The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10240 malaria professionals are enjoying the free benefits of MalariaWorld today

Scientific Articles

Opinion: The murine cerebral malaria phenomenon

December 29, 2009 - 14:05 -- Patrick Sampao
Author(s): 
Nicholas J. White, Gareth D.H. Turner, Isabelle M. Medana, Arjen M. Dondorp, and Nicholas P.J. Day
Reference: 
Trends in Parasitology, Volume 26, Issue 1, January 2010, Pages 11-15

P.berghei ANKA infection in CBA or CB57BL/6 mice is used widely as a murine ‘model’ of human cerebral malaria (HCM), despite markedly different histopathological features.

Medical Condition: 

Review: Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

December 29, 2009 - 13:52 -- Patrick Sampao
Author(s): 
Prof Stephen J Rogerson FRACP, Rushika S Wijesinghe MD, and Steven R Meshnick MD
Reference: 
The Lancet Infectious Diseases, Volume 10, Issue 1, January 2010, Pages 51-59

Improved methods for assessing antimalarial immunity will strengthen malaria control efforts.

Medical Treatment: 

Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: Effects against nociception, inflammation, and pyrexia in rats and mice

December 29, 2009 - 13:28 -- Patrick Sampao
Author(s): 
J. Abbah, S. Amos, B. Chindo, I. Ngazal, H.O. Vongtau, B. Adzu, T. Farida, A.A. Odutola, C. Wambebe and K.S. Gamaniel
Reference: 
Journal of Ethnopharmacology, Volume 127, Issue 1, 8 January 2010, Pages 85-90

The results suggest the presence of biologically active principles in the extract with anti-nociceptive, anti-inflammatory and anti-pyretic activities that justifies its use in malaria ethnopharmacy and subsequent development for clinical application.

Medical Condition: 

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

December 29, 2009 - 13:12 -- Patrick Sampao
Author(s): 
Qin Liu, Zongxiang Tang, Lenka Surdenikova, Seungil Kim, Kush N. Patel, Andrew Kim, Fei Ru, Yun Guan, Hao-Jui Weng, Yixun Geng, Bradley J. Undem, Marian Kollarik, Zhou-Feng Chen, David J. Anderson, and Xinzhong Dong
Reference: 
Cell, Volume 139, Issue 7, 24 December 2009, Pages 1353-1365

Itch induced by chloroquine (CQ) is a common side effect of this widely used antimalarial drug. Here, we show that Mrgprs, a family of G protein-coupled receptors expressed exclusively in peripheral sensory neurons, function as itch receptors.

Medical Condition: 
Medical Treatment: 

A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium

December 29, 2009 - 13:08 -- Patrick Sampao
Author(s): 
Luciano A. Moreira, Iñaki Iturbe-Ormaetxe, Jason A. Jeffery, Guangjin Lu, Alyssa T. Pyke, Lauren M. Hedges, Bruno C. Rocha, Sonja Hall-Mendelin, Andrew Day, Markus Riegler, Leon E. Hugo, Karyn N. Johnson, Brian H. Kay, Elizabeth A. McGraw, Andrew F. van den Hurk, Peter A. Ryan and Scott L. O'Neill
Reference: 
Cell, Volume 139, Issue 7, 24 December 2009, Pages 1268-1278

We suggest that this Wolbachia-mediated pathogen interference may work synergistically with the life-shortening strategy proposed previously to provide a powerful approach for the control of insect transmitted diseases.

Medical Condition: 

Correspondence: Severe Malaria Studies: Challenge to Balance Clinical Medicine and Public Health

December 29, 2009 - 13:00 -- Patrick Sampao
Author(s): 
G. Dennis Shanks
Reference: 
Clinical Infectious Diseases, 15 January 2010; Vol 50:282–283

No abstract available

Medical Condition: 
Medical Treatment: 

Correspondence: Studies on Severe Malaria Are Still Possible and Essential

December 29, 2009 - 12:52 -- Patrick Sampao
Author(s): 
Richard J. Maude, Mahtab Uddin Hassan,Aniruddha Ghose, Samuel T. Douthwaite,M. Abul Faiz, and Arjen M. Dondorp
Reference: 
Clinical Infectious Diseases, 15 January 2010; Vol 50:281–282

No abstract available

Technology: 
Medical Condition: 

Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria

December 29, 2009 - 12:39 -- Patrick Sampao
Author(s): 
Anne-Marit Sponaas, Ana Paula Freitas do Rosario, Cecile Voisine, Beatris Mastelic, Joanne Thompson, Sandra Koernig, William Jarra, Laurent Renia, Marjorie Mauduit, Alexandre J. Potocnik, and Jean Langhorne
Reference: 
Blood, 24 December 2009, Vol. 114, No. 27, pp. 5522-5531.

During Plasmodium chabaudi infection in mice, a population of CD11bhighLy6C+ monocytes are generated in bone marrow, most of which depend on the chemokine receptor CCR2 for migration from bone marrow to the spleen.

Medical Condition: 

Open Access | Plasmodium falciparum var gene expression is modified by host immunity

December 24, 2009 - 14:25 -- Ingeborg van Schayk
Author(s): 
George M. Warimwe, Thomas M. Keane, Gregory Fegan, Jennifer N. Musyoki, Charles R. J. C. Newton, Arnab Pain, Matthew Berriman, Kevin Marsh, and Peter C. Bull
Reference: 
PNAS December 22, 2009 vol. 106 no. 51 21801-21806

Here, in a study of 217 Kenyan children with malaria, we show that expression of a group of var genes “cys2,” containing a distinct pattern of cysteine residues, is associated with low host immunity.

Pages

Subscribe to Scientific Articles