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Scientific Articles

Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

October 25, 2009 - 16:33 -- Bart G.J. Knols
Author(s): 
Stephen L. Hoffman et al.
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

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Alternative approaches to vaccine delivery

October 25, 2009 - 16:31 -- Ingeborg van Schayk
Author(s): 
Lina Wang, Charles Ma and Ross L. Coppel
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Subunit vaccines under development for malaria utilise a limited number of approaches to delivery. 

Therefore, along with the efforts to advance the most promising vaccine formulations through the development pipeline, research is taking place into alternative methods for cheaper vaccine production and easy administration. This chapter will discuss some of these approaches, including transgenic plants and mammals as bioreactors for low cost vaccine production and alternative routes of vaccine delivery such as mucosal immunization.

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Whole parasite blood stage malaria vaccines: A convergence of evidence

October 25, 2009 - 16:29 -- Bart G.J. Knols
Author(s): 
James S McCarthy and Michael F. Good
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

In this review previous studies in rodents and primates of whole killed and attenuated blood stage vaccines, and recent work on the effect of genetically attenuated parasites on immunity in rodent models of blood stage immunity are discussed. The relationship between these findings and what is now known about protective immunity in human populations, specifically against the blood stages of the parasite lifecycle is discussed and recent findings from human experimental infection are be reviewed.

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Prime-boost vectored malaria vaccines: Progress and prospects

October 25, 2009 - 16:25 -- Ingeborg van Schayk
Author(s): 
Adrian V. S. Hill, Arturo Reyes-Sandoval, Geraldine O’Hara, Katie Ewer, Alison Lawrie, Anna Goodman, Alfredo Nicosia, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Sarah C. Gilbert and Simon Draper
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

The difficulty of inducing protective immunity through antibodies against sporozoites led to efforts to assess vectored vaccines as a means of inducing protective T cell immunity against the malaria liver-stage parasite. Although DNA vectored vaccines used alone were poorly immunogenic and not protective, high levels of parasite clearance in the liver has been achieved with viral vectored vaccines used in heterologous prime-boost regimes.

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Vaccines against malaria: Perspectives from Papua New Guinea

October 25, 2009 - 16:21 -- Bart G.J. Knols
Author(s): 
Ivo Mueller, Blaise Genton, Inoni Betuela and Michael P. Alpers
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Despite its small population and isolate location Papua New Guinea (PNG) with a malaria burden comparable to sub-Saharan Africa, its intense transmission of all 4 human Plasmodium species and an unrivalled combination of environmental and human variation offers unique perspectives on malaria vaccines.

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Guidelines and considerations for testing malaria vaccines in pregnant women

October 25, 2009 - 16:20 -- Ingeborg van Schayk
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Author(s): 
Clara Menendez and Pedro Alonso
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Important progress has been made in the last years especially in sub-Saharan Africa, with the introduction of strategies to prevent malaria in pregnancy consisting of intermittent preventive treatment and insecticide treated nets. However, their coverage is still unacceptably low and malaria continues to demand a huge toll on pregnant women and their newborns. Thus, there is a need to explore other preventive strategies such as a vaccine against malaria, which combined with the current tools would maximise the protection efficacy.

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Special Focus Review: European malaria vaccine initiative: Portfolio and perspectives for the future

October 25, 2009 - 16:12 -- Ingeborg van Schayk
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Author(s): 
Egeruan Babatunde Imoukhuede, Roland Ventura, Nathalie Imbault, Harry van Schooten and Odile Leroy
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

Over the past ten years, EMVI has continually strived to maintain its main goal of accelerating the development of candidate malaria vaccines by facilitating the translational gap between promising experimental malaria vaccines and subsequent clinical trials in Europe and in Africa. By stimulating collaboration, cooperation, networking and joint integrated activities across various fields of research and diseases, and by facilitating the federation of research infrastructures, EMVI is acting today as a catalyst for tomorrow’s vaccines.

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Special Focus Review: The role of Plasmodium falciparum variant surface antigens in protective immunity and vaccine development

October 25, 2009 - 16:06 -- Ingeborg van Schayk
Author(s): 
Lars Hviid
Reference: 
Human Vaccines, Volume 6, Issue 1, January 2010

This review summarizes the evidence that VSAs are important targets of NAI, discusses why VSA-based vaccines might be feasible despite the extensive intra- and interclonal variation of VSAs, and how vaccines based on this type of antigens fit into the current global strategy to reduce, eliminate, and eventually eradicate the burden of malaria.

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Heritability of Antibody Isotype and Subclass Responses to Plasmodium falciparum Antigens

October 25, 2009 - 16:06 -- Bart G.J. Knols
Author(s): 
Tetteh KKA, Whittle HC, et al.
Reference: 
PLoS ONE 4(10): e7381. doi:10.1371/journal.pone.0007381

Genome-wide approaches are now warranted to map the major genetic determinants of variable antibody isotype and subclass responses to malaria, alongside evaluation of their impact on infection and disease. Although plasma levels of IgG4 to malaria antigens are generally low, the exceptionally high heritability of levels of this subclass in children deserves particular investigation.

 

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Absence of Erythrocyte Sequestration and Lack of Multicopy Gene Family Expression in Plasmodium falciparum from a Splenectomized Malaria Patient

October 25, 2009 - 16:01 -- Bart G.J. Knols
Author(s): 
Predehl S, von Kalckreuth V, et al.
Reference: 
PLoS ONE 4(10): e7459. doi:10.1371/journal.pone.0007459

This case strongly supports the hypothesis that parasite surface proteins such as PfEMP1, A-type RIFIN or STEVOR are involved in interactions of infected erythrocytes with endothelial receptors mediating sequestration of mature asexual and immature sexual stages of P. falciparum. In contrast, multicopy gene families coding for B-type RIFIN and PfMC-2TM proteins may not be involved in sequestration, as these genes were transcribed in infected but not sequestered erythrocytes.

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