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Scientific Articles

Design of a fixed-dose paediatric combination of artesunate and amodiaquine hydrochloride

March 5, 2010 - 11:14 -- Kabogo Ndegwa
Author(s): 
C. Okwelogu, B. Clark, M. de Matas, D. Ifudu, C. Igwilo, B. Silva, P. York
Reference: 
International Journal of Pharmaceutics, Volume 387, Issues 1-2, 15 March 2010, Pages 19-25

It was therefore concluded that a stable, versatile paediatric preparation of the two drugs could be prepared by blending pre-formulated granules containing the individual constituents rather than producing a combined granule comprising intimate mixtures of the two agents.

Short Communication: Near-fixation of a Pfmsp1 block 2 allelic variant in genetically diverse Plasmodium falciparum populations across Western Colombia

March 5, 2010 - 11:07 -- Kabogo Ndegwa
Author(s): 
Judy Natalia Jiménez, Georges Snounou, Frank Letourneur, Laurent Rénia, Iván D. Vélez, Carlos E. Muskus
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 67-70

Assessment of the genetic diversity of Plasmodium falciparum in 110 Colombian isolates revealed that nearly all the parasites in the 97 isolates collected in endemic regions west of the Andes shared the same Pfmsp1 block 2 MAD20-type allelic variant, despite showing high diversity for other genetical markers.

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Short communication: Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

March 5, 2010 - 11:00 -- Kabogo Ndegwa
Author(s): 
Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 63-66

The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area.

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Spatial distribution and r-DNA second internal transcribed spacer characterization of Anopheles dirus (Diptera: Culicidae) complex species in north-east India

March 5, 2010 - 10:08 -- Kabogo Ndegwa
Author(s): 
Anil Prakash, D.K. Sarma, D.R. Bhattacharyya, P.K. Mohapatra, K. Bhattacharjee, K. Das, J. Mahanta
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 49-54

The identity and distribution of the prevalent member species of the Anopheles dirus complex mosquitoes in the north-eastern region of India was investigated in a cross-sectional study.

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Relation between vitamin B12 and folate status, and hemoglobin concentration and parasitemia during acute malaria infections in Colombia

March 5, 2010 - 09:30 -- Kabogo Ndegwa
Author(s): 
Olga Caicedo, Eduardo Villamor, Yibby Forero, José Ziade, Pilar Pérez, Francisco Quiñones, Myriam Arévalo-Herrera, Sócrates Herrera
Reference: 
Acta Tropica, Volume 114, Issue 1, April 2010, Pages 17-21

Since micronutrient deficiencies are highly prevalent in malaria-endemic areas and appear to contribute to anemia etiology, we conducted a cross-sectional study in Tumaco, Colombia, to examine the associations between plasma vitamin B12 or erythrocyte folate concentrations and hemoglobin (Hb) among 96 adults with predominantly Plasmodium falciparum malaria. 

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Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

March 5, 2010 - 09:10 -- Kabogo Ndegwa
Author(s): 
Lin Zhou, André Alker, Jonathan L. Vennerstrom et al.
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1555-1558

The antimalarial synthetic ozonide OZ277 (RBx11160) was hydroxylated by human liver microsomes at the distal bridgehead carbon atoms of the spiroadamantane substructure to form two carbinol metabolites devoid of antimalarial activity.

An efficient route into synthetically challenging bridged achiral 1,2,4,5-tetraoxanes with antimalarial activity

March 5, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Gemma L. Ellis, Richard Amewu, Charlotte Hall, Karen Rimmer, Steven A. Ward, Paul M. O’Neill
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 18, Issue 5, 1 March 2008, Pages 1720-1724

Using this methodology a range of bridged tetraoxanes which display good in vitro antimalarial activity were synthesized.

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The South American Plasmodium falciparum var gene repertoire is limited, highly shared and possibly lacks several antigenic types

March 5, 2010 - 08:59 -- Kabogo Ndegwa
Author(s): 
Letusa Albrecht, Catarina Castiñeiras, Bruna O. Carvalho, Simone Ladeia-Andrade, Natal Santos da Silva, Erika H.E. Hoffmann, Rosimeire C. dalla Martha, Fabio T.M. Costa, Gerhard Wunderlich
Reference: 
Gene, Volume 453, Issues 1-2, 15 March 2010, Pages 37-44

The frequently observed mild outcomes of falciparum malaria in many places of the Amazon area prompted us to ask whether a globally restricted variant (var) gene repertoire is present in currently circulating and older isolates of this area.

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Open Access | A Major Role for the Plasmodium falciparum ApiAP2 Protein PfSIP2 in Chromosome End Biology

March 3, 2010 - 13:51 -- Ingeborg van Schayk
Author(s): 
Christian Flueck, Richard Bartfai, Igor Niederwieser, Kathrin Witmer, Blaise T. F. Alako, Suzette Moes, Zbynek Bozdech, Paul Jenoe, Hendrik G. Stunnenberg, Till S. Voss
Reference: 
PLoS Pathog 6(2): e1000784

These findings are highly relevant for our understanding of chromosome end biology and variegated expression in P. falciparum and other eukaryotes, and for the future analysis of the role of ApiAP2-DNA interactions in parasite biology.

Open Access | Defining species specific genome differences in malaria parasites

March 3, 2010 - 12:35 -- Ingeborg van Schayk
Author(s): 
Liew KJ, Hu G, Bozdech Z, Preiser PR
Reference: 
BMC Genomics 2010, 11:128 (23 February 2010)

To improve the current annotation and gene identification status of the draft genomes of P. berghei, P. chabaudi and P. yoelii, we performed genome-wide comparisons between these three species.

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