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Scientific Articles

Dimeric cyclohexane-1,3-dione oximes inhibit wheat acetyl-CoA carboxylase and show anti-malarial activity

July 16, 2010 - 08:20 -- Kabogo Ndegwa
Author(s): 
Theola Louie, C. Dean Goodman, Georgina A. Holloway, Geoffrey I. McFadden, Vanessa Mollard, Keith G. Watson
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 15, 1 August 2010, Pages 4611-4613

A series of dimeric 1,3-cyclohexanedione oxime ethers were synthesized and found to have significant antiplasmodial activity with IC50’s in the range 3–12 μM.

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Synthesis of novel α-pyranochalcones and pyrazoline derivatives as Plasmodium falciparum growth inhibitors

July 16, 2010 - 08:17 -- Kabogo Ndegwa
Author(s): 
Gajanan Wanare, Rahul Aher, Neha Kawathekar, Ravi Ranjan, Naveen Kumar Kaushik, Dinkar Sahal
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 15, 1 August 2010, Pages 4675-4678

Both the lack of a credible malaria vaccine and the emergence and spread of parasites resistant to most of the clinically used antimalarial drugs and drug combination have aroused an imperative need to develop new drugs against malaria.

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

July 16, 2010 - 08:00 -- Kabogo Ndegwa
Author(s): 
Duong Nhu, Sandra Duffy, Vicky M. Avery, Andrew Hughes, Jonathan B. Baell
Reference: 
Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 15, 1 August 2010, Pages 4496-4498

We report on novel 3-arylamino-6-benzylamino-1,2,4,5-tetrazines with potent activity against Plasmodium falciparum.

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Open Access | Community perceptions of malaria and malaria treatment behaviour in a rural district of Ghana: implications for artemisinin combination therapy

July 15, 2010 - 10:04 -- Patrick Sampao
Author(s): 
Kwaku P., Livesy A., et al.
Reference: 
BMC Public Health 2010, 10:409

We report the perceptions of malaria and malaria treatment behaviour, the community awareness of and perceptions about AS-AQ two years after the introduction of this ACT treatment for malaria.

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6-(4′-Aryloxy-phenyl)vinyl-1,2,4-trioxanes: A new series of orally active peroxides effective against multidrug-resistant Plasmodium yoelii in Swiss mice

July 15, 2010 - 09:52 -- Kabogo Ndegwa
Author(s): 
Chandan Singh, Ved Prakash Verma, Niraj Krishna Naikade, Ajit Shankar Singh, Mohammad Hassam, Sunil. K. Puri
Reference: 
Bioorganic & Medicinal Chemistry Letters Volume 20, Issue 15, 1 August 2010, Pages 4459-4463

A new series of 6-(4′-aryloxy-phenyl)vinyl-1,2,4-trioxanes 10a–d, 11a–d, and 12a–d have been synthesized and evaluated for their antimalarial activity against multidrug-resistant Plasmodium yoelii in Swiss mice by oral route.

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Open Access | Commentary: Genome-wide association studies in Plasmodium species

July 15, 2010 - 09:43 -- Patrick Sampao
Author(s): 
Bridget Penman, Caroline Buckee, Sunetra Gupta and Sean Nee
Reference: 
BMC Biology 2010, 8:90

A recent study in BMC Genetics has found that populations of the malaria parasite Plasmodium vivax should be amenable to GWAS searching for a genetic basis of parasite pathogenicity.

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Open Access | CRIMALDDI: a co-ordinated, rational, and integrated effort to set logical priorities in anti-malarial drug discovery initiatives

July 15, 2010 - 09:01 -- Kabogo Ndegwa
Author(s): 
Boulton IC, Nwaka S, Bathurst I, Lanzer M, Taramelli D, Vial H, Doerig C, Chibale K, Ward SA
Reference: 
Malaria Journal 2010, 9:202 (13 July 2010)

Despite increasing efforts and support for anti-malarial drug R&D, globally anti-malarial drug discovery and development remains largely uncoordinated and fragmented.

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Open Access | Community acceptability of use of rapid diagnostic tests for malaria by community health workers in Uganda

July 14, 2010 - 12:54 -- Kabogo Ndegwa
Author(s): 
Mukanga D, Tibenderana JK, Kiguli J, Pariyo GW, Waiswa P, Bajunirwe F, Mutamba B, Counihan H, Ojiambo G, Kallander K
Reference: 
Malaria Journal 2010, 9:203 (13 July 2010)

Use of RDTs by CMDs is likely to be acceptable by community members given that CMDs are properly trained, and receive regular technical supervision and logistical support. A well-designed behaviour change communication strategy is needed to address the anticipated programmatic challenges as well as community fears and stigma about drawing blood.

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Open Access | Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana

July 14, 2010 - 08:06 -- Kabogo Ndegwa
Author(s): 
Krefis A, Schwarz N, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J
Reference: 
Malaria Journal 2010, 9:201 (13 July 2010)

The socioeconomic situation is significantly associated with malaria even in holoendemic rural areas where economic differences are not much pronounced. Valid classification of the socioeconomic level is crucial to be considered as confounder in intervention trials and in the planning of malaria control measures.

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Open Access | Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda

July 13, 2010 - 14:54 -- Kabogo Ndegwa
Author(s): 
Kyabayinze DJ, Asiimwe C, Nakanjako D, Nabakooza J, Counihan H, Tibenderana JK
Reference: 
Malaria Journal 2010, 9:200 (12 July 2010)

Use of RDTs resulted in a 2-fold reduction in anti-malarial drug prescription at LLHCFs. The study demonstrated that RDT use is feasible at LLHCFs, and can lead to better targetting of malaria treatment.

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