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Scientific Articles

Open Access | Cost Implications of Improving Malaria Diagnosis: Findings from North-Eastern Tanzania

January 29, 2010 - 10:55 -- Ingeborg van Schayk
Author(s): 
Jacklin F. Mosha, Lesong Conteh, Fabrizio Tediosi, Samwel Gesase, Jane Bruce, Daniel Chandramohan, Roly Gosling
Reference: 
PLoS ONE 5(1): e8707

This paper attempts to estimate the rates of over diagnosis of malaria among children attending dispensaries in rural Tanzania and examines the potential cost implications of improving the quality of diagnosis.

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Update: Only the good die young: a novel paradigm for mosquito control

January 28, 2010 - 12:52 -- Kabogo Ndegwa
Author(s): 
Peter F. Billingsley
Reference: 
Trends in Parasitology, Volume 26, Issue 2, February 2010, Pages 53-55

Andrew Read and colleagues have proposed that insecticides acting late in the vector lifetime are less susceptible to evolutionary pressures, thereby avoiding insecticide resistance.

Heat shock proteins contribute to mosquito dehydration tolerance

January 28, 2010 - 12:50 -- Kabogo Ndegwa
Author(s): 
Joshua B. Benoit, Giancarlo Lopez-Martinez, Zachary P. Phillips, Kevin R. Patrick and David L. Denlinger
Reference: 
Journal of Insect Physiology, Volume 56, Issue 2, February 2010, Pages 151-156

This study examines the responses of heat shock protein transcripts, Hsp70 and Hsp90, to dehydration stress in three mosquito species, Aedes aegypti, Anopheles gambiae and Culex pipiens. 

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Review: Do paediatric drug formulations of artemisinin combination therapies improve the treatment of children with A systematic review and meta-analysis

January 28, 2010 - 12:47 -- Kabogo Ndegwa
Author(s): 
Florian Kurth, Sabine Bélard, Ayola A Adegnika, Prof Oumar Gaye, Prof Peter G Kremsner, and Dr Michael Ramharter
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 2, February 2010, Pages 125-132

These data provide, for the first time, evidence for improved management of children by use of paediatric formulations, and support the further development and use of paediatric ACTs.

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The role of platelets in the pathogenesis of cerebral malaria

January 28, 2010 - 12:40 -- Kabogo Ndegwa
Author(s): 
Dermot Cox and Sam McConkey
Reference: 
Cellular and Molecular Life Sciences, Volume 67, Number 4 / February, 2010, Pages 557-568

There is a strong association between thrombocytopenia and outcome in malaria, suggesting a role for platelets in the pathogenesis of malaria.

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Report: “Singing on the Wing” as a Mechanism for Species Recognition in the Malarial Mosquito Anopheles gambiae

January 28, 2010 - 12:38 -- Kabogo Ndegwa
Author(s): 
Cédric Pennetier, Ben Warren, K. Roch Dabiré, Ian J. Russell, and Gabriella Gibson
Reference: 
Current Biology, Volume 20, Issue 2, 26 January 2010, Pages 131-136

This is the first description of close-range mating interactions in incipient An. gambiae species.

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Dispatch: Speciation: Mosquitoes Singing in Harmony

January 28, 2010 - 12:37 -- Kabogo Ndegwa
Author(s): 
Michael G. Ritchiea, and Elina Immonen
Reference: 
Current Biology, Volume 20, Issue 2, 26 January 2010, Pages R58-R60

Anopheles gambiae, a major vector of malaria, is a complex of cryptic species and subspecies. A new study describes a remarkable behaviour that might contribute to sexual isolation in this species complex: males and females are much more likely to show harmonic convergence of wing beat sounds when courting individuals of the same type.

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Genetics and Evolution: Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population

January 28, 2010 - 12:35 -- Kabogo Ndegwa
Author(s): 
S. Knowles, V. Palinauskas, B. Sheldon
Reference: 
Journal of Evolutionary Biology, Volume 23 Issue 3, Pages 557 – 569

Overall, these results demonstrate that chronic avian malaria infections, far from being benign, can have significant effects on host fitness and may thus constitute an important selection pressure in wild bird populations.

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Computational characterization of Plasmodium falciparum proteomic data for screening of potential vaccine candidates

January 28, 2010 - 12:34 -- Kabogo Ndegwa
Author(s): 
Satarudra P. Singh, Feroz Khan and Bhartendu N. Mishra
Reference: 
Human Immunology, Volume 71, Issue 2, February 2010, Pages 136-143

In this study, we have characterized 25 antigens as a vaccine candidate and screened the potential T-lymphocyte epitopes presented by human leukocyte antigen (HLA)-A, -B, and -DR molecules based on the proteomic data of Plasmodium falciparum.

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