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Scientific Articles

In-vitro safety and off-target profile of the anti-parasitic arylmethylaminosteroid 1o

May 7, 2020 - 11:33 -- Open Access
Blum L, Gul S, chiffmann S, et al.
Sci Rep. 2020 May 5;10(1):7534

Parasite-mediated diseases like malaria and schistosomiasis are growing health problems worldwide and novel drug candidates are urgently needed. In this study, the in-vitro safety profile of steroid compound 1o (sc1o), effective against the parasites Plasmodium falciparum and Schistosoma mansoni with an IC50 value of 5 nM, was characterized. We assessed viability/proliferation, apoptosis and cell cycle tests to determine the cytotoxic profile of sc1o in cancer cells.

Epidemiological characteristics of imported malaria in Shandong Province, China, from 2012 to 2017

May 7, 2020 - 11:32 -- Open Access
Yu T, Fu Y, Kong X, Liu X, Yan G, Wang Y
Sci Rep. 2020 May 5;10(1):7568

Shandong Province, China, has been implementing a malaria elimination program. In this study, we analyzed the epidemiological characteristics of malaria imported into Shandong Province between 2012 and 2017 to provide scientific data for the elimination of malaria. In this epidemiological study, we examined the status of malaria in 2012–2017 in Shandong Province, China.

Demographic and health community-based surveys to inform a malaria elimination project in Magude district, southern Mozambique

May 7, 2020 - 11:30 -- Open Access
Galatas B, Nhacolo A, Sacoor C, et al.
BMJ Open. 2020 May 5;10(5):e033985

A Demographic and Health Platform was established in Magude in 2015, prior to the deployment of a project aiming to evaluate the feasibility of malaria elimination in southern Mozambique, named the Magude project. This platform aimed to inform the design, implementation and evaluation of the Magude project, through the identification of households and population; and the collection of demographic, health and malaria information.

Reactions of Plasmodium falciparum Ferredoxin:NADP+ Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study

May 7, 2020 - 11:26 -- Open Access
Lesanavičius M, Aliverti A, Šarlauskas J, Čėnas N
Int J Mol Sci. 2020 May 2;21(9). pii: E3234

Ferredoxin:NADP+ oxidoreductase from Plasmodium falciparum (PfFNR) catalyzes the NADPH-dependent reduction of ferredoxin (PfFd), which provides redox equivalents for the biosynthesis of isoprenoids and fatty acids in the apicoplast. Like other flavin-dependent electrontransferases, PfFNR is a potential source of free radicals of quinones and other redox cycling compounds.

Comparison of swarming, mating performance and longevity of males Anopheles coluzzii between individuals fed with different natural fruit juices in laboratory and semi-field conditions

May 6, 2020 - 16:11 -- Open Access
Charles Nignan, Abdoulaye Niang, Abdoulaye Diabaté, et al.
Malaria Journal 2020 19:173, 6 May 2020

It is assumed that malaria vectors feed on locally available nectar sources to obtain energy. Sugar feeding is energetically critical for the Anopheles male swarming and mating activities. However, little is known about the impact of local nectar feeding on male physiological development and its consequences on male mosquito life traits in the malaria control context. This study aimed to evaluate the influence of local fruit juices on the life traits of males Anopheles coluzzii.

The malaria burden: A look at 3 years outpatient malaria clinic visits in a university community town in Southeast of Nigeria

May 6, 2020 - 16:08 -- Open Access
Badger-Emeka LI
Niger J Clin Pract. 2020 May;23(5):711-719

One of the Nigerian vision 2020 National Malaria strategic plans is control and subsequent eradication of malaria. The present report looks at outpatient malaria clinic visits for a 3-year period with a view of ascertaining whether control measures put in place over decades are being reflected in the decline of the disease.

NOT Open Access | Inhibition of EIF-5A prevents apoptosis in human cardiomyocytes after malaria infection

May 6, 2020 - 16:06 -- NOT Open Access
Kaiser A, Heiss K, Mueller AK, Fimmers R, Matthes J, Njuguna JT
Amino Acids. 2020 May 4.

In this study, a determination of Troponin I and creatine kinase activity in whole-blood samples in a cohort of 100 small infants in the age of 2–5 years from Uganda with complicated Plasmodium falciparum malaria suggests the prevalence of cardiac symptoms in comparison to non-infected, healthy patients. Troponin I and creatine kinase activity increased during infection. Different reports showed that complicated malaria coincides with hypoxia in children.

NOT Open Access | The influence of feeding behaviour and temperature on the capacity of mosquitoes to transmit malaria

May 6, 2020 - 16:04 -- NOT Open Access
Suh E, Grossman MK, Waite JL, Dennington NL, Sherrard-Smith E, Churcher TS, Thomas MB
Nat Ecol Evol. 2020 May 4.

Insecticide-treated bed nets reduce malaria transmission by limiting contact between mosquito vectors and human hosts when mosquitoes feed during the night. However, malaria vectors can also feed in the early evening and in the morning when people are not protected. Here, we explored how the timing of blood feeding interacts with environmental temperature to influence the capacity of Anopheles mosquitoes to transmit the human malaria parasite Plasmodium falciparum.

A microsporidian impairs Plasmodium falciparum transmission in Anopheles arabiensis mosquitoes

May 6, 2020 - 16:03 -- Open Access
Herren JK, Mbaisi L, Sinkins SP, et al.
Nat Commun. 2020 May 4;11(1):2187

A possible malaria control approach involves the dissemination in mosquitoes of inherited symbiotic microbes to block Plasmodium transmission. However, in the Anopheles gambiae complex, the primary African vectors of malaria, there are limited reports of inherited symbionts that impair transmission. We show that a vertically transmitted microsporidian symbiont (Microsporidia MB) in the An. gambiae complex can impair Plasmodium transmission.

Not Open Access | Activity of epigenetic inhibitors against Plasmodium falciparum asexual and sexual blood stages

May 6, 2020 - 16:02 -- NOT Open Access
Vanheer LN, Zhang H, Lin G, Kafsack BFC
Antimicrob Agents Chemother. 2020 May 4. pii: AAC.02523-19

Earlier genetic and inhibitor studies have shown that epigenetic regulation of gene expression is critical for malaria parasite survival in multiple life stages and a promising target for new anti-malarials.


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