, 2009 - 21:00 -- Ingeborg van Schayk
Author(s): 
Kfutwah A, Mary JY, Lemen B, Leke R, Rousset D, et al.
Reference: 
PLoS ONE 4(12): e8114

These results show that P. falciparum infection profoundly modifies the placenta cytokine environment and acts as a confounding factor, masking the impact of HIV-1 in co-infected women.

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